A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health

Abstract

Curcumin is the most important active component in turmeric extracts. Curcumin, a natural monomer from plants has received a considerable attention as a dietary supplement, exhibiting evident activity in a wide range of human pathological conditions. In general, curcumin is beneficial to human health, demonstrating pharmacological activities of anti-inflammation and antioxidation, as well as antitumor and immune regulation activities. Curcumin also presents therapeutic potential in neurodegenerative, cardiovascular and cerebrovascular diseases. In this review article, we summarize the advancements made in recent years with respect to curcumin as a biologically active agent in malignant tumors, Alzheimer’s disease (AD), hematological diseases and viral infectious diseases. We also focus on problems associated with curcumin from basic research to clinical translation, such as its low solubility, leading to poor bioavailability, as well as the controversy surrounding the association between curcumin purity and effect. Through a review and summary of the clinical research on curcumin and case reports of adverse effects, we found that the clinical transformation of curcumin is not successful, and excessive intake of curcumin may have adverse effects on the kidneys, heart, liver, blood and immune system, which leads us to warn that curcumin has a long way to go from basic research to application transformation.

Thermo-Sensitive Poly (N-isopropylacrylamide-co-polyacrylamide) Hydrogel for pH-Responsive Therapeutic Delivery

“…However, due to its low solubility and poor bioavailability, its therapeutic application is limited [ 22 ]. Cur has been discovered to have a variety of biological and anticancer activities, including antibacterial, antioxidant, and anti-inflammatory [ 23 ]. Curcumin has been studied for its ability to alleviate various cancers, including colon, and breast cancer [ 24 ].…”

Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

“…Altogether, these studies, and others, showed that curcumin may be effective in controlling circulating blood glucose concentrations and has the potential to slow the progression of type 2 diabetes (15,(70)(71)(72). Turmeric is a safe food that healthy people can eat in moderation without getting sick (16).…”

“…That is, it is used for nutrients that indicate the absorption value. A food with a high ORAC value is more antioxidants, protects against cancer, and slows aging (16).…”

“…Because of the dye substance's resemblance to saffron, it is used in the production of zerde as a low-price alternative. Even though the first application of turmeric in history was as a dyestuff for fabrics and yarns, its current use for health purposes has largely surpassed any other application, including spices (16).…”

Application study of curcumin fluorescent complex coated with pharmaceutical excipients for cell imaging

“…The research and application of acrylic resin-based pharmaceutical excipients are very extensive, especially in the field of pharmacy ( Bettencourt et al, 2010 ; Villanova et al, 2011 ; Liu S. et al, 2022 ). In view of the shortcomings of many drugs directly administered, coating technology can effectively solve such problems.…”