A comprehensive review on pharmaceutical uses of plant-derived biopolysaccharides

Guru, Pravat Ranjan; Kar, Rajat Kumar; Nayak, Amit Kumar; Mohapatra, Snehamayee

doi:10.1016/j.ijbiomac.2023.123454

Cited by 20 publications

(8 citation statements)

References 132 publications

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“…Astragalus polysaccharide process complex biological activities including anti-inflammation, antioxidant, antiviral, anticancer, and immune functions ( 16 , 24–27 ) and are applied as an additive with non-toxic side effects, low cost, and no residue. Indeed, polysaccharides are macromolecules with the chemical structures (primary, secondary, tertiary, and quaternary structures) which contribute to its biological activities ( 28 , 29 ). Nevertheless, polysaccharide structural analysis indicated that polysaccharide structures are very complex and comprehensive structures were characterized by monosaccharide composition, Fourier transform infrared and nuclear magnetic resonance spectroscopy (NMR) analysis ( 29 , 30 ).…”

Section: Characteristics Of Astragalus Polysaccharidementioning

confidence: 99%

Astragalus polysaccharide: implication for intestinal barrier, anti-inflammation, and animal production

Liang,

Tao,

Wang

et al. 2024

Front. Nutr.

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Intestine is responsible for nutrients absorption and plays a key role in defending against various dietary allergens, antigens, toxins, and pathogens. Accumulating evidence reported a critical role of intestine in maintaining animal and human health. Since the use of antibiotics as growth promoters in animal feed has been restricted in many countries, alternatives to antibiotics have been globally investigated, and polysaccharides are considered as environmentally friendly and promising alternatives to improve intestinal health, which has become a research hotspot due to its antibiotic substitution effect. Astragalus polysaccharide (APS), a biological macromolecule, is extracted from astragalus and has been reported to exhibit complex biological activities involved in intestinal barrier integrity maintenance, intestinal microbiota regulation, short-chain fatty acids (SCFAs) production, and immune response regulation, which are critical for intestine health. The biological activity of APS is related to its chemical structure. In this review, we outlined the source and structure of APS, highlighted recent findings on the regulation of APS on physical barrier, biochemical barrier, immunological barrier, and immune response as well as the latest progress of APS as an antibiotic substitute in animal production. We hope this review could provide scientific basis and new insights for the application of APS in nutrition, clinical medicine and health by understanding particular effects of APS on intestine health, anti-inflammation, and animal production.

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Section: Characteristics Of Astragalus Polysaccharidementioning

confidence: 99%

Astragalus polysaccharide: implication for intestinal barrier, anti-inflammation, and animal production

Liang,

Tao,

Wang

et al. 2024

Front. Nutr.

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“…Its main application is in the food industry, pharmaceuticals and cosmetics. Recently, gum arabic has been extensively used for drug delivery and in a biomedical domain, as nanoscaffolds [92][93][94][95].…”

Section: Gumsmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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Biomaterials are mostly any natural and synthetic materials which are compatible from a biological point of view with the human body. Biomaterials are widely used to sustain, increase, reestablish or substitute the biological function of any injured tissue and organ from the human body. Additionally, biomaterials are uninterruptedly in contact with the human body, i.e., tissue, blood and biological fluids. For this reason, an essential feature of biomaterials is their biocompatibility. Consequently, this review summarizes the classification of different types of biomaterials based on their origin, as natural and synthetic ones. Moreover, the advanced applications in pharmaceutical and medical domains are highlighted based on the specific mechanical and physical properties of biomaterials, concerning their use. The high-priority challenges in the field of biomaterials are also discussed, especially those regarding the transfer and implementation of valuable scientific results in medical practice.

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“…Polysaccharides from basil are mainly present in seeds and have shown antibacterial, anti-inflammatory, and immunostimulant properties [30]. Moreover, basil seed mucilage has been used to formulate hydrogel films for wound dressing drug delivery [31].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides and Phenolic Compounds Recovered from Red Bell Pepper, Tomato and Basil By-Products Using a Green Extraction by Extractor Timatic®

Khatib,

Cecchi,

Bellumori

et al. 2023

IJMS

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Fruits and vegetables processing produces significant amounts of by-products rich in valuable bioactive compounds such as polyphenols and dietary fiber. Food by-product re-use promotes the eco-sustainability of several crops. This study aimed to apply green extractions of bioactive compounds from by-products of basil, tomato, and red bell pepper production. Tests were performed by applying extraction procedures both at laboratory scale and using the Timatic® extractor. Water and ethanol 10% and 20% were used for extraction of red bell pepper and tomato, testing different temperatures (30, 50, and 90 °C; water at 90 °C and ethanol 20% were applied for basil. The obtained phenolic extracts were analyzed by HPLC-DAD-MS. Polysaccharides of tomato and red bell pepper were extracted at laboratory scale and chemically characterized using 1H-NMR to define the methylation and acylation degree, and DLS to estimate the hydrodynamic volume. Laboratory extraction tests allowed efficient scaling-up of the process on the Timatic® extractor. Phenolic content in the dried extracts (DE) ranged 8.0–11.2 mg/g for tomato and red bell pepper and reached 240 mg/g for basil extracts. Polysaccharide yields (w/w on DM) reached 6.0 and 10.4% for dried tomato and red bell pepper, respectively. Dry extracts obtained using the Timatic® extractor and water can be useful sources of bioactive phenols. The study provided new data on tomato and red bell pepper polysaccharides that may be useful for future applications.

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A comprehensive review on pharmaceutical uses of plant-derived biopolysaccharides

Cited by 20 publications

References 132 publications

Astragalus polysaccharide: implication for intestinal barrier, anti-inflammation, and animal production

Astragalus polysaccharide: implication for intestinal barrier, anti-inflammation, and animal production

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Polysaccharides and Phenolic Compounds Recovered from Red Bell Pepper, Tomato and Basil By-Products Using a Green Extraction by Extractor Timatic®

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