A comprehensive study on Plantago ovata/PVA biocompatible nanofibers: Fabrication, characterization, and biological assessment

Abstract

In this study, a biocompatible nanofiber is fabricated using Plantago ovata mucilage (POM) combined with polyvinyl alcohol (PVA), which is considered as a non‐toxic polymer. High quality nanofibers were produced by controlling the electrospinning parameters after selecting an appropriate solvent for the POM/PVA combination (12% PVA and 3% POM). Electrospinning parameters, including high voltage, distance from collector to tip, feed rate and POM to PVA proportion were optimized following preparation of an aqueous POM/PVA solution. Using the results of scanning electron microscopy, the optimized electrospinning conditions for producing POM/PVA nanofibers were determined (high voltage = 18 kV, distance = 15 cm, feed rate = 0.125 ml/hr, PMM/PVA = 50/50) and uniform nanofibers with an average diameter of 250 nm were produced. The POM/PVA nanofiber sample was evaluated by determining the mechanical strength, characterization of produced nanofiber morphology, and investigating the cell viability by applying MTT assay. The bands for both POM and PVA from FTIR results showed that the samples remained stable. The tensile strength results showed that blending POM with PVA solution enhanced the Young's modulus by factor of 3.2 (0.2 MPa to 0.64 MPa). The MTT analysis on POM/PVA cell lines proved that the produced nanofiber considerably enabled the cellular proliferation. Enhancement in these analysis indicated how POM‐based nanofibers is a promising scaffold for cell culture, drug delivery systems and food additives.

Lyophilized Nasal Inserts of Atomoxetine HCl Solid Lipid Nanoparticles for Brain Targeting as a Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD): A Pharmacokinetics Study on Rats

“…Phosphate buffer (PH = 5.5) was obtained by mixing 94.6 mL of solution (A) and 3.6 mL of solution (B) [ 51 , 52 ]. Moreover, atomoxetine HCl 20.56 mg (equivalent to 18 mg of Atomoxetine base) and pluronic F127 were dissolved in 1 mL of phosphate buffer (PH = 5.5) containing (1% w / v ) PVA that was previously prepared by mixing 1 g of PVA with 100 mL of phosphate buffer (PH = 5.5) and stirred for 2 h on a magnetic stirrer at 70 °C [ 53 ]. Subsequently, in a 100 mL glass beaker the lipid phase composed of stearic acid or compritol 888 ATO and span 60 were heated to 85 °C with moderate mixing by using a high-speed magnetic stirrer.…”

Plantago media L.—Explored and Potential Applications of an Underutilized Plant

“…could also find application in other important areas, such as scaffolds for cell culture, drug delivery systems or food additives. This would involve the development of biocompatible materials, such as those proposed by Allafchian et al [ 103 ], based on P. ovata mucilage and polyvinyl alcohol.…”

Production and characterization of biocompatible nanofibrous scaffolds made of β-sitosterol loaded polyvinyl alcohol/tragacanth gum composites

“…Electrospinning is a process that uses a millimeter-scale nozzle to create a polymer fiber stream or jet. By creating an electrostatic field under which a conductive capillary is attached to a reservoir containing a polymeric solution and a conductive collective screen [16]. This method allows one to better connect the cathodic side of a polarized electrode to a reservoir [17].…”