A computational approach for the identification of key genes and biological pathways of chronic lung diseases: a systems biology approach

Abstract

Background Chronic lung diseases are characterized by impaired lung function. Given that many diseases have shared clinical symptoms and pathogenesis, identifying shared pathogenesis can help the design of preventive and therapeutic strategies. This study aimed to evaluate the proteins and pathways of chronic obstructive pulmonary disease (COPD), asthma, idiopathic pulmonary fibrosis (IPF), and mustard lung disease (MLD). Methods and results After collecting the data and determining the gene list of each disease, gene expression changes were examined in comparison to healthy individuals. Protein–protein interaction (PPI) and pathway enrichment analysis were used to evaluate genes and shared pathways of the four diseases. There were 22 shared genes, including ACTB, AHSG, ALB, APO, A1, APO C3, FTH1, GAPDH, GC, GSTP1, HP, HSPB1, IGKC, KRT10, KRT9, LCN1, PSMA2, RBP4, 100A8, S100A9, TF, and UBE2N. The major biological pathways in which these genes are involved are inflammatory pathways. Some of these genes activate different pathways in each disease, leading to the induction or inhibition of inflammation. Conclusion Identification of the genes and shared pathways of diseases can contribute to identifying pathogenesis pathways and designing preventive and therapeutic strategies.

Long term respiratory morbidity of cesarean‐delivered second twin compared to their vaginally‐delivered sibling: A retrospective population‐based cohort study

“…[31][32][33] Pulmonary diseases, including bronchial asthma, exhibit complex and multifactorial etiologies. Research has highlighted the interplay of genetic predisposition, 34 familial trends, [35][36][37][38] environmental influences, [39][40][41] and the emerging field of omics, which encompasses proteomics, genomics, and microbiomes. [42][43][44] The multifactorial nature of the disease makes it challenging to isolate and study a single factor in isolation.…”

Evaluation of common protein biomarkers involved in the pathogenesis of respiratory diseases with proteomic methods: A systematic review

“…Most oxidative stress pathways lead to inflammation. Despite disease progression, the occurrence of inflammation can also induce apoptosis 10–12 …”

“…Despite disease progression, the occurrence of inflammation can also induce apoptosis. [10][11][12] Pulmonary disorders have also been shown in patients exposed to mustard gas and idiopathic pulmonary fibrosis (IPF) due to the activation of inflammatory pathways. 13 So far, common factors and pathways involved in the pathogenesis of RD have not been identified.…”