2022
DOI: 10.1007/s10856-021-06570-2
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A comprehensive review on methods for promotion of mechanical features and biodegradation rate in amniotic membrane scaffolds

Abstract: Amniotic membrane (AM) is a biological tissue that surrounds the fetus in the mother’s womb. It has pluripotent cells, immune modulators, collagen, cytokines with anti-fibrotic and anti-inflammatory effect, matrix proteins, and growth factors. In spite of the biological characteristics, some results have been released in preventing the adhesion on traumatized surfaces. Application of the AM as a scaffold is limited due to its low biomechanical resistance and rapid biodegradation. Therefore, for using the AM du… Show more

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Cited by 12 publications
(16 citation statements)
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“…However, up to the present time, the other potential usage of lenticule scaffolds such as drug delivery and incorporation with growth factors or nanoparticles have been rarely studied [44]. Because of the advantage of not causing damage to the fiber structure and having no toxic effects on cell activity, EDC is widely used to enhance the biomechanical strength and optical properties of materials such as collagen hydrogels [45] or amniotic membranes [46].…”
Section: Discussionmentioning
confidence: 99%
“…However, up to the present time, the other potential usage of lenticule scaffolds such as drug delivery and incorporation with growth factors or nanoparticles have been rarely studied [44]. Because of the advantage of not causing damage to the fiber structure and having no toxic effects on cell activity, EDC is widely used to enhance the biomechanical strength and optical properties of materials such as collagen hydrogels [45] or amniotic membranes [46].…”
Section: Discussionmentioning
confidence: 99%
“…Hence, to be applied clinically, modification of AM structures was suggested to increase its tensile strength which may prolong its degradation rate. Some methods were suggested, for instance, by cross-linking AM with composite materials, physical cross-linking, and chemical cross-linking with glutaraldehyde, carbodiimide, genipin, and aluminum sulfate [ 9 , 28 ]. An animal study by Zhang et al used fresh AM treated with ultraviolet cross-linking for conjunctival transplantation on rabbits and compared it with control AM [ 29 ].…”
Section: Discussionmentioning
confidence: 99%
“…It was also noted that the glutaraldehyde-treated AM was virtually completely resistant to the enzymatic digestion test, while fresh and cryopreserved AM were dissolved completely by day seven. This suggests that collagen cross-linking using glutaraldehyde leads to a significant increase in the biomechanical strength and enzymatic resistance of AM, which can be employed to prolong the degradation time of AM in the oral cavity [ 9 , 29 ]. Thus, it can be proposed that the placement of AM as a barrier membrane prevents the early exposure of the surgical site to produce the desired effects [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
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“…As mentioned above, dHAM has low mechanical properties and biodegradation, making it easily ruptured during use on wounds and handling during surgical procedures [23]. Furthermore, the inherent properties of intact AM, such as thickness, transparency, and tensile strength, can vary signifcantly among donors [42]. Tis variability poses challenges in standardizing its use for consistent and predictable outcomes in tissue engineering.…”
Section: Introductionmentioning
confidence: 99%