A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

Sadat, Zahra; Farrokhi-Hajiabad, Farzaneh; Lalebeigi, Farnaz; Naderi, Nooshin; Gorab, Mostafa Ghafori; Cohan, Reza Ahangari; Eivazzadeh‐Keihan, Reza; Maleki, Ali

doi:10.1039/d2bm01308h

Cited by 55 publications

(23 citation statements)

References 219 publications

(192 reference statements)

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“…Hb was then decorated onto the nanosheets using PDA coating as the chemical linkage, finally forming BC-PDA-Hb (BCPH) NSs. Compared with previous work, 45,46 the formed BCPH NSs had no fluorescent emission, good photothermal conversion performance, excellent PA imaging capability, and strong Fenton reaction activity. The Fe 2+ carried in Hb can convert H 2 O 2 overexpressed in tumor microenvironment (TME) to toxic • OH, eliminating tumor cells via CDT.…”

Section: ■ Introductionmentioning

confidence: 67%

Hemoglobin-Decorated Boron-Carbon Nanosheets with Catalytic Ability and Near-Infrared II Light Response for Tumor Photothermal-Chemodynamic Therapy

Chen

Zhang

Ouyang

et al. 2023

ACS Appl. Nano Mater.

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Carbon-based nanomaterials are a kind of attractive photothermal agents (PTAs) for tumor photothermal therapy (PTT). However, their inherent fluorescent emission always compromises the photothermal conversion efficiency and is a huge obstruction that needs to be solved. Herein, a kind of hemoglobin (Hb)-decorated boron-carbon nanosheets (BC NSs) was designed and developed with catalytic ability and near-infrared II light-responsive performance for photoacoustic (PA) imaging-guided synergistic tumor PTT/chemodynamic therapy (CDT). BC NSs were synthesized from biomass gelatin, coated with a polydopamine (PDA) layer, and decorated with Fenton agent Hb. The formed BC-PDA-Hb (BCPH) NSs had no fluorescent emission, high photothermal conversion performance (47.8% under 1064 nm laser irradiation), and excellent PA imaging capability. The Fe2+ carried in Hb can react with intratumoral overexpressed H2O2 to generate toxic hydroxyl radicals. In vitro and in vivo data revealed that BCPH NSs can achieve effective tumor elimination through synergistic PTT/CDT without detectable adverse effects on normal tissues. This work offers an effective strategy to develop carbon-based nanomedicines owning promoted photothermal performance and high biocompatibility for tumor theranostic applications.

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Section: ■ Introductionmentioning

confidence: 67%

Hemoglobin-Decorated Boron-Carbon Nanosheets with Catalytic Ability and Near-Infrared II Light Response for Tumor Photothermal-Chemodynamic Therapy

Chen

Zhang

Ouyang

et al. 2023

ACS Appl. Nano Mater.

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“…There was evidence that GO-based materials could enhance cell adhesion, growth, and proliferation; these materials have been used in the fields of wound healing, tissue engineering scaffolds, and drug-delivery systems. 77,78 However, a few studies showed that SGO formed by prolonged ultrasonic treatment was easier to internalize and induce oxidative stress or irreversible cell damage without causing significant proliferation changes in cells. 7,79 Therefore, we further evaluated cellular oxidative stress injury using the DCFH-DA assay.…”

Section: Resultsmentioning

confidence: 99%

Controlling the size of GO in GO/nAg nanocomposite coatings on orthodontic nickel–titanium alloy toward excellent anti-corrosion, antibacterial, and tribological properties

Dai

Zhang

2023

Biomater. Sci.

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“…Furthermore, conductive hydrogels can simulate the physiological environment of electroactive tissues, regulate the spinal cord microenvironment, and reconstruct the signal transduction pathway of damaged nerves, thus promoting nerve regeneration. Currently, a variety of conductive materials, such as polyaniline (PANI), polypyrrole (PPy), polythiophene (PTH), metal nanoparticles and carbon-based materials, have been introduced to construct conductive hydrogels [15][16][17][18][19]. Among them, PANI is widely used in tissue engineering because of its reasonable structural design, good water solubility and good electrical activity.…”

Section: Introductionmentioning

confidence: 99%

An injectable, self-healing, electroconductive hydrogel loaded with neural stem cells and donepezil for enhancing local therapy effect of spinal cord injury

Liu

Cui

et al. 2023

Preprint

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Background Spinal cord injury (SCI) is a serious injury with high mortality and disability rates, and there is no effective treatment at present. It has been reported that some treatments have positive effects in promoting neurological recovery, such as drug intervention and stem cell transplantation. Although those treatments are effective for nerve regeneration, many drawbacks have limited their development, such as low stem cell survival rates and side effects caused by systemic medication. In recent years, injectable hydrogel materials have been widely used in tissue engineering due to their good biocompatibility, biodegradability, controllable properties, and low invasiveness. The treatment strategy of injectable hydrogels combined with stem cells or drugs has made some progress in SCI repair, which can overcome the defects existing in traditional drugs and stem cell therapy. Method In this study, a novel injectable electroactive hydrogel (NGP) based on sodium hyaluronate oxide (SAO) and polyaniline-grafted gelatin (NH2-Gel-PANI) was developed to load neural stem cells (NSCs) and donepezil (DPL) to facilitate nerve regeneration post-SCI. To evaluate the potential of the prepared NGP hydrogel in SCI repair application, the surface morphology, self-repairing properties, electrical conductivity and cytocompatibility of the resulting hydrogel were analyzed. Meanwhile, we evaluated the neural repair ability of NGP hydrogels loaded with DPL and NSCs using a rat model of spinal cord injury. Result The NGP hydrogel has a suitable pore size, good biocompatibility, excellent conductivity, injectable and self-repairing properties, and its degradation rate matches the repair cycle of spinal cord injury. At the same time, DPL could be released continuously and slowly in the NGP hydrogel; thus, the NGP hydrogel could be used as an excellent carrier of drugs and cells. The results of in vitro cell experiments showed that the NGP hydrogel had good cytocompatibility and could significantly promote neuronal differentiation and axon growth of NSCs, and the hydrogel loaded with DPL could significantly enhance this effect. More importantly, the NGP hydrogel loaded with DPL showed a significant inhibitory effect on astrocyte differentiation of NSCs in vitro. Animal experiments show that the combination of NGP hydrogel + DPL + NSCs group showed the best therapeutic effect on the recovery of motor function and nerve conduction function in rats. NGP hydrogel-loaded NSCs and DPL not only significantly increased the myelin sheath area, number of new neurons and axon area but also minimized the area of the cystic cavity and glial scar and promoted neural circuit reconstruction. Conclusions The DPL and NSCs-laden electroactive hydrogel developed in this study is an ideal biomaterial for the treatment of traumatic spinal cord injury.

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A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

Abstract: A wound is defined as damage to the integrity of biological tissue, including skin, mucous membranes, and organ tissues. The treatment of these injuries is an important challenge for medical...

Cited by 55 publications

References 219 publications

Hemoglobin-Decorated Boron-Carbon Nanosheets with Catalytic Ability and Near-Infrared II Light Response for Tumor Photothermal-Chemodynamic Therapy

Hemoglobin-Decorated Boron-Carbon Nanosheets with Catalytic Ability and Near-Infrared II Light Response for Tumor Photothermal-Chemodynamic Therapy

Controlling the size of GO in GO/nAg nanocomposite coatings on orthodontic nickel–titanium alloy toward excellent anti-corrosion, antibacterial, and tribological properties

An injectable, self-healing, electroconductive hydrogel loaded with neural stem cells and donepezil for enhancing local therapy effect of spinal cord injury

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