A comprehensive review on the nutritional and therapeutical aspects of Stevia rebaudiana bertoni

Nathalie, Escutia-Lopez Karina; Elena, Sanchez Pardo Ma; Escobedo, Rosalva Mora

doi:10.15406/jabb.2019.06.00207

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Steviol glycosides are composed of steviol, stevioside, rebaudioside A, B, C, D, E, and F, and dulcoside. Stevia rebaudiana Bertoni and its components have been used for medicinal and commercial purposes for a long time as they are natural and have no calories [8]. Many studies demonstrated that Stevia rebaudiana Bertoni decreased plasma glucose concentrations in diabetic rats compared to control [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effects of Stevioside on the Expressions of GLUT 1, GLUT 3, and GLUT 4 Proteins in Diabetic Rat Placenta

2023

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The placenta provides maternal–fetal nutrient transport. The primary source of energy for fetus development is glucose and maternal–fetal glucose transport occurs through glucose transporters (GLUTs). Stevioside, a component of Stevia rebaudiana Bertoni, is used for medicinal and commercial purposes. We aim to determine the effects of stevioside on GLUT 1, GLUT 3, and GLUT 4 proteins expressions in diabetic rat placentas. The rats are divided into four groups. A single dose of streptozotocin (STZ) is administered to form the diabetic groups. Pregnant rats receive stevioside to form the stevioside and diabetic + stevioside groups. According to immunohistochemistry results, GLUT 1 protein is found in both the labyrinth and junctional zones. GLUT 3 protein is limited in the labyrinth zone. GLUT 4 protein is detected in trophoblast cells. According to Western blotting results, on the 15th and 20th days of pregnancy, there is no difference in the expression of GLUT 1 protein between groups. On the 20th day of pregnancy, the expression of GLUT 3 protein in the diabetic group is statistically higher compared to the control group. On the 15th day and 20th day of pregnancy, the expression of GLUT 4 protein in the diabetic group is statistically lower compared to the control group. Insulin levels in blood samples derived from rat abdominal aorta are determined by the ELISA method. According to the ELISA results, there is no difference in insulin protein concentration between groups. Stevioside treatment reduces GLUT 1 protein expression under diabetic conditions.

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Section: Introductionmentioning

confidence: 99%

Effects of Stevioside on the Expressions of GLUT 1, GLUT 3, and GLUT 4 Proteins in Diabetic Rat Placenta

2023

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The immunomodulator effect of Stevia rebaudiana Bertoni mediated by TNF‐α and IL‐1β in peripheral blood in diabetic rats

Cebeci,

Katirci,

Karhan

et al. 2024

Food Science & Nutrition

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Stevia rebaudiana Bertoni, which is a medicinal plant used in the treatment of diabetes, was the focus of this study aiming to investigate its immunomodulatory properties in diabetes. To form the diabetes group, rats were injected intraperitoneally with STZ and rats with blood glucose levels above 200 mg/dL 2 days after STZ injection were included in the diabetes group. To form the stevia and diabetes + stevia groups, stevia was administered daily by gavage to both healthy and diabetic rats for 28 days. At the end of 28 days, the levels of interleukin‐1 beta and tumor necrosis factor‐alpha in the blood were measured by ELISA. CD3, CD4, and CD8 protein levels in the blood were determined by flow cytometry. Rat body weight increased in the diabetes +25 mg/kg bW stevia group compared with the diabetes group. Blood glucose levels were significantly decreased in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (**p < .01). IL‐1β cytokine levels decreased significantly in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (**p < .01). TNF‐α cytokine levels decreased significantly in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (**p < .01). The amount of CD8 + T cells decreased significantly in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (*p < .05). The stevia diet leads to a reduction in peripheral circulating cytotoxic T cells and proinflammatory cytokines interleukin‐1 beta and tumor necrosis factor‐alpha under hyperglycemic conditions.

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Nutritional and Medicinal Properties of Stevia Rebaudiana

Ahsan¹

2020

CRDOJ

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Researches on new molecules with the least toxic effects and better potency is on its way and more attention is being given upon medicinal plants for forcing away the above problems. Medicinal plants have been recognized as potential drug candidates. Stevia, a natural sweetener with medicinal properties and also having nutritional, therapeutic and industrial importance is being used all over the world. Stevia rebaudiana leaves are usually referred to as candy, sweet and honey leaves. Diterpene glycosides are responsible for its high sweetening potential of leaves. The phytochemical properties of bioactive chemicals present in stevia leaves are involves in maintaining the physiological functions of human body. Paper also highlights the importance of nutritional aspects of dried stevia leaves, metabolism of stevia, effects of it consumption on human health and clinical studies related to stevia ingestion. Various medicinal properties of stevia leaves discussed in paper like anti-hyperglycemia, anti-oxidative, hypotensive, nephro-protective, hepato protective, antibacterial and antifungal. Basic purpose of this review to understand the medicinal potential of stevia and its acceptance as a significant raw material for human diet.

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A comprehensive review on the nutritional and therapeutical aspects of Stevia rebaudiana bertoni

Cited by 3 publications

References 28 publications

Effects of Stevioside on the Expressions of GLUT 1, GLUT 3, and GLUT 4 Proteins in Diabetic Rat Placenta

Effects of Stevioside on the Expressions of GLUT 1, GLUT 3, and GLUT 4 Proteins in Diabetic Rat Placenta

The immunomodulator effect of Stevia rebaudiana Bertoni mediated by TNF‐α and IL‐1β in peripheral blood in diabetic rats

Nutritional and Medicinal Properties of Stevia Rebaudiana

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