Oil and gas wells (OGWs) with integrity failures can be a conduit for methane and contaminant leakage to groundwater aquifers, surface water bodies and the atmosphere. Recent reviews have addressed OGW leakage but focused on specific types of wells (conventional/unconventional) or specific geographic regions. Here, we conduct a literature review and focus on factors and policies affecting leakage of active and abandoned OGWs, studies quantifying OGW methane emissions, and leakage repair and emission reduction options. Of the 38 factors reviewed here in published literature, studies find that 15 (39%) factors, including geographic location, well deviation, casing quality and plugging status consistently affect OGW leakage. For 15 (39%) factors, including surface casing depth, well elevation and land cover, one or two studies show that they do not affect OGW leakage. For the remaining eight (21%) factors, including well age, studies show conflicting results. Although increased frequency of well monitoring and repair can lead to reduced OGW leakage, several studies indicate that monitoring and repair requirements are not always enforced. Moreover, we find that while 27 studies quantify OGW methane emissions to the atmosphere at the oil and gas wellhead scale, there still are major gaps in the geographical distribution of the collected data, especially for abandoned and orphaned wells. Although studies measuring abandoned wells may include measurements from orphaned wells, these measurements are not separated by well status (orphaned/abandoned), which is important for policy makers aiming to plug thousands of orphaned wells. To repair OGW leakage, we find that most studies focus on well cement and casing repair, and other studies focus on improving the cement mixture to avoid the need for repairs. Alternatives to cement and casing repair for methane emission reductions, such as soil methane oxidation to reduce leakage from OGWs may be effective, but their widespread applicability requires further study. Overall, our review of factors affecting OGW leakage can be used to guide OGW leakage monitoring and repair policies to target wells with high leakage potential, thereby reducing climate and environmental impacts.