A comprehensive strategy integrating metabolomics with multiple chemometric for discovery of function related active markers for assessment of foodstuffs: A case of hawthorn (Crataegus cuneata) fruits

Yan, Chunze; Du, Kunze; Hou, Shixin; Yang, Rui; Qi, Lina; Li, Jin; Chang, Yan‐xu

doi:10.1016/j.foodchem.2022.132464

Cited by 17 publications

(6 citation statements)

References 25 publications

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“…In addition, research suggests that the ancient trans-Beringian migrations made the species of East Asia and western North America closely related (Phipps, 1983;. Our results are consistent with this study (Cui et al, 2022;Liu et al, 2017;Lou et al, 2022). However, it has been found that the concentration of vitexin derivatives in the leaves of European hawthorn was significantly higher than that of North American hawthorn, while the rutin content of North American hawthorn was significantly higher than European hawthorn (Lund et al, 2020).…”

Section: Phylogenomic Validationsupporting

confidence: 91%

“…It is worth noting that most species in clade B are used as cultivated varieties and medicinal materials, and it is generally believed that hawthorn in clade B may have more value. Most of the current studies have focused on species associated with clade B, while fewer studies have been conducted on species associated with clade A ( Cui et al, 2022 ; Liu et al, 2017 ; Lou et al, 2022 ). However, it has been found that the concentration of vitexin derivatives in the leaves of European hawthorn was significantly higher than that of North American hawthorn, while the rutin content of North American hawthorn was significantly higher than European hawthorn ( Lund et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

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Comparative Genomic and Phylogenetic Analysis of Chloroplast Genomes of Hawthorn (Crataegus spp.) in Southwest China

Luo

Zhang

et al. 2022

Front. Genet.

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The hawthorns (Crataegus spp.) are widely distributed and famous for their edible and medicinal values. There are ∼18 species and seven varieties of hawthorn in China distributed throughout the country. We now report the chloroplast genome sequences from C. scabrifolia, C. chungtienensis and C. oresbia, from the southwest of China and compare them with the previously released six species in Crataegus and four species in Rosaceae. The chloroplast genome structure of Crataegus is typical and can be divided into four parts. The genome sizes are between 159,654 and 159,898bp. The three newly sequenced chloroplast genomes encode 132 genes, including 85 protein-coding genes, 37 tRNA genes, and eight rRNA genes. Comparative analysis of the chloroplast genomes revealed six divergent hotspot regions, including ndhA, rps16-trnQ-UUG, ndhF-rpl32, rps16-psbK, trnR-UCU-atpA and rpl32-trnL-UAG. According to the correlation and co-occurrence analysis of repeats with indels and SNPs, the relationship between them cannot be ignored. The phylogenetic tree constructed based on the complete chloroplast genome and intergenic region sequences indicated that C. scabrifolia has a different origin from C. chungtienensis and C. oresbia. We support the placement of C. hupehensis, C. cuneata, C. scabrifolia in C. subg. Crataegus and C. kansuensis, C. oresbia, C. kansuensis in C. subg. Sanguineae. In addition, based on the morphology, geographic distribution and phylogenetic relationships of C. chungtienensis and C. oresbia, we speculate that these two species may be the same species. In conclusion, this study has enriched the chloroplast genome resources of Crataegus and provided valuable information for the phylogeny and species identification of this genus.

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Section: Phylogenomic Validationsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparative Genomic and Phylogenetic Analysis of Chloroplast Genomes of Hawthorn (Crataegus spp.) in Southwest China

Luo

Zhang

et al. 2022

Front. Genet.

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“… 2021 ); Crataegus cuneata NC 058896.1 (Cui et al. 2022 ); Crataegus pinnatifida var. major MW653326.1 (Pang et al.…”

Section: Resultsmentioning

confidence: 99%

The complete chloroplast genome of Crataegus scabrifolia (Franch.) Rehd (Rosaceae), a medicinal and edible plant in Southwest China

Tian

Zhao

2023

Mitochondrial DNA Part B

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Crataegus scabrifolia (Franch.) Rehd is a medicinal and edible plant in Southwest China. The chloroplast genome of C. scabrifolia was analyzed by high-throughput sequencing technology, and its genetic relationship to related species was discussed. The chloroplast genome is 159,637 bp long, with two inverted repeat (IR) regions (26,384 bp each) that separate a large single-copy (LSC) region (87,730 bp) and a small single-copy (SSC) region (19,139 bp). A total of 127 genes were annotated, including 83 protein-coding genes, 8 rRNA genes, and 36 tRNA genes. The phylogenetic tree shows that C. hupehensis is closely related to C. scabrifolia with strong bootstrap support.

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“…Quercetin is the strongest known anti-inflammatory flavonoid. In addition, quercetin is contained in the ingredients of many herbal medicines that feature in Kampo, such as Japanese hawthorn (Crataegus cuneata) [52]. Furthermore, onions are rich in rutin, which is a glycoside form of quercetin [20].…”

Section: Onionsmentioning

confidence: 99%

Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases

Santa

Watanabe

Kumazawa

et al. 2023

IJMS

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A variety of phytocompounds contained in medical plants have been used as medication, including Kampo (traditional Japanese) medicine. Phytochemicals are one category of the chemical compounds mainly known as antioxidants, and recently, their anti-inflammatory effects in preventing chronic inflammation have received much attention. Here, we present a narrative review of the health-promotion and disease-prevention effects of phytochemicals, including polyphenols, the latter of which are abundant in onions, oranges, tea, soybeans, turmeric, cacao, and grapes, along with the synergetic effects of vitamin D. A phenomenon currently gaining popularity in Japan is finding non-disease conditions, so-called ME-BYO (mibyou) and treating them before they develop into illnesses. In addition to lifestyle-related diseases such as metabolic syndrome and obesity, dementia and frailty, commonly found in the elderly, are included as underlying conditions. These conditions are typically induced by chronic inflammation and might result in multiple organ failure or cancer if left untreated. Maintaining gut microbiota is important for suppressing (recently increasing) intestinal disorders and for upregulating immunity. During the COVID-19 pandemic, the interest in phytochemicals and vitamin D for disease prevention increased, as viral and bacterial infection to the lung causes fatal inflammation, and chronic inflammation induces pulmonary fibrosis. Furthermore, sepsis is a disorder inducing severe organ failure by the infection of microbes, with a high mortality ratio in non-coronary ICUs. However, antimicrobial peptides (AMPs) working using natural immunity suppress sepsis at the early stage. The intake of phytochemicals and vitamin D enhances anti-inflammatory effects, upregulates immunity, and reduces the risk of chronic disorders by means of keeping healthy gut microbiota. Evidence acquired during the COVID-19 pandemic revealed that daily improvement and prevention of underlying conditions, in terms of lifestyle-related diseases, is very important because they increase the risk of infectious diseases. This narrative review discusses the importance of the intake of phytochemicals and vitamin D for a healthy lifestyle and the prevention of ME-BYO, non-disease conditions.

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A comprehensive strategy integrating metabolomics with multiple chemometric for discovery of function related active markers for assessment of foodstuffs: A case of hawthorn (Crataegus cuneata) fruits

Cited by 17 publications

References 25 publications

Comparative Genomic and Phylogenetic Analysis of Chloroplast Genomes of Hawthorn (Crataegus spp.) in Southwest China

Comparative Genomic and Phylogenetic Analysis of Chloroplast Genomes of Hawthorn (Crataegus spp.) in Southwest China

The complete chloroplast genome of Crataegus scabrifolia (Franch.) Rehd (Rosaceae), a medicinal and edible plant in Southwest China

Phytochemicals and Vitamin D for a Healthy Life and Prevention of Diseases

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