A comprehensive summary of disease variants implicated in metal allergy

Roach, Ka; Roberts, Jr

doi:10.1080/10937404.2022.2104981

Cited by 14 publications

(9 citation statements)

References 541 publications

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“…These abnormal inflammatory responses may be significant risk factors for the development of autoimmune diseases. Although the detailed mechanisms are still uncertain, there is a substantial body of literature on the role of metal sensitization in contributing to the onset, progression, and severity of symptoms in these diseases (e.g., RA, chronic fatigue syndrome, and dryness) 28 . We anticipate further literature to help clarify the association between metal implants and disease.…”

Section: Discussionmentioning

confidence: 99%

“…However, recent investigations have illuminated the interactive nexus between implants and autoimmune diseases. Research indicates an association between breast implants and an increased risk of RA 24 , 25 , with analogous effects potentially extending to metal implants 26 - 28 . Metal implants may instigate autoimmune disorders, and individuals with autoimmune disorders may experience more frequent allergic reactions to metal implants 29 , which, in turn, could contribute to the progression of connective tissue disorders 29 .…”

Section: Introductionmentioning

confidence: 99%

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Increased Risk of New-Onset Rheumatoid Arthritis Among Osteoarthritis Patients Received Total Knee Arthroplasty: a global federated health network analysis

Lin,

Chang,

et al. 2024

Int. J. Med. Sci.

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Background: Complications of total knee arthroplasty (TKA) had been widely discussed. However, whether TKA influence risk of rheumatoid arthritis (RA) in osteoarthritis patients remained uncertain. We intend to evaluate the risk of RA in osteoarthritis patients underwent TKA. Methods: In this retrospective cohort study, data was retrieved from the US collaborative networks in TriNetX research network. Within the study period between 2005 and 2017, osteoarthritis patients underwent TKA were enrolled as case cohort whereas osteoarthritis patients never underwent TKA were enrolled as control cohort. Covariates were matched via propensity score matching. Risk of RA in TKA patients were valuated under various follow-up time and sensitivity models. Results: Under 1-year, 3-year and 5-year of follow-up, TKA patients were associated with significantly elevated risk of RA, especially under 1-year follow-up (HR=1.74; 95% CI, 1.39-2.18). Subgroup analysis demonstrated a significant increase in the risk of RA following TKA in the female subgroup (HR=1.42; 95% CI, 1.24-1.63), the subgroup aged 18-64 years (HR=1.48; 95% CI, 1.11-1.97), and the subgroup aged greater than 65 years old (HR=1.38; 95% CI, 1.21-1.58) based on 5-year follow-up. Conclusion: Clinicians should be concerned about uncharted association between TKA and RA reported our current study. Additional prospective studies and in-depth mechanistic inquiries were warranted to determine the causation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased Risk of New-Onset Rheumatoid Arthritis Among Osteoarthritis Patients Received Total Knee Arthroplasty: a global federated health network analysis

Lin,

Chang,

et al. 2024

Int. J. Med. Sci.

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“…It is frequently caused by fragrant cosmetics, with stabilizing and texture agents being the two most significant allergens found in these products [ 2 , 3 , 4 , 5 ]. Additional triggers include a variety of workplace and lifestyle items like metals, detergents, rubber gloves, jewelry, and dyes [ 6 , 7 , 8 ]. CHS is a common cause of allergic contact dermatitis (ACD), a skin condition which manifests in patients as itching, burning pain, and general discomfort mediated by an antigen-specific T-cell response [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Berry Extracts and Their Bioactive Compounds Mitigate LPS and DNFB-Mediated Dendritic Cell Activation and Induction of Antigen Specific T-Cell Effector Responses

Upadhaya,

Lamenza,

Shrestha

et al. 2023

Antioxidants

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Berries have gained widespread recognition for their abundant natural antioxidant, anti-inflammatory, and immunomodulatory properties. However, there has been limited research conducted thus far to investigate the role of the active constituents of berries in alleviating contact hypersensitivity (CHS), the most prevalent occupational dermatological disease. Our study involved an ex vivo investigation aimed at evaluating the impact of black raspberry extract (BRB-E) and various natural compounds found in berries, such as protocatechuic acid (PCA), proanthocyanidins (PANT), ellagic acid (EA), and kaempferol (KMP), on mitigating the pathogenicity of CHS. We examined the efficacy of these natural compounds on the activation of dendritic cells (DCs) triggered by 2,4-dinitrofluorobenzene (DNFB) and lipopolysaccharide (LPS). Specifically, we measured the expression of activation markers CD40, CD80, CD83, and CD86 and the production of proinflammatory cytokines, including Interleukin (IL)-12, IL-6, TNF-α, and IL-10, to gain further insights. Potential mechanisms through which these phytochemicals could alleviate CHS were also investigated by investigating the role of phospho-ERK. Subsequently, DCs were co-cultured with T-cells specific to the OVA323-339 peptide to examine the specific T-cell effector responses resulting from these interactions. Our findings demonstrated that BRB-E, PCA, PANT, and EA, but not KMP, inhibited phosphorylation of ERK in LPS-activated DCs. At higher doses, EA significantly reduced expression of all the activation markers studied in DNFB- and LPS-stimulated DCs. All compounds tested reduced the level of IL-6 in DNFB-stimulated DCs in Flt3L as well as in GM-CSF-derived DCs. However, levels of IL-12 were reduced by all the tested compounds in LPS-stimulated Flt3L-derived BMDCs. PCA, PANT, EA, and KMP inhibited the activated DC-mediated Interferon (IFN)-γ and IL-17 production by T-cells. Interestingly, PANT, EA, and KMP significantly reduced T-cell proliferation and the associated IL-2 production. Our study provides evidence for differential effects of berry extracts and natural compounds on DNFB and LPS-activated DCs revealing potential novel approaches for mitigating CHS.

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“…Metal allergies have been a growing concern in the general population over the past several decades [ 1 ]. These are most commonly associated with nickel, chromium, cobalt, and titanium, which are often found in jewelry, coins, implant clips or devices, and dental materials.…”

Section: Introductionmentioning

confidence: 99%

“…During these procedures, surgical clips made from common metals such as nickel or titanium are often used to clamp the arteries and ducts. This is where a problem can present itself [ 1 , 2 ]. Diverse metals are known to elicit an allergic reaction, yet nickel is the most recurring cause of metal allergy [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Rare Metallic Allergy Reaction Presentation to Cholecystectomy Surgical Clip

Mozafari¹,

Santos²,

Ohri³

et al. 2022

Cureus

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Metal allergies have been a growing concern in the general population over the past several decades. Laparoscopic cholecystectomy is the standard treatment for gallbladder diseases such as cholelithiasis and cholecystitis, during which surgical clips composed of metals such as nickel or titanium are often used to clamp the arteries and ducts. These metals are documented to produce hypersensitivity reactions. Here, we present the case of a 53-year-old male patient who successfully underwent laparoscopic cholecystectomy and two weeks later reported constant right upper quadrant pain accompanied by nausea that was exacerbated by exercise and food. After several months of severe interference with the patient's lifestyle, we removed the surgical clips after ruling out all possible organic causes of the pain. A total of six surgical clips were removed during surgery, and the patient reported a substantial resolution of symptoms post-operation. Post-cholecystectomy syndrome (PCS), allergy to the metallic surgical clips, and migration or improper clip placement during surgery were all considered possible causes for the pain. Still, the clinical presentation and laboratory studies pulled focus toward metallic surgical clip allergy as the most plausible cause for the presenting symptoms. The metallic haptens released by the surgical clips activate the innate and adaptive immune response cascades and pre-sensitize the CD8 and B cells to the metallic allergens. With reexposure, these pre-sensitized CD8 and B cells trigger a hypersensitivity reaction. Standardizing allergy tests as part of the pre-operation checklist can prove to be an inexpensive way to eliminate such post-surgical complications. Furthermore, alternatives like absorbable sutures or even different hypoallergenic metal or plastic clips can be considered viable options to replace nickel or titanium-made surgical clips during surgery.

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A comprehensive summary of disease variants implicated in metal allergy

Cited by 14 publications

References 541 publications

Increased Risk of New-Onset Rheumatoid Arthritis Among Osteoarthritis Patients Received Total Knee Arthroplasty: a global federated health network analysis

Increased Risk of New-Onset Rheumatoid Arthritis Among Osteoarthritis Patients Received Total Knee Arthroplasty: a global federated health network analysis

Berry Extracts and Their Bioactive Compounds Mitigate LPS and DNFB-Mediated Dendritic Cell Activation and Induction of Antigen Specific T-Cell Effector Responses

Rare Metallic Allergy Reaction Presentation to Cholecystectomy Surgical Clip

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