“…The fraction of nanoparticulate Ag in relation to the total migrated Ag ranged from below 1% to 69% (Echegoyen & Nerín 2013;von Goetz et al 2013;Ramos et al 2016). Several studies on AgNP-containing polymers did not examine if the observed migration of Ag was due to migration of AgNPs (e.g., Busolo et al 2010;Emamifar et al 2010;Song et al 2011;Bott et al 2014b;Jokar & Abdul Rahman 2014). Only one experimental study that applied a method to detect ENOs (transmission electron microscopy -TEM) described the absence of AgNPs in migrates from AgNP-containing polymer (Ntim et al 2015).…”
Section: Open Question 1: Can Enos Migrate From Fcms At All?mentioning
confidence: 99%
“…Desorption could also be responsible for a release of ENOs from the cut edges of the samples during migration testing. The so-called 'cutting edge effect' should be considered as more severe testing, and was discussed to generate unrealistic contact conditions compared with conventional use (Bott et al 2014b).…”
Section: Open Question 2: If Migration Of Enos Occurs What Is the MImentioning
confidence: 99%
“…However, additional factors, like mechanical forces (abrasion, vibration), microwave treatment, heating and UV exposure, will have to be considered as they can have a large influence on the release and occur in the 'real-life' use of FCMs. As described above, the 'cutting-edge effect' was discussed to generate unrealistic contact conditions (Bott et al 2014b). This will be especially true if desorption of ENOs from the surface instead of diffusion were the dominating mechanism.…”
Section: Open Question 2: If Migration Of Enos Occurs What Is the MImentioning
confidence: 99%
“…for an initial concentration of carbon black in LDPE of 25,000 mg kg -1 (Bott et al 2014b). In another study by the same authors, the migration of TiN nanoparticles from LDPE (initial concentration 1000 mg kg -1 ) was predicted to be 30.7-1.38 × 10 -18 mg kg -1 after 10 days at 40°C for diameters of 1-10 nm, respectively.…”
Section: Open Question 2: If Migration Of Enos Occurs What Is the MImentioning
The use of nanomaterials in food-contact applications has created enormous interest in recent years. The potential migration of engineered nano-objects (ENOs) from food-contact materials (FCMs) is one of the most important concerns regarding potential human exposure to ENOs and health risks. Current research focusing on FCMs has often reached inconsistency regarding migration of ENOs. The scope of this critical review is to give a concise overview of the most relevant aspects of the subject, and to identify and discuss the major open questions in relation to migration of ENOs from FCMs. This includes the very fundamental questions whether ENOs can migrate from FCMs at all and what the potential release mechanisms of ENOs could be. The inconsistency of findings from experimental studies is highlighted based on the example of silver nanoparticle migration from polymer-based FCMs. Challenges in the detection and characterisation of ENOs in migration studies and the suitability of the most frequently used analytical techniques are discussed. Further, this review questions the suitability of standard food simulants and migration test conditions for FCMs as well as of conventional mathematical migration models. Considerations regarding the risk for consumers associated with migrating ENOs from FCMs are discussed.
ARTICLE HISTORY
“…The fraction of nanoparticulate Ag in relation to the total migrated Ag ranged from below 1% to 69% (Echegoyen & Nerín 2013;von Goetz et al 2013;Ramos et al 2016). Several studies on AgNP-containing polymers did not examine if the observed migration of Ag was due to migration of AgNPs (e.g., Busolo et al 2010;Emamifar et al 2010;Song et al 2011;Bott et al 2014b;Jokar & Abdul Rahman 2014). Only one experimental study that applied a method to detect ENOs (transmission electron microscopy -TEM) described the absence of AgNPs in migrates from AgNP-containing polymer (Ntim et al 2015).…”
Section: Open Question 1: Can Enos Migrate From Fcms At All?mentioning
confidence: 99%
“…Desorption could also be responsible for a release of ENOs from the cut edges of the samples during migration testing. The so-called 'cutting edge effect' should be considered as more severe testing, and was discussed to generate unrealistic contact conditions compared with conventional use (Bott et al 2014b).…”
Section: Open Question 2: If Migration Of Enos Occurs What Is the MImentioning
confidence: 99%
“…However, additional factors, like mechanical forces (abrasion, vibration), microwave treatment, heating and UV exposure, will have to be considered as they can have a large influence on the release and occur in the 'real-life' use of FCMs. As described above, the 'cutting-edge effect' was discussed to generate unrealistic contact conditions (Bott et al 2014b). This will be especially true if desorption of ENOs from the surface instead of diffusion were the dominating mechanism.…”
Section: Open Question 2: If Migration Of Enos Occurs What Is the MImentioning
confidence: 99%
“…for an initial concentration of carbon black in LDPE of 25,000 mg kg -1 (Bott et al 2014b). In another study by the same authors, the migration of TiN nanoparticles from LDPE (initial concentration 1000 mg kg -1 ) was predicted to be 30.7-1.38 × 10 -18 mg kg -1 after 10 days at 40°C for diameters of 1-10 nm, respectively.…”
Section: Open Question 2: If Migration Of Enos Occurs What Is the MImentioning
The use of nanomaterials in food-contact applications has created enormous interest in recent years. The potential migration of engineered nano-objects (ENOs) from food-contact materials (FCMs) is one of the most important concerns regarding potential human exposure to ENOs and health risks. Current research focusing on FCMs has often reached inconsistency regarding migration of ENOs. The scope of this critical review is to give a concise overview of the most relevant aspects of the subject, and to identify and discuss the major open questions in relation to migration of ENOs from FCMs. This includes the very fundamental questions whether ENOs can migrate from FCMs at all and what the potential release mechanisms of ENOs could be. The inconsistency of findings from experimental studies is highlighted based on the example of silver nanoparticle migration from polymer-based FCMs. Challenges in the detection and characterisation of ENOs in migration studies and the suitability of the most frequently used analytical techniques are discussed. Further, this review questions the suitability of standard food simulants and migration test conditions for FCMs as well as of conventional mathematical migration models. Considerations regarding the risk for consumers associated with migrating ENOs from FCMs are discussed.
ARTICLE HISTORY
“…The estimated migration was 1 x10 -6 mg/kg food. Real migration, if any, is expected to be even lower and therefore consumer exposure would be very low, if any (Bott et al, 2014).…”
This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids deals with the safety assessment of the additives (butadiene, ethyl acrylate, methyl methacrylate, styrene)
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