2021
DOI: 10.22159/ijap.2021v13i3.40863
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A Comprehensive Review on Pharmaceutical and Nutritional Applications of Inulin

Abstract: Inulin is a versatile, water-soluble polysaccharide that is commonly available in nature. In the pharmaceutical industry, the non-digestible function of inulin has made it attractive. Inulin is granted with GRAS status by the FDA and more than 30,000 plants in nature store inulin as a carbohydrate. The chicory is the key plant source of inulin out of all sources. It can be used as the sugar or fat replacer in the processed foods to influence the desirable characteristics. Good biocompatibility, essential chemi… Show more

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Cited by 6 publications
(3 citation statements)
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“…Colon-specific drug delivery has long been used to enhance therapeutic effectiveness by reducing unwanted absorption in other regions of the gastrointestinal tract, guaranteeing that the whole drug dose is specifically delivered to the site of interest in the colon [6,7]. Most colon-targeted drug delivery systems are either responsive to the pH of the colon or to enzymes produced by intestinal microbiota [8][9][10]. For instance, metronidazole, which is used for treatment of bowel infection, was formulated in a tablet containing pH-sensitive polymers consisting of Eudragit E, Eudragit L, and alginate in order to delay the release of metronidazole and achieve a once daily formulation [11].…”
Section: Introductionmentioning
confidence: 99%
“…Colon-specific drug delivery has long been used to enhance therapeutic effectiveness by reducing unwanted absorption in other regions of the gastrointestinal tract, guaranteeing that the whole drug dose is specifically delivered to the site of interest in the colon [6,7]. Most colon-targeted drug delivery systems are either responsive to the pH of the colon or to enzymes produced by intestinal microbiota [8][9][10]. For instance, metronidazole, which is used for treatment of bowel infection, was formulated in a tablet containing pH-sensitive polymers consisting of Eudragit E, Eudragit L, and alginate in order to delay the release of metronidazole and achieve a once daily formulation [11].…”
Section: Introductionmentioning
confidence: 99%
“…10,11 Moreover, inulin has received a generally recognized as safe status (GRAS) by FDA due to its outstanding properties such as biodegradability, non-toxicity, renewability compared to other polysaccharides. 11,12 It is a suitable material to deliver drugs safely to colon where they can be easily absorbed through the gut epithelium into the blood. 10 Therefore, in the last few years, attention has been paid on inulin-based nanostructures for drug delivery applications.…”
Section: Introductionmentioning
confidence: 99%
“…Being a multifunctional polysaccharide, it is being employed as a dietary fiber with extensive health benefits and can also be used in other biomedical applications 10,11 . Moreover, inulin has received a generally recognized as safe status (GRAS) by FDA due to its outstanding properties such as biodegradability, non‐toxicity, renewability compared to other polysaccharides 11,12 . It is a suitable material to deliver drugs safely to colon where they can be easily absorbed through the gut epithelium into the blood 10 .…”
Section: Introductionmentioning
confidence: 99%