A comprehensive study on the synthesis and paramagnetic properties of PEG-coated Fe3O4 nanoparticles

Yang, Jing; Zou, Ping; Yang, Lili; Cao, Jianliang; Sun, Yunfei; Han, Donglai; Yang, Shuo; Wang, Zhe; Chen, Gang; Wang, Bingji; Kong, Xiangwang

doi:10.1016/j.apsusc.2014.03.018

Cited by 95 publications

(37 citation statements)

References 34 publications

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“…The Fe 3 O 4 nanoparticles (NPs) were prepared by the modified coprecipitation method (Yang et al 2014 …”

Section: Preparation Of Fe 3 O 4 Nanoparticlesmentioning

confidence: 99%

“…Furthermore, magnetic Fe 3 O 4 nanoparticles are superparamagnetic with a large surface area, which reduces the mass transfer resistance in traditional immobilization processes (Wang et al 2007). Such magnetic materials are widely used in various fields, such as drug delivery and biosensing, environmental remediation, and ferrofluid-based processes (Wang et al 2007(Wang et al , 2009Yang et al 2014). However, using magnetic nanoparticle-immobilized cells to produce reuterin has rarely been reported.…”

Section: Introductionmentioning

confidence: 98%

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Efficient production of reuterin from glycerol by magnetically immobilized Lactobacillus reuteri

Liu

2015

Appl Microbiol Biotechnol

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Reuterin is a compound that contains the monomeric, hydrated monomeric, and cyclic dimeric forms of 3-hydroxypropionaldehyde (3-HPA). It is widely used as a food preservative due to its antimicrobial properties, and 3-HPA is also an important precursor for several industrial chemicals. In this study, we first developed an efficient immobilization process involving magnetic cell entrapment for production of reuterin from glycerol by Lactobacillus reuteri. The cell growth condition was optimized by statistical approaches. High conversion efficiency was achieved using k-carrageenan as the immobilization support and Fe3O4 as magnetic nanoparticles. Furthermore, addition of 0.02 g/L vitamin B12, 10 mmol/L Mg(2+), and glucose in a molar ratio of 0.15 to glycerol significantly increased the conversion rate. Under optimal conditions, 235.9 mmol/L 3-HPA was produced from 250 mmol/L initial glycerol in 1.5 h, with a molar yield of 94.4 % and a productivity of 15.4 mmol/(g dry cell weight∙L∙h), which were the highest values to date. Thus, this study demonstrated a promising process for the improvement of biocatalyst efficiency in biotransformation.

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“…The Fe 3 O 4 nanoparticles (NPs) were prepared by the modified coprecipitation method (Yang et al 2014 …”

Section: Preparation Of Fe 3 O 4 Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Efficient production of reuterin from glycerol by magnetically immobilized Lactobacillus reuteri

Liu

2015

Appl Microbiol Biotechnol

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“…Fe 3 O 4 nanoparticle-based drug delivery systems, specifically, have shown high degree of efficiency in cancer therapy [11][12][13], because Fe 3 O 4 nanoparticles with the proper structures, sizes, and surface properties would readily accumulate and retain in solid tumors. [14][15][16][17] However, an important disadvantage of Fe 3 O 4 particles for drug delivery systems is that they are rapidly cleared by macrophages or the reticuloendothelial system (RES) before they are able to reach the site of the tumor cells. [18,19] Thus, it is important to modify the surface of Fe 3 O 4 nanoparticles so as to make them have biocompatibility and specific functionalized groups on the surface to enable conjugation of the drug.…”

Section: Introductionmentioning

confidence: 99%

Magnetic targeted drug delivery carriers encapsulated with pH-sensitive polymer: synthesis, characterization and in vitro doxorubicin release studies

Shen

Jiang

et al. 2016

Journal of Biomaterials Science, Polymer Edition

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Targeted and efficient delivery of drug to tumor is one of the crucial issues in cancer therapy. In this work, we have successfully designed and prepared the pH-sensitive magnetic nanoparticles (MNPs) as targeted anticancer drug carriers, in which the MNPs were coated by poly(acrylic acid) (PAA) and the obtained PAA@MNPs exhibited a size within 100 nm, good stability, and superparamagnetic responsibility (Ms 45.97 emu/g). Doxorubicin (DOX) can be successfully loaded onto MNPs via electrostatic interaction, and the drug loading content and loading efficiency are 26.4 and 88.1%, respectively. Moreover, the release studies showed that the drug-loaded carriers (MNPs-DOX) had excellent pH sensitivity, 75.6% of the loaded DOX was released at pH 4.0 within 48 h. Importantly, MTT assays in HUVEC and MCF-7 cells demonstrated that MNPs-DOX exhibited high anti-tumor activity, while the PAA@MNPs were practically nontoxic. Thus, our results revealed that PAA@MNPs would be a competitive candidate for biomedical application and MNPs-DOX could be used in targeted cancer therapy.

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“…One of the most important and rapidly growing fields is the use of the SPIONs as contrast agents for MRI [4][5][6]. Coating the SPIONs with various surface stabilizing agents containing long-chain hydrocarbons helps to prevent the aggregation of particles in biological solution for more effective stabilization [7][8][9], and makes them hardly recognized by the macrophage-monocytic system [10].…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles coated with different polymers and their MRI contrast effects in the mouse brains

Xie

Zhang

Wang

et al. 2015

Applied Surface Science

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A comprehensive study on the synthesis and paramagnetic properties of PEG-coated Fe3O4 nanoparticles

Cited by 95 publications

References 34 publications

Efficient production of reuterin from glycerol by magnetically immobilized Lactobacillus reuteri

Efficient production of reuterin from glycerol by magnetically immobilized Lactobacillus reuteri

Magnetic targeted drug delivery carriers encapsulated with pH-sensitive polymer: synthesis, characterization and in vitro doxorubicin release studies

Superparamagnetic iron oxide nanoparticles coated with different polymers and their MRI contrast effects in the mouse brains

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