A comprehensive review on the indazole based derivatives as targeted anticancer agents

Puri, Sachin; Sawant, Siddhi; Juvale, Kapil

doi:10.1016/j.molstruc.2023.135327

Cited by 10 publications

(1 citation statement)

References 114 publications

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“…[33] Linifanib, Pazopanib, and Axitinib are among the indazole containing tyrosine kinase inhibitors (Figure 1). [34,35] Indazole is a nitrogen containing heterocyclic compound that has been synthesized and used clinically. [36] Various heterocyclic clubbed indazoles were reported to target VEGFR-2, [37][38][39][40] FGFR, [41,42] EGFR, [43,44] GSK-3 [45] and AURK.…”

Section: Introductionmentioning

confidence: 99%

Development of Novel Indazolyl‐Acyl Hydrazones as Antioxidant and Anticancer Agents that Target VEGFR‐2 in Human Breast Cancer Cells

Parameshwaraiah,

Shivakumar,

et al. 2024

Chemistry & Biodiversity

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Cancer is the second biggest cause of death worldwide and drug design is becoming increasingly important in the development of novel therapies. The overexpression of VEGFR‐2 in a variety of cancer cells promotes a cascade of cellular responses for activation that improve cell survival, growth, and proliferation. Scientists are working on targeting tyrosine kinases therapeutically and to develop safe, effective drugs that do not affect healthy cells. Heterocycles are common structural elements in medicinal chemistry and commercially available medications that can target several biological pathways and induce cell death in cancer cells. In this article, we discuss the biological evaluations of indazolyl‐acyl hydrazones as antioxidant and anticancer agents. 4e and 4j showed better inhibitory activity in radical scavenging assays (DPPH and FRPA). The titled compounds were subjected to cytotoxic studies using MCF‐7 cells using alamarBlue assay, and found that the compounds 4f and 4j had a better IC50 values 15.83 µM and 5.72 µM, respectively. In silico docking study revealed the favorable binding energies of ‐7.30 kcal/mol and ‐8.04 kcal/mol for compounds towards Vascular Endothelial Growth Factor Recaptor‐2 (VEGFR‐2), respectively. In conclusion, we have synthesized antioxidant and anticancer agents that target VEGFR‐2 in breast cancer cells.

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Section: Introductionmentioning

confidence: 99%

Development of Novel Indazolyl‐Acyl Hydrazones as Antioxidant and Anticancer Agents that Target VEGFR‐2 in Human Breast Cancer Cells

Parameshwaraiah,

Shivakumar,

et al. 2024

Chemistry & Biodiversity

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Electrochemical Oxidative Ring‐Opening Reactions of 2H‐Indazoles with Alcohols to Obtain Ortho‐alkoxycarbonylated Azobenzenes

Hu,

Liu,

Feng

et al. 2024

Adv Synth Catal

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A strategy for synthesis of azo‐derived compounds by electrochemical oxidative ring‐opening reactions of 2H‐indazoles with alcohols is reported. The reactions are carried out under galvanostatic electrolysis conditions in an undivided cell without the use of transition metal catalysts. On the basis of cyclic voltam¬metry and control experiments, a plausible mechanism for this ring‐opening reaction involving the radical pathway is proposed. Furthermore, various 2H‐indazoles and alcohols are suitable in this system, giving the desired ortho‐alkoxycarbonylated azobenzenes in 9‐84% yields.

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Combined Gold and Photoredox Catalysis: Synthesis of 3‐Alkenyl‐2H‐Indazoles from 2‐Alkynylazobenzenes

Mañas,

Merino

2024

Adv Synth Catal

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We disclose the intramolecular synthesis of 3‐alkenyl‐2<i>H</i>‐indazoles from 2‐alkynylazobenzenes promoted by a dual catalysis using AuCl3 and a ruthenium photocatalyst under irradiation with visible light. This reaction goes through a hydroamination of the alkynyl fragment. The yields are governed by the electronic factors. Control experiments and DFT calculations suggest that a radical and polar mechanisms are operating in parallel. This transformation goes through first formation and C‐N bond and 1,2‐hydride shift. Derivatization was also carried out to extend the versatility of this methodology.

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A comprehensive review on the indazole based derivatives as targeted anticancer agents

Cited by 10 publications

References 114 publications

Development of Novel Indazolyl‐Acyl Hydrazones as Antioxidant and Anticancer Agents that Target VEGFR‐2 in Human Breast Cancer Cells

Development of Novel Indazolyl‐Acyl Hydrazones as Antioxidant and Anticancer Agents that Target VEGFR‐2 in Human Breast Cancer Cells

Electrochemical Oxidative Ring‐Opening Reactions of 2H‐Indazoles with Alcohols to Obtain Ortho‐alkoxycarbonylated Azobenzenes

Combined Gold and Photoredox Catalysis: Synthesis of 3‐Alkenyl‐2H‐Indazoles from 2‐Alkynylazobenzenes

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