A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation

Li, Licong; Zhou, Jin; Sun, Honghao; Liu, Jing; Wang, Hongrui; Liu, Xiuling; Wang, Changyong

doi:10.1155/2020/8750167

Cited by 7 publications

(13 citation statements)

References 77 publications

(106 reference statements)

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“…( 2020 ), and Li et al. ( 2020 ) used the well-known computational model introduced by Tsodyks et al. ( 1998 ).…”

Section: Methods and Resultsmentioning

confidence: 99%

“…( 2019 ) and Li et al. ( 2020 ) used the extension of the model by Tsodyks et al. ( 1998 ) for astrocytic release of gliotransmitters based on previous studies (De Pittà et al., 2011 ; De Pittà & Brunel, 2016 ), and, in addition, Li et al.…”

Section: Methods and Resultsmentioning

confidence: 99%

“…( 1998 ) for astrocytic release of gliotransmitters based on previous studies (De Pittà et al., 2011 ; De Pittà & Brunel, 2016 ), and, in addition, Li et al. ( 2020 ) also used the previous studies by Destexhe et al. ( 1994 , 1998 ).…”

Section: Methods and Resultsmentioning

confidence: 99%

“…On the other hand, Li et al. ( 2020 ) explicitly specified 2D random placement of cells. We opted to categorize all models for which spatial organization was not defined by the authors as 2D random placement (Fig.…”

Section: Methods and Resultsmentioning

confidence: 99%

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Analysis of Network Models with Neuron-Astrocyte Interactions

2023

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Neural networks, composed of many neurons and governed by complex interactions between them, are a widely accepted formalism for modeling and exploring global dynamics and emergent properties in brain systems. In the past decades, experimental evidence of computationally relevant neuron-astrocyte interactions, as well as the astrocytic modulation of global neural dynamics, have accumulated. These findings motivated advances in computational glioscience and inspired several models integrating mechanisms of neuron-astrocyte interactions into the standard neural network formalism. These models were developed to study, for example, synchronization, information transfer, synaptic plasticity, and hyperexcitability, as well as classification tasks and hardware implementations. We here focus on network models of at least two neurons interacting bidirectionally with at least two astrocytes that include explicitly modeled astrocytic calcium dynamics. In this study, we analyze the evolution of these models and the biophysical, biochemical, cellular, and network mechanisms used to construct them. Based on our analysis, we propose how to systematically describe and categorize interaction schemes between cells in neuron-astrocyte networks. We additionally study the models in view of the existing experimental data and present future perspectives. Our analysis is an important first step towards understanding astrocytic contribution to brain functions. However, more advances are needed to collect comprehensive data about astrocyte morphology and physiology in vivo and to better integrate them in data-driven computational models. Broadening the discussion about theoretical approaches and expanding the computational tools is necessary to better understand astrocytes’ roles in brain functions.

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“…( 2020 ), and Li et al. ( 2020 ) used the well-known computational model introduced by Tsodyks et al. ( 1998 ).…”

Section: Methods and Resultsmentioning

confidence: 99%

Section: Methods and Resultsmentioning

confidence: 99%

Section: Methods and Resultsmentioning

confidence: 99%

Section: Methods and Resultsmentioning

confidence: 99%

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Analysis of Network Models with Neuron-Astrocyte Interactions

2023

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“…The GABA-induced activation of GABA B Rs results in glutamate release from astrocytes and activation of presynaptic group I metabotropic glutamate receptors (mGluRs), which persists in the bursts of interneuron action potential seven during the interneuron downstate, leading to enhancement of excitatory neurotransmission (Perea et al, 2016). Furthermore, computational modeling has recently been utilized to investigate the effects of exposure of astrocytes to different concentrations of exogenous GABA on excitatory presynaptic and postsynaptic endings (Li et al, 2020). The results show that increased GABA concentration not only reduces neuronal spikes but also facilitates astrocyte glutamate release by inducing Ca 2+ oscillations, leading to astrocyte-mediated presynaptic release and enhanced postsynaptic slow inward current (i.e., depolarizing currents).…”

Section: Gabaceptive Astrocytes Fine-tune Astrocyte-neuron Crosstalkmentioning

confidence: 99%

Astrocytes: GABAceptive and GABAergic Cells in the Brain

Liu

Feng²,

Wang³

et al. 2022

Front. Cell. Neurosci.

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Astrocytes, the most numerous glial cells in the brain, play an important role in preserving normal neural functions and mediating the pathogenesis of neurological disorders. Recent studies have shown that astrocytes are GABAceptive and GABAergic astrocytes express GABAA receptors, GABAB receptors, and GABA transporter proteins to capture and internalize GABA. GABAceptive astrocytes thus influence both inhibitory and excitatory neurotransmission by controlling the levels of extracellular GABA. Furthermore, astrocytes synthesize and release GABA to directly regulate brain functions. In this review, we highlight recent research progresses that support astrocytes as GABAceptive and GABAergic cells. We also summarize the roles of GABAceptive and GABAergic astrocytes that serve as an inhibitory node in the intercellular communication in the brain. Besides, we discuss future directions for further expanding our knowledge on the GABAceptive and GABAergic astrocyte signaling.

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