2024
DOI: 10.3390/brainsci14060620
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A Computational Model of Deep Brain Stimulation for Parkinson’s Disease Tremor and Bradykinesia

Sandeep Sathyanandan Nair,
Srinivasa Chakravarthy

Abstract: Parkinson’s disease (PD) is a progressive neurological disorder that is typically characterized by a range of motor dysfunctions, and its impact extends beyond physical abnormalities into emotional well-being and cognitive symptoms. The loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) leads to an array of dysfunctions in the functioning of the basal ganglia (BG) circuitry that manifests into PD. While active research is being carried out to find the root cause of SNc cell death, various… Show more

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