2020
DOI: 10.1016/j.ejphar.2020.173378
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A computational analysis of the effect of sevoflurane in a human ventricular cell model of long QT syndrome: Importance of repolarization reserve in the QT-prolonging effect of sevoflurane

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Cited by 5 publications
(3 citation statements)
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“…In order to understand how the changes of the channel kinetics or current density in I Ks might affect APD or QT interval, we mimicked the experimental data for the WT or the Q234K model and simulated action potentials across the transmural myocardium or ECG ( Itoh et al, 2009 ; Kojima et al, 2020 ). O’Hara and Rudy model was available for this simulation ( O'Hara et al, 2011 ), and we searched for appropriate parameters according to the experimental data under the Q234K heterozygous condition.…”
Section: Methodsmentioning
confidence: 99%
“…In order to understand how the changes of the channel kinetics or current density in I Ks might affect APD or QT interval, we mimicked the experimental data for the WT or the Q234K model and simulated action potentials across the transmural myocardium or ECG ( Itoh et al, 2009 ; Kojima et al, 2020 ). O’Hara and Rudy model was available for this simulation ( O'Hara et al, 2011 ), and we searched for appropriate parameters according to the experimental data under the Q234K heterozygous condition.…”
Section: Methodsmentioning
confidence: 99%
“…To examine the effects of propofol (10 μM) on human ventricular electrophysiology under conditions with normal (KCNQ1/KCNE1) and KCNQ1/KCNE1‐D85N I Ks , we incorporated the changes in I Ks conductance ( g Ks ) and V h caused by propofol (10 μM), obtained from the present patch‐clamp experiments. In addition to the modulation of I Ks , the effects of propofol (10 μM) on seven other major cardiac ionic currents were incorporated by reducing their conductances by the degree reported in the literature (Kojima et al, 2020). These ionic currents are Nav1.5 current (Stoetzer et al, 2016), transient outward K + current ( I to , Yang et al, 2015), I Ca,L (Hatakeyama et al, 2009), HERG current (Yang et al, 2015), inward rectifier K + current ( I K1 , Buljubasic et al, 1996), Na + /Ca 2+ exchanger current ( I NCX , Puttick & Terrar, 1992) and Na + ‐K + pump current ( I NaK , Kutchai et al, 1999).…”
Section: Methodsmentioning
confidence: 99%
“…There are available experimental data on the cellular transmural (endo-, mid-, and epicardial) heterogeneity across the wall and longitudinal (from apex to base) heterogeneity with distinctive cardiomyocyte properties ( Janse et al., 2012 ; Boukens et al., 2015 ; Solovyova et al., 2016 ). This issue was addressed in several simulation studies by us ( Markhasin et al., 2012 ; Solovyova et al., 2014 ; Khokhlova et al., 2017 ; 2018 ) and other authors ( Seemann et al., 2003 ; Bondarenko and Rasmusson, 2010 ; Maoz et al., 2014 ), including models of human cardiomyocytes starting from the original TNNP and ORd models of cell electrophysiology ( O’Hara et al., 2011 ; Christophe, 2013 ; Vandersickel et al., 2016 ; Kojima et al., 2020 ) to their recent updates ( Tomek et al., 2019 ; Margara et al., 2021 ). In recent articles from our group ( Khokhlova et al., 2020 ), the distinctions in the intrinsic parameters of contractile activity were shown to be essential for reproducing the distinctions we revealed in isolated cardiomyocyte experiments in response to changes in the mechanical conditions of contraction.…”
Section: Strengths and Limitationsmentioning
confidence: 99%