A comprehensive review on the biotechnological intervention for deciphering the pharmacological and other multifarious properties of miracle tree Moringa oleifera

Jain, Ajay; Yugandhar, Poli; Goud, Muddapuram Deeksha; Ravi, Rajiv; Bhaskaran, Sinilal; Wang, Xiaowen; Das, Shabari Sarkar; Gupta, Swati; Jain, Rohit; Kachhwaha, Sumita; Sharma, Preeti; Gour, Vinod Singh; Sarkar, Ananda K.; Sahi, Shivendra V.; Kothari, S. L.

doi:10.1016/j.indcrop.2021.113807

Cited by 6 publications

(5 citation statements)

References 137 publications

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“…While some studies underscored the low toxicity of different parts of moringa, such as the leaves [ 171 ], Liu et al [ 54 ] pointed out that moringa is toxic at certain doses and overuse can cause genotoxicity, with a few studies suggesting its hepatotoxicity and nephrotoxicity as well as potential blood toxicity. Jain et al [ 83 ] stressed that “ Largely, the pharmacological applications of various bioactive phytochemicals from M. oleifera have been based on anecdotes and the mechanistic details governing their activities have been elusive ”. That implies that further studies are needed to provide the necessary evidence supporting the use of moringa in medicine.…”

Section: Resultsmentioning

confidence: 99%

“…Further 134 documents were excluded after the analysis of abstracts as they did not meet at least one of the eligibility/inclusion criteria: 53 did not deal with Africa; 69 dealt with other species of moringa, e.g., Moringa stenopetala , Moringa peregrina , or Moringa ovalifolia (articles dealing with Moringa pterygosperma , which is considered erroneously a synonym of M. oleifera , were considered eligible); and 12 were editorial materials. Finally, the analysis of full texts led to the exclusion of 103 documents, including 47 reviews [ 35 , 37 , 38 , 41 , 42 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 63 , 64 , 67 , 70 , 71 , 72 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 ].…”

Section: Methodsmentioning

confidence: 99%

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Research on Moringa (Moringa oleifera Lam.) in Africa

El Bilali,

Dan Guimbo,

Nanema

et al. 2024

Plants

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While Moringa oleifera Lam. is gaining importance in Africa, especially sub-Saharan Africa, it is unclear whether research is following the quick pace of its development on the continent. Therefore, this article analyzes the landscape of research dealing with moringa in Africa. This systematic review draws upon 299 eligible articles identified through a search carried out on the Web of Science in April 2023. Research on M. oleifera is rather recent in Africa but interest is increasing among scholars. While the research field is multidisciplinary and cross-sectoral, the literature seems to focus on biological and environmental sciences. Moreover, research is performed mainly in South Africa, Nigeria, Egypt, and Ghana. The analysis suggests a significant potential contribution of moringa to food security and nutrition, climate change mitigation/adaptation, farming systems resilience, and livelihoods. Its versatility and diverse applications and uses make moringa particularly interesting for developing countries, such as African ones. However, this review also underscores some factors hindering its development. Therefore, there is a need to strengthen research on moringa to unlock its potential in Africa. Investments in research, innovation, and development can help address the many challenges that Africa faces and contribute to the transition towards sustainable and resilient food systems.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Research on Moringa (Moringa oleifera Lam.) in Africa

El Bilali,

Dan Guimbo,

Nanema

et al. 2024

Plants

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“…About 8 kg of the fresh leaves (with stem removed) yields ~1 kg of dried leaf powder (www.moringanews.org). MO leaves, rich in various bioactive polyphenols, novel polysaccharides, phytochemicals, and secondary metabolites, are extensively used for their multiferous nutraceutical and pharmacological properties, as a functional food or other products for health care, and as an additive in animal diets to improve the meat quality [10,[94][95][96][97][98][99]. Ultra-high-performance liquid chromatography with a diode array coupled to electrospray ionization mass spectrometry (UPLC-ESI-QTOFMS) analysis of the methanol extract from MO leaves revealed a significant influence of the seasonal variations on the production of secondary metabolites, and therefore autumn and summer were recommended to be the best harvesting seasons [100].…”

Section: Breedingmentioning

confidence: 99%

“…MO is commonly known as ben oil tree, drumstick tree, or horseradish tree and is indigenous to northwest India and is now cultivated and/or naturalized in semi-arid, tropical, and subtropical regions of several countries in Africa, Asia, Australia/Oceania, Europe, North America, Central America, and South America, and the Caribbean (Figure 1). MO's wide assortment of culinary, nutraceutical, pharmacological, and phytochemical properties, providing remedies for various ailments and chronic diseases, and applications in biofuel production, environmental management, and water treatment has earned it several epithets (crops for the future, natural gift, mother's best friend, and never die) [3][4][5][6][7][8][9][10]. MO plays an important role in the United Nations Sustainable Development Goal 2 (SDG 2) to achieve food security by shifting towards improved nutrition and healthier diets from the varied sustainable agricultural system [11].…”

Section: Introductionmentioning

confidence: 99%

Miracle Tree Moringa oleifera: Status of the Genetic Diversity, Breeding, In Vitro Propagation, and a Cogent Source of Commercial Functional Food and Non-Food Products

Alavilli

Yugandhar

Verma

et al. 2022

Plants

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Moringa oleifera Lam. (MO) is a fast-growing drought-resistant tree belonging to the family Moringaceae and native to the Indian subcontinent and cultivated and/or naturalized worldwide with a semi-arid climate. MO is also popularly known as a miracle tree for its repertoire of nutraceutical, pharmacological, and phytochemical properties. The MO germplasm is collected, conserved, and maintained by various institutions across the globe. Various morphological, biochemical, and molecular markers are used for determining the genetic diversity in MO accessions. A higher yield of leaves and pods is often desirable for making various products with commercial viability and amenable for trade in the international market. Therefore, breeding elite varieties adapted to local agroclimatic conditions and in vitro propagation are viable and sustainable approaches. Here, we provide a comprehensive overview of MO germplasm conservation and various markers that are employed for assessing the genetic diversity among them. Further, breeding and in vitro propagation of MO for various desirable agronomic traits are discussed. Finally, trade and commerce of various functional and biofortified foods and non-food products are enumerated albeit with a need for a rigorous and stringent toxicity evaluation.

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“…MO is a common plant grown as a food source and has been used in African traditional medicine for centuries (Vergara-Jimenez et al, 2017;Bancessi et al, 2020). MO is considered a famine food because of its high nutrient content and resistance to drought, and every part of the tree is used (Saini et al, 2016;Bao et al, 2020;Mabrouki et al, 2020;Jain et al, 2021). There is increasing interest in the role of non-coding miRNAs in posttranscriptional regulation (Chin et al, 2016;Cui et al, 2017;Lundstrom, 2017;Morales et al, 2017;Hou et al, 2018;Yao et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Exogenous miRNAs from Moringa oleifera Lam. recover a dysregulated lipid metabolism

Roglia

Potestà

Minchella

et al. 2022

Front. Mol. Biosci.

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A balanced diet is critical for human health, and edible plants play an important role in providing essential micronutrients as well as specific microRNAs (miRNAs) that can regulate human gene expression. Here we present the effects of Moringa oleifera (MO) miRNAs (mol-miRs) on lipid metabolism. Through in silico studies we identified the potential genes involved in lipid metabolism targeted by mol-miRs. To this end, we tested the efficacy of an aqueous extract of MO seeds (MOES), as suggested in traditional African ethnomedicine, or its purified miRNAs. The biological properties of MO preparations were investigated using a human derived hepatoma cell line (HepG2) as a model. MOES treatment decreased intracellular lipid accumulation and induced apoptosis in HepG2. In the same cell line, transfection with mol-miRs showed similar effects to MOES. Moreover, the effect of the mol-miR pool was investigated in a pre-obese mouse model, in which treatment with mol-miRs was able to prevent dysregulation of lipid metabolism.

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A comprehensive review on the biotechnological intervention for deciphering the pharmacological and other multifarious properties of miracle tree Moringa oleifera

Cited by 6 publications

References 137 publications

Research on Moringa (Moringa oleifera Lam.) in Africa

Research on Moringa (Moringa oleifera Lam.) in Africa

Miracle Tree Moringa oleifera: Status of the Genetic Diversity, Breeding, In Vitro Propagation, and a Cogent Source of Commercial Functional Food and Non-Food Products

Exogenous miRNAs from Moringa oleifera Lam. recover a dysregulated lipid metabolism

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