A compressibility and compactibility study of real tableting mixtures: the effect of granule particle size

Šantl, Maja; Ilić, Ilija; Vrečer, Franc; Baumgartner, Stephan

doi:10.2478/v10007-012-0028-8

Cited by 50 publications

(19 citation statements)

References 24 publications

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“…Particle size of carriers influences flow properties [23], compressibility [24], oil adsorption and desorption [25]. The particle size was measured using the Laser diffraction technology from Malvern ® , Mastersizer ® 2000.…”

Section: Particle Size and Morphologymentioning

confidence: 99%

Comparative evaluation of porous silica based carriers for lipids and liquid drug formulations

Choudhari¹,

Reddy²,

Monsuur³

et al. 2014

Open Material Sciences

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Conversion of liquid and semisolid lipids into free flowing powders is an advantageous technique, as the carriers display high surface area, strong adsorption capacity, ease of processing, and ability to generate lipid loaded free flowing powders which can be converted to solid dosage forms like tablets and capsules. A combination of density, adsorption capacity and desorption is found to be of importance in the selection of the right adsorbent. Adsorbents like magnesium aluminium silicates (MAS), granulated fumed silica (GFS) and mesoporous silica gel (MSG) were characterized by flow property measurements, particle size, scanning electron microscopy (SEM) and pore structure by mercury (Hg) intrusion study. SEM results reveal adsorbent morphology, whereas an intrusion-extrusion study reveal pore size distributions. Tablets and capsules of oil loaded adsorbents were prepared by conventional methods. Oil loaded adsorbents were evaluated for the ability to convert oil into powder, easy of processing into tablets and capsules, and release of the loaded oil (Vitamin E) or active (Glyburide). All adsorbents possess good flow property while MSG has higher density than GFS and MAS. This helps to deliver maximum active per unit volume. A wider pore size distribution of MAS was observed in comparison to MSG and GFS. MAS exhibited poor oil release from powder and its formulations, whereas GFS demonstrated closely similar release to MSG. Maximum 70% oil loaded MSG can be delivered in tablet dosage form and MSG can deliver the highest amount in limited volume capsules due to its high density. Hence, lower density and poor oil release from MAS limit its applications in solid oral drug delivery, while both MSG and GFS proved to be suitable.

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Section: Particle Size and Morphologymentioning

confidence: 99%

Comparative evaluation of porous silica based carriers for lipids and liquid drug formulations

Choudhari¹,

Reddy²,

Monsuur³

et al. 2014

Open Material Sciences

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“…Higher value of A for granules of all drugs as compare to PG and direct compression formulation indicates higher degree of fragmentation which may be attributed to larger particle size of granules. Another reason for higher fragmentation might be presence of high-fragmenting material, i.e., lactose monohydrate in formulation (49). Granules for all drugs showed plastic deformation when the compression pressure was increased (50).…”

Section: Pressure-relative Density Relationshipmentioning

confidence: 99%

Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation

2014

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Abstract. In the present work, an attempt has been made to screen Prosopis africana seed gum (PG), anionic polymer for extended release tablet formulation. Different categories of drugs (charge basis) like diclofenac sodium (DS), chlorpheniramine maleate (CPM), and ibuprofen (IB) were compacted with PG and compared with different polymers (charge basis) like xanthan gum (XG), hydroxypropyl methyl cellulose (HPMC-K100M), and chitosan (CP). For each drug, 12 batches of tablets were prepared by wet granulation technique, and granules were evaluated for flow properties, compressibility, and compactibility by Heckel and Leuenberger analysis, swelling index, in vitro dissolution studies, etc. It has been observed that granules of all batches showed acceptable flowability. According to Heckel and Leuenberger analysis, granules of PG-containing compacts showed similar and satisfactory compressibility and compactibility compared to granules of other polymers. PG showed significant swelling (P<0.05) compared to HPMC, and better than CP and XG. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) study showed no interaction between drugs and polymers. From all PG-containing compacts of aforesaid drugs, drug release was sustained for 12 h following anomalous transport. Especially, polyelectrolyte complex formation retarded the release of oppositely charged drug (CPM-PG). However, extended release was noted in both anionic (DS) and nonionic (IB) drugs, maybe due to swollen gel. All compacts were found to be stable for 3-month period during stability study. This concludes that swelling and release retardation of PG has close resemblance to HPMC, so it can be used as extended release polymer for all types of drugs.

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“…In addition, the fixed angle value of the tablet granules produced in this study was categorized as good. Good compressibility is likely a consequence of lower bulk density and addition of filler increases density and decreases initial porosity/ volume of specific tablets [7]. Compressibility is influenced by flow rate of a tablet powder mixture.…”

Section: Methodsmentioning

confidence: 99%

Production of Unsaturated Fatty Acids Concentrate Tablets fromSardinellasp. Oil

2020

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Tablets are medicinal ingredients in solid dosage forms which are usually prepared with suitable pharmaceutical ingredients. In this study, unsaturated fatty acids concentrate from Sardinella sp. oil was used as raw material and then it was microencapsulated. The microcapsule was formulated into a tablet with proportion of 250 mg concentrated unsaturated fatty acids for each 450 mg tablet. Tablet granules were analyzed for compressibility, flow rate, and fixed angle. While, the tablets were determined for weight uniformity, released time, hardness, and tablet size uniformity. The results showed that compressibility, flow rate and fixed angle of the tablet granules were 5.6%; 10.36 g/sec; and 32.4° respectively. Tablets had 447.85 mg weight uniformity; 48'12" released time; and 0.775 kg hardness. In addition, the tablet size uniformity with diameter 10 mm and thickness 4 mm was 2.5. Based on the pharmacopoeia, the tablets of unsaturated fatty acids concentrate from Sardinella sp. oil had met these requirements, but optimization was still needed for improving the released time and hardness of the tablet.

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A compressibility and compactibility study of real tableting mixtures: the effect of granule particle size

Cited by 50 publications

References 24 publications

Comparative evaluation of porous silica based carriers for lipids and liquid drug formulations

Comparative evaluation of porous silica based carriers for lipids and liquid drug formulations

Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation

Production of Unsaturated Fatty Acids Concentrate Tablets fromSardinellasp. Oil

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