A comprehensive review on the pharmacological properties of Diplazium esculentum, an edible fern

Abstract

Diplazium esculentum (Family: Athyriaceae), one of the most popular wild edible fern, is considered as a pharmacologically diverse ethnomedicinal plant. The coiled fronds and young leaves of this plant have a wide range ethnomedicinal uses in folk medicine around the world directed for a number of ailments. The present article is the first comprehensive review on the pharmacological activities of this particular edible fern. The structural formulas of all the chemical constituents identified and isolated so far from D. esculentum are also provided in the present review. The most thoroughly studied pharmacological activities viz., antioxidant, antimicrobial, immunomodulatory, neuromodulatory, anti-fertility, cytotoxic, etc.) of the D. esculentum extracts have been discussed. This comprehensive review will be of help for the future researchers investigating for more potent compounds and their pharmacological activities.

Enhancing Therapeutic Efficacy of Donepezil, an Alzheimer’s Disease Drug, by Diplazium esculentum (Retz.) Sw. and Its Phytochemicals

“…Different types of D. esculentum solvent extractions have been investigated regarding their pharmacological properties, especially for neuromodulatory effects both in vitro and in vivo [ 30 ]. D. esculentum ethanolic extract (1.25 mg/mL) inhibited AChE, BChE, and BACE-1 at 46.15, 53.12, and 55.91% [ 17 ], while a 70% methanolic extract inhibited AChE with an IC 50 value of 272.97 µg/mL [ 31 ].…”

“…Fortunately, kaempferol, quercetin, and rosmarinic acid-the top three phytochemicals found in DE (Table 1)-have also been reported to cross the BBB [29], highlighting the possibility that these compounds contributed to the rough eye improvement in Drosophila (Figure 5). Different types of D. esculentum solvent extractions have been investigated regarding their pharmacological properties, especially for neuromodulatory effects both in vitro and in vivo [30]. D. esculentum ethanolic extract (1.25 mg/mL) inhibited AChE, BChE, and BACE-1 at 46.15, 53.12, and 55.91% [17], while a 70% methanolic extract inhibited AChE with an IC 50 value of 272.97 µg/mL [31].…”

Ethnopharmacology and Species diversity of Pteridophyta in Cyathea Park, Bali: A Field study and Literature Review

“…The plant possesses antiin ammatory and antioxidant chemicals that can help cure topical dermatitis and decrease in ammation and oxidative stress in the skin. It also has a poisonous impact on insects through contact poisoning, respiratory accretion, and acetylcholinesterase inhibition (Roy & Chaudhuri, 2020;Semwal et al, 2021).…”

Utilization of Pteridophyta species in Cyathea Park, Bali, as traditional medicine agents: A field study and meta-synthesis review

“…The plant possesses anti-inflammatory and antioxidant chemicals that can help cure topical dermatitis and decrease inflammation and oxidative stress in the skin. It also has a poisonous impact on insects through contact poisoning, respiratory accretion, and acetylcholinesterase inhibition (Roy and Chaudhuri, 2020;Semwal et al, 2021).…”