A comprehensive survey on investigation techniques of exhaled breath (EB) for diagnosis of diseases in human body

Mule, Nilakshi Maruti; Patil, Dipti D.; Kaur, Mandeep

doi:10.1016/j.imu.2021.100715

Cited by 47 publications

(32 citation statements)

References 86 publications

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“…The bad habit of cigarette smoking plays a leading role in the occurrence of COPD. The disease is initially underdiagnosed, and it is a life-threatening disease [ 1 ]. Once the damage is done to lungs, then it is irreversible.…”

Section: Introductionmentioning

confidence: 99%

Analyzing the Treatment of Patients with Acute Exacerbation of COPD with the Aid of Intelligent Diagnosis Method

Jiang

Zhao

Song

et al. 2022

Journal of Healthcare Engineering

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To observe the clinical efficacy of heat clearing phlegm mixture combined with vibration sputum excretion instrument in the treatment of patients with acute exacerbation of COPD with phlegm-heat obstructing lung, 90 patients with acute exacerbation of COPD are selected and divided into three groups, namely, control group, traditional medicine group, and combined group: the control group (conventional western medicine treatment), traditional medicine group (heat clearing and phlegm mixture), and combined group (heat clearing and phlegm mixture + vibratory sputum excretion instrument) with 30 cases each. All the patients in the three groups were given conventional western medicine treatment. On this basis, the traditional medicine group was given the oral administration of the heat-clearing and phlegm-clearing mixture, and the combined group was given the oral administration of the heat-clearing and phlegm-clearing mixture and the vibratory sputum discharge apparatus. Machine learning is used to classify the patients into three groups based on the characteristics of their biomarkers, physical attributes, and medical history. The TCM syndrome score, blood gas analysis, lung function, and inflammatory indexes of the three groups were compared. TCM syndrome scores of the three groups were all lower than before; both the combined group and the TCM group were better than the control group ( P < 0.05). Although the improvement degree of the combined group was better than that of the TCM group, the difference was not statistically significant ( P > 0.05). TCM syndrome effect is seen to be 96.55% in the combined group, 89.29% in the TCM group, and 63.33% in the control group. Blood gas analysis is also performed; PO2 and PCO2 of the three groups were significantly improved after treatment. The combination group was superior to the traditional medicine group and the control group ( P < 0.05), and the traditional medicine group was superior to the control group ( P < 0.05). It is concluded that the combination of heat clearing phlegm mixture and vibration sputum excretion instrument can improve TCM syndrome score, CAT score, blood gas analysis, lung function, and inflammatory indicators in patients with acute exacerbation of COPD with phlegm-heat obstructing lung.

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Section: Introductionmentioning

confidence: 99%

Analyzing the Treatment of Patients with Acute Exacerbation of COPD with the Aid of Intelligent Diagnosis Method

Jiang

Zhao

Song

et al. 2022

Journal of Healthcare Engineering

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“…A potential peer group study of Women's Health Study participants [ 23 ] looked at the impact of different lifestyle elements on the risk of stroke in females and found a weak correlation between the risk of stroke and physical fitness alone. The literature reveals that combining routine exercise with smoking cessation, a low body mass index (BMI), a nutritious diet, and consuming alcohol in lower quantities was associated with a lower risk of stroke [ 8 , 24 , 25 ]. As many of the trials excluded females, there is less data on the function of exercise in improving the outcomes in females to make judgments and provide guidelines.…”

Section: Introductionmentioning

confidence: 99%

Walking and Activeness: The First Step toward the Prevention of Strokes and Mental Illness

Chuo

2022

Computational Intelligence and Neuroscience

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Physical activity, especially routine walking, is an imperative factor for the prevention of strokes, mental illness, and cardiovascular diseases (CVDs). The NIH (National Institute of Health) has also acknowledged walking as the most important factor of the stroke rehabilitation program. Many research studies are presented by physicians and researchers in the literature that highlight the positive impacts of walking on human health (physical and mental). This paper has the objective of studying the impact of regular walking, especially on mental illness, CVDs, and strokes. The C-reactive protein (CRP), P-selectin protein, and homocysteine biomarkers are considered to decide the improvement in the health of an individual with respect to CVDs and strokes. The other parameters considered for the recommendations of physicians and healthcare experts for mental health are PSS (perceived stress score) and ESS (Epworth sleepiness score) that control mental illness. The values are measured for the participating subjects before participating in the walking activity and after the end of the walking schedule to see the impact on individuals. The overall mental and physical health of an individual contributes to the chances of occurrence of CVDs, mental illness, and strokes in individuals aged between 40 years and 55 years, as per the study presented in this paper. The results show that the PSS and ESS scores are improved after the walking activity. Eventually, it improved recovery from many kinds of mental illness and also reduced the chances of strokes. Similarly, the levels of the biomarkers that determine the chances of an individual having CVD or stroke also improved. Walking can impact our overall health in many ways, however, in this paper, the focus is given to ailments, such as strokes, CVDs, and mental illness. The results show that stress and improper sleepiness can impact mental health negatively. The research outcome is measured by adding walking in a routine life so that every individual can get rid of many physical and mental ailments. The results presented in the paper reveal that the 90-day walking program has created a good impact on the health of individuals by improving their physical and mental health.

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“…It is inevitable to accurately identify the stage of the patients who are suffering from lung cancer as this eventually contributes to better prognosis and treatment options. Many techniques have been developed till date for the diagnosis of lung cancer at early stages or to describe the effective or current stage of the lung cancer with good accuracy [ 3 , 4 ]. Lung cancer (LC) is the utmost communal malignant tumour that has affected the entire world badly in the current era, as per the global cancer statistics report.…”

Section: Introductionmentioning

confidence: 99%

Impact of HSP90α, CEA, NSE, SCC, and CYFRA21-1 on Lung Cancer Patients

Zhou

Yang

Wang

et al. 2021

Journal of Healthcare Engineering

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Lung cancer is a lethal disease, and early diagnosis with the aid of biomarkers such as HSP90α protein can certainly assist the doctors to start treatment of patient at the earliest and can save their lives. To analyse the diagnostic value of HSP90α expression in lung cancer patients by collecting data of patients through IoT devices to avoid delay in treatments, a study has been presented in this paper where the significance of HSP90α biomarker is highlighted in early diagnosis of patients suffering from lung cancer. The second objective of the research study is to examine the correlation between the appearance level of HSP90α biomarker and the clinicopathological features of lung cancer. It is also evaluated whether the changes in HSP90α index are indicative or noteworthy before and after surgery of lung cancer patients. An observatory study of 78 patients with lung cancer in Qinhuangdao Hospital is presented in this paper where the samples were collected from June 2018 to March 2020. Their data were collected through IoT devices used in the latest healthcare facilities of the hospital. The ELISA method was utilized to identify the level of plasma HSP90 and to analyse HSP90 levels between the lung cancer group and healthy group of people. The relationship between HSP90 and the clinical pathological features of 78 patients suffering from lung cancer was analysed. An electrochemical luminescence method was used to detect CEA, NSE, SCC, and CYFRA21-1 levels. ROC curve and box plots were used to determine the analytic value of HSP90 and other biomarkers used in lung cancer diagnosis. Forty-two patients with moderate to early stage lung cancer with surgical correction were selected, and paired sample T test was used to analyse HSP90 levels before and after surgery. The plasma HSP90 level of lung cancer patients was quite higher as compared to the group of healthy people as per the values depicted in the research study. Second, HSP90 levels are substantially higher in pathologic type, differentiation degree, stage, and the existence of the lung, liver, and bone metastases ( P < 0.05). The level of HSP90 expression was largely impacted by a few factors such as sex, age, smoking, and tumour location ( P > 0.05). The ROC value for HSP90 was 0.599, while the area under the curve of HSP90 combined with other four tumour markers was 0.915 in the presented case study, indicating the presence of lung cancer. Patients with lung cancer had statistically significant differences in HSP90 expression levels before and after surgery ( P < 0.05). It is concluded that the expression level of plasma HSP90α in lung cancer patients increases remarkably; therefore, HSP90 can be used to monitor presence of lung cancer before and after surgery in the patients.

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A comprehensive survey on investigation techniques of exhaled breath (EB) for diagnosis of diseases in human body

Cited by 47 publications

References 86 publications

Analyzing the Treatment of Patients with Acute Exacerbation of COPD with the Aid of Intelligent Diagnosis Method

Analyzing the Treatment of Patients with Acute Exacerbation of COPD with the Aid of Intelligent Diagnosis Method

Walking and Activeness: The First Step toward the Prevention of Strokes and Mental Illness

Impact of HSP90α, CEA, NSE, SCC, and CYFRA21-1 on Lung Cancer Patients

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