A comprehensive review on silver nanoparticles: Synthesis approaches, characterization techniques, and recent pharmaceutical, environmental, and antimicrobial applications

Magdy, Galal; Aboelkassim, Eman; Abd Elhaleem, Shymaa M.; Belal, Fathalla

doi:10.1016/j.microc.2023.109615

Cited by 28 publications

(2 citation statements)

References 195 publications

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“…The bottom-up methods are performed using reducing and capping agents, which can be either chemical or natural (green). 8,9 The prevalent approach for synthesizing AgNPs involves chemical reduction, achieved by reducing a silver precursor with substances like sodium borohydride and N,N-dimethylformamide. 10,11 However, the use of green methods in AgNP synthesis has witnessed a signicant upsurge due to their inherent advantages, such as accessibility, cost-effectiveness, energy efficiency, environmental friendliness, and low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Biogenic silver nanoparticles' antibacterial activity and cytotoxicity on human hepatocarcinoma cells (Huh-7)

Santana da Costa,

Rodrigues da Silva,

Jerônimo Barbosa

et al. 2024

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Biogenic silver nanoparticles' antibacterial activity and cytotoxicity on human hepatocarcinoma cells (Huh-7)

Santana da Costa,

Rodrigues da Silva,

Jerônimo Barbosa

et al. 2024

RSC Adv.

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“…[17][18][19][20] Many studies have aimed at developing novel nanomaterial-based sensors for applications in biology and medicine, while their clinical applications are greatly restricted by high cost and adding highly toxic components. [21][22][23] As novel nanomaterials, carbon dots (CDs) have gained particular attention in recent years owing to their outstanding characteristics and wide-ranging pharmaceutical applications. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] In particular, their small size and large surface area make them highly water-soluble and biocompatible, which holds great promise for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Novel Carbon Dots Derived from Moutan Cortex Significantly Improve the Solubility and Bioavailability of Mangiferin

Kong,

Wang,

Sun

et al. 2024

IJN

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Background Mangiferin (MA), a bioactive C-glucosyl xanthone with a wide range of interesting therapeutic properties, has recently attracted considerable attention. However, its application in biomedicine is limited by poor solubility and bioavailability. Carbon dots (CDs), novel nanomaterials, have immense promise as carriers for improving the biopharmaceutical properties of active components because of their outstanding characteristics. Methods In this study, a novel water-soluble carbon dot (MC-CDs) was prepared for the first time from an aqueous extract of Moutan Cortex Carbonisata , and characterized by various spectroscopies, zeta potential and high-resolution transmission electron microscopy (HRTEM). The toxicity effect was investigated using the CCK-8 assay in vitro. In addition, the potential of MC-CDs as carriers for improving the pharmacokinetic parameters was evaluated in vivo. Results The results indicated that MC-CDs with a uniform spherical particle size of 1–5 nm were successfully prepared, which significantly increased the solubility of MA in water. The MC-CDs exhibited low toxicity in HT-22 cells. Most importantly, the MC-CDs effectively affected the pharmacokinetic parameters of MA in normal rats. UPLC-MS analysis indicated that the area under the maximum blood concentration of MA from mangiferin-MC-CDs (MA-MC-CDs) was 1.6-fold higher than that from the MA suspension liquid (MA control) after oral administration at a dose of 20 mg/kg. Conclusion Moutan Cortex -derived novel CDs exhibited superior performance in improving the solubility and bioavailability of MA. This study not only opens new possibilities for the future clinical application of MA but also provides evidence for the development of green biological carbon dots as a drug delivery system to improve the biopharmaceutical properties of insoluble drugs.

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In‐Situ and Green Synthesis of Silk Fibroin‐Silver Nanoparticles Composite Microfibers for Enhanced Antibacterial Applications

Zhang,

Luo,

Jaber

et al. 2024

ChemPlusChem

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The antibacterial properties of modified silk fibroin microfibers (SF MFs) have been widely studied. Among various modifications, integration of silver nanoparticles (Ag NPs) and SF MFs has garnered significant attention due to the broad‐spectrum antibacterial activities and long‐term antibacterial effect of Ag nanomaterials. However, the traditional introduction of reducing agents or other additives during the synthesis of Ag‐SF composite MFs potentially affects their structure and antibacterial properties. Facile, green and effective methods for the preparation of Ag‐SF MFs with enhanced antibacterial properties are therefore highly desired. In this study, Ag NPs were uniformly in‐situ deposited onto the optimized SF MFs by adjusting the pH and duration conditions under the guidance of green chemistry. The loaded Ag NPs have a good dispersibility and an average size of ~10 nm. The stability of SF MFs after the deposition of Ag NPs and the crystalline features of the loaded Ag NPs have been carefully investigated. Moreover, antibacterial experiments confirmed that Ag‐SF MFs exhibited superior antibacterial activities. After co‐incubating Ag‐SF MFs with L929 cells, the cell viability reached 90%, demonstrating the great biocompatibility of the modified fibers. This green in‐situ synthetic method will promote the further medical use of Ag‐SF MFs in antibacterial fields.

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A comprehensive review on silver nanoparticles: Synthesis approaches, characterization techniques, and recent pharmaceutical, environmental, and antimicrobial applications

Cited by 28 publications

References 195 publications

Biogenic silver nanoparticles' antibacterial activity and cytotoxicity on human hepatocarcinoma cells (Huh-7)

Biogenic silver nanoparticles' antibacterial activity and cytotoxicity on human hepatocarcinoma cells (Huh-7)

Novel Carbon Dots Derived from Moutan Cortex Significantly Improve the Solubility and Bioavailability of Mangiferin

In‐Situ and Green Synthesis of Silk Fibroin‐Silver Nanoparticles Composite Microfibers for Enhanced Antibacterial Applications

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