A comprehensive set of ER protein disulfide isomerase family members supports the biogenesis of proinflammatory interleukin 12 family cytokines

Mideksa, Yonatan G.; Aschenbrenner, Isabel; Fux, Anja; Kaylani, Dinah; Weiß, Caroline A. M.; Nguyen, Tuan‐Anh; Bach, Nina C.; Lang, Kathrin; Sieber, Stephan A.; Feige, Matthias J.

doi:10.1016/j.jbc.2022.102677

Cited by 5 publications

(2 citation statements)

References 66 publications

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“…In contrast, the expression of TXNDC5 is reduced in kidney cells infected with a pseudorabies vaccine strain [113]. Additionally, the interaction between TXNDC5 and IL12A, IL23α, AGO2 and ITPR1 has been observed in kidney cells [44,85,114]. In summary, these results suggest that targeting TXNDC5 could be a novel and powerful approach to treating or preventing renal fibrosis and RCC.…”

Section: Txndc5 and Kidney Cancermentioning

confidence: 85%

Thioredoxin Domain Containing 5 (TXNDC5): Friend or Foe?

Bidooki,

Navarro,

Fernandes

et al. 2024

CIMB

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This review focuses on the thioredoxin domain containing 5 (TXNDC5), also known as endoplasmic reticulum protein 46 (ERp46), a member of the protein disulfide isomerase (PDI) family with a dual role in multiple diseases. TXNDC5 is highly expressed in endothelial cells, fibroblasts, pancreatic β-cells, liver cells, and hypoxic tissues, such as cancer endothelial cells and atherosclerotic plaques. TXNDC5 plays a crucial role in regulating cell proliferation, apoptosis, migration, and antioxidative stress. Its potential significance in cancer warrants further investigation, given the altered and highly adaptable metabolism of tumor cells. It has been reported that both high and low levels of TXNDC5 expression are associated with multiple diseases, such as arthritis, cancer, diabetes, brain diseases, and infections, as well as worse prognoses. TXNDC5 has been attributed to both oncogenic and tumor-suppressive features. It has been concluded that in cancer, TXNDC5 acts as a foe and responds to metabolic and cellular stress signals to promote the survival of tumor cells against apoptosis. Conversely, in normal cells, TXNDC5 acts as a friend to safeguard cells against oxidative and endoplasmic reticulum stress. Therefore, TXNDC5 could serve as a viable biomarker or even a potential pharmacological target.

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Section: Txndc5 and Kidney Cancermentioning

confidence: 85%

Thioredoxin Domain Containing 5 (TXNDC5): Friend or Foe?

Bidooki,

Navarro,

Fernandes

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

“…73 PDIs also exhibit anti-aggregation activity against a broad range of unfolded client proteins. [74][75][76] PDIs thus play a key role in maintaining protein homeostasis by not only mediating protein folding via catalysis of disulde bond formation, reduction, and rearrangement but also by chaperoning aggregation-prone clients to decrease the risk of ER stress. Notably, many studies have reported that PDIs play important roles in protein misfolding-related pathologies such as ALS, Alzheimer's disease (AD), Parkinson's disease (PD), and type II diabetes.…”

Section: Functional Importance Of Oligomerization Of Molecular Chaper...mentioning

confidence: 99%