A Comprehensive review on Pharmacokinetic Studies of Vaccines: Impact of delivery route, carrier-and its modulation on immune response

Jha, Saurav Kumar; Imran, Mohammad; Jha, Laxmi Akhileshwar; Hasan, Nazeer; Panthi, Vijay Kumar; Paudel, Keshav Raj; Almalki, Waleed H.; Mohammed, Yousuf; Kesharwani, Prashant

doi:10.1016/j.envres.2023.116823

Cited by 9 publications

(1 citation statement)

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“…There might be some other attributes of the human skin which also affects the delivery and overall chemotherapeutic efficacy. The pharmacodynamic effects such nanovechicles is also dependent on the route of delivery (topical/intravenous/intratumoral/subcutaneous) [361]. To achieve the desired pharmacological effectiveness, the nanovehicle should carry a drug and absorbed at the site of administration such as skin.…”

Section: Nanotechnological Approaches To Tackle Skin Cancer (Critical...mentioning

confidence: 99%

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Hasan,

Nadaf,

Imran

et al. 2023

Mol Cancer

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Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge. To bridge the gap and bring effective treatment, it is important to understand the etiology of skin carcinoma, the mechanism of cell proliferation, factors affecting cell growth, and the mechanism of drug resistance. The current article focusses on understanding the structural diversity of skin cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination therapy, molecular targets associated with cancer growth and metastasis, and special emphasis on nanotechnology-based approaches for downregulating the deleterious disease. A detailed analysis with respect to types of nanoparticles and their scope in overcoming multidrug resistance as well as associated clinical trials has been discussed. Graphical Abstract

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Section: Nanotechnological Approaches To Tackle Skin Cancer (Critical...mentioning

confidence: 99%