A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics

Gao, Jingxia; Yang, Zhe; Zhao, Chongqi; Tang, Xiongzhuo; Jiang, Qian; Yin, Yan

doi:10.1007/s11427-022-2246-4

Cited by 32 publications

(19 citation statements)

References 132 publications

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“…Thus, phenolic compounds are found in abundance in vegetables, fruits, and cereals [ 39 ]. The high consumption of foods rich in phenolic compounds can prevent a series of diseases [ 40 ].…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil

Kauffmann

Castro

2023

Antibiotics

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Phenolic compounds are natural substances that are produced through the secondary metabolism of plants, fungi, and bacteria, in addition to being produced by chemical synthesis. These compounds have anti-inflammatory, antioxidant, and antimicrobial properties, among others. In this way, Brazil represents one of the most promising countries regarding phenolic compounds since it has a heterogeneous flora, with the presence of six distinct biomes (Cerrado, Amazon, Atlantic Forest, Caatinga, Pantanal, and Pampa). Recently, several studies have pointed to an era of antimicrobial resistance due to the unrestricted and large-scale use of antibiotics, which led to the emergence of some survival mechanisms of bacteria to these compounds. Therefore, the use of natural substances with antimicrobial action can help combat these resistant pathogens and represent a natural alternative that may be useful in animal nutrition for direct application in food and can be used in human nutrition to promote health. Therefore, this study aimed to (i) evaluate the phenolic compounds with antimicrobial properties isolated from plants present in Brazil, (ii) discuss the compounds across different classes (flavonoids, xanthones, coumarins, phenolic acids, and others), and (iii) address the structure–activity relationship of phenolic compounds that lead to antimicrobial action.

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Section: Phenolic Compoundsmentioning

confidence: 99%

Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil

Kauffmann

Castro

2023

Antibiotics

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“…Plant‐derived phenolic compounds encompass a diverse group, including flavonoids, ligands, tannins, xanthines and coumarins 266,267 . These compounds are renowned for their anticancer activity and their ability to combat diseases associated with oxidative stress 268–270 . Among the known polyphenols in nature, gallic acid stands out 271–273 .…”

Section: Natural Compounds Targeting Ferroptosis In Breast Cancermentioning

confidence: 99%

“… 266 , 267 These compounds are renowned for their anticancer activity and their ability to combat diseases associated with oxidative stress. 268 , 269 , 270 Among the known polyphenols in nature, gallic acid stands out. 271 , 272 , 273 Also known as 3,4,5‐trihydroxybenzoic acid, gallic acid boasts important anticancer properties with antioxidant effects.…”

Section: Natural Compounds Targeting Ferroptosis In Breast Cancermentioning

confidence: 99%

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

Ge,

He,

Zhao

et al. 2023

J Cellular Molecular Medi

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Breast cancer is the most prevalent cancer worldwide and its incidence increases with age, posing a significant threat to women's health globally. Due to the clinical heterogeneity of breast cancer, the majority of patients develop drug resistance and metastasis following treatment. Ferroptosis, a form of programmed cell death dependent on iron, is characterized by the accumulation of lipid peroxides, elevated levels of iron ions and lipid peroxidation. The underlying mechanisms and signalling pathways associated with ferroptosis are intricate and interconnected, involving various proteins and enzymes such as the cystine/glutamate antiporter, glutathione peroxidase 4, ferroptosis inhibitor 1 and dihydroorotate dehydrogenase. Consequently, emerging research suggests that ferroptosis may offer a novel target for breast cancer treatment; however, the mechanisms of ferroptosis in breast cancer urgently require resolution. Additionally, certain natural compounds have been reported to induce ferroptosis, thereby interfering with breast cancer. Therefore, this review not only discusses the molecular mechanisms of multiple signalling pathways that mediate ferroptosis in breast cancer (including metastasis, invasion and proliferation) but also elaborates on the mechanisms by which natural compounds induce ferroptosis in breast cancer. Furthermore, this review summarizes potential compound types that may serve as ferroptosis inducers in future tumour cells, providing lead compounds for the development of ferroptosis‐inducing agents. Last, this review proposes the potential synergy of combining natural compounds with traditional breast cancer drugs in the treatment of breast cancer, thereby suggesting future directions and offering new insights.

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“…Drugs that target MSTN have emerged as a promising therapeutic approach for the treatment of muscle atrophy. − However, no pharmaceuticals targeting this protein have been introduced into clinical practice. Natural compounds derived from food sources represent a treasure trove of nature; they contain numerous small molecules with unknown effects that hold great potential for pharmaceutical development. − While traditional screening methods are time-consuming and labor-intensive when it comes to screening a vast number of compounds, computer-aided drug design (CADD) can significantly shorten the time and process of drug screening. Moreover, utilizing computer simulations for molecular docking enables proactive assessment of the interactions between drugs and targets, facilitating a deeper understanding of the mechanisms of action. , This endeavor provides a solid foundation for drug research and application.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Potential of Nelumbo nucifera-Derived Liensinine to Target The Myostatin Protein and to Counteract Muscle Atrophy

Zheng,

Yu,

Feng

et al. 2024

J. Agric. Food Chem.

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Muscle atrophy refers to a decline in muscle mass and function, which has become a global concern due to the aging population. Various clinical trials have investigated the inhibitors of myostatin (MSTN). They have shown promising improvements in muscle function and quality of life. However, there are no drugs specifically targeting MSTN that have been approved for clinical use. In this study, we virtually screened liensinine (LIE), a food (Nelumbo nucifera)-derived compound, with low toxicity, from over 1.1 million compounds. We subsequently identified it as a potential candidate that targets MSTN by a cellular thermal shift assay (CETSA) and drug affinity response target stability (DARTS) assay. Further validation through cellular and in vivo studies demonstrated its promising potential in combating muscle atrophy. The mechanism of action may involve hindering the interaction between MSTN and the activin receptor type IIB (ActRIIB) and downregulating the expression of downstream proteins, including the muscle RING-finger protein-1 (MuRF-1) and muscle atrophy F-box (MAFbx)/Atrogin-1, ultimately promoting muscle regeneration. These results provide a strong foundation for future studies to explore the therapeutic potential of LIE in clinical settings.

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A comprehensive review on natural phenolic compounds as alternatives to in-feed antibiotics

Cited by 32 publications

References 132 publications

Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil

Phenolic Compounds in Bacterial Inactivation: A Perspective from Brazil

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

Unveiling the Potential of Nelumbo nucifera-Derived Liensinine to Target The Myostatin Protein and to Counteract Muscle Atrophy

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