A comprehensive review on traditional uses, chemical compositions, pharmacology properties and toxicology of Tetrastigma hemsleyanum

Abstract

Ethnopharmacological relevance Tetrastigma hemsleyanum Diels et Gilg ( T.hemsleyanum ), a rare herbal plant distributed in subtropical areas of mainland China, has become a focus of scientific attention in recent years because of its high traditional value, including uses for treatment of children with fever, pneumonia, asthma, rheumatism, hepatitis, menstrual disorders, scrofula, and pharynx pain. Aim This systematic review aims to provide an insightful understanding of traditional uses, chemical composition, pharmacological effect and clinical application of T. hemsleyanum , and lay a foundation for the further study and for the utilization of T. hemsleyanum resource. Materials and methods A domestic and overseas literature search in known databases was conducted for published articles using the relevant keywords. Results One hundred and forty-two chemical constituents identified from T. hemsleyanum have been reported, including flavonoids, phenolic acids, polysaccharide, organic acids, fatty acids, terpenoids, steroids, amino acid and others. Among these components, flavonoids and polysaccharides were the representative active ingredients of T. hemsleyanum , which have been widely investigated. Modern pharmacological studies have shown that these components exhibited various pharmacological activities, such as anti-inflammatory, antioxidant, antivirus, antitumor, antipyretic, anti-hepatic injury, immunomodulatory, antibacterial etc. Moreover, different toxicological studies indicated that the clinical dosage of T. hemsleyanum was safe and reliable. Conclusions Modern pharmacological studies have well supported and clarified some traditional uses, and T. hemsleyanum has a good prospect for the development of new drugs due to these outstanding properties. However, the present findings did not provide an in-depth evaluation of bioactivity of the extracts, the composition of its active extracts was not clear. Moreover, they were insufficient to satisfactorily explain some mechanisms of action. Data regarding many aspects of T. hemsleyanum , such as links between the traditional uses and bioactivities, pharmacokinetics, quality control standard and the clinical value of active compositions is still limited which need more attention.

Investigating the active compounds and mechanism of HuaShi XuanFei formula for prevention and treatment of COVID-19 based on network pharmacology and molecular docking analysis

“…It can exert numerous bioactivities, including antivirus, anti-inflammatory, immunoregulatory, enhancing immune function, antibacterial, and antioxidant, etc. [ 6 ]. Flavonoids of SYQ, such as kaempferol, quercetin, procyanidin dimmer, and epicatechin had an antiviral effect on H1N1 influenza virus [ 7 ].…”

Transcriptome and Metabolome Integrated Analysis of Two Ecotypes of Tetrastigma hemsleyanum Reveals Candidate Genes Involved in Chlorogenic Acid Accumulation

“…T. hemsleyanum is a valuable traditional herb known as “San ye qing (SYQ)”, and it is peculiar to China; the whole plant has been widely used as a broad-spectrum antibiotic material against fever and inflammation. Modern pharmacological studies have shown that T. Hemsleyanum also has antioxidant, antivirus, antitumor, immunomodulatory and hypoglycemic effects [ 3 ].…”

Multi-omics analyses revealed key factors involved in fluorescent carbon-dots-regulated secondary metabolism in Tetrastigma hemsleyanum

“…T.hemsleyanum is a herbal plant distributed in tropical to subtropical regions, mainly in mainland China. Flavonoids and phenolic acids were the main active secondary metabolic ingredients of T. hemsleyanum [ 43 ]. Total favonoids from T. hemsleyanumon were reported to exert anti-infammatory effects on Con A-induced hepatitis in mice [ 44 ].…”