A computational model to investigate the influence of electrode lengths on the single probe bipolar radiofrequency ablation of the liver

Cheong, Jason K. K.; Yap, Shelley; Ooi, Ean Tat; Ooi, Ean Hin

doi:10.1016/j.cmpb.2019.04.028

Cited by 12 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fourthly, the bipolar needles used during the switching bRFA treatment were identical. The use of bipolar needles with different electrode lengths, such as those investigated by Cheong et al, 5 may lead to different treatment outcomes with different responses to input voltages and ablation duration. Similarly, combinations of monopolar and bipolar needles under the switching bRFA setting are worthy of future investigations.…”

Section: Discussionmentioning

confidence: 99%

“…There has been a surge in popularity in the use of bipolar radiofrequency ablation (bRFA) for treating liver cancer, as evident by the number of research studies that have been published over the past 5 years 1‐6 . Bipolar radiofrequency ablation differs from monopolar RFA (mRFA), in that the technique does not make use of grounding pads in order to complete the electrical circuit.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thermal and thermal damage responses during switching bipolar radiofrequency ablation employing bipolar needles: A computational study on the effects of different electrode configuration, input voltage and ablation duration

Cheong

Ooi

2020

Numer Methods Biomed Eng

Self Cite

View full text Add to dashboard Cite

Recent studies have demonstrated the effectiveness of switching bipolar radiofrequency ablation (bRFA) in treating liver cancer. Nevertheless, the clinical use of the treatment remains less common than conventional monopolar RFA – likely due to the lack of understanding of how the tissues respond thermally to the switching effect. The problem is exacerbated by the numerous possible switching combinations when bRFA is performed using bipolar needles, thus making theoretical deduction and experimental studies difficult. This article addresses this issue via computational modelling by examining if significant variation in the treatment outcome exists amongst six different electrode configurations defined by the X‐, C‐, U‐, N‐, Z‐ and O‐models. Results indicated that the tissue thermal and thermal damage responses varied depending on the electrode configuration and the operating conditions (input voltage and ablation duration). For a spherical tumour, 30 mm in diameter, complete ablation could not be attained in all configurations with 70 V input voltage and 5 minutes ablation duration. Increasing the input voltage to 90 V enlarged the coagulation zone in the X‐model only. With the other configurations, extending the ablation duration to 10 minutes was found to be the better at enlarging the coagulation zone.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thermal and thermal damage responses during switching bipolar radiofrequency ablation employing bipolar needles: A computational study on the effects of different electrode configuration, input voltage and ablation duration

Cheong

Ooi

2020

Numer Methods Biomed Eng

Self Cite

View full text Add to dashboard Cite

show abstract

“…Among others, numerous computational studies have been published in the last decades on mathematical modelling of RFA for treating tumors. The models available in literature are either one-compartment models or two-compartment models, utilizing different protocols of RF energy delivery, viz., continuous (Barauskas et al, 2008, Zorbas and Samaras, 2013, temperature-controlled (Shao et al, 2017a, Singh, 2018, Singh and Repaka, 2017a, Singh and Repaka, 2018a, Singh and Repaka, 2018c, Singh and Repaka, 2018b and impedance-controlled (Cheong et al, 2019, Trujillo et al, 2017, Trujillo et al, 2016.…”

Section: Multiscale Modelling Of Neurological Disorders and Machine Lmentioning

confidence: 99%

Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions

Singh

Melnik

2020

Electromagnetic Biology and Medicine

View full text Add to dashboard Cite

Percutaneous thermal ablation has proved to be an effective modality for treating both benign and malignant tumors in various tissues. Among these modalities, radiofrequency ablation (RFA) is the most promising and widely adopted approach that has been extensively studied in the past decades. Microwave ablation (MWA) is a newly emerging modality that is gaining rapid momentum due to its capability of inducing rapid heating and attaining larger ablation volumes, and its lesser susceptibility to the heat sink effects as compared to RFA. Although the goal of both these therapies is to attain cell death in the target tissue by virtue of heating above 50 o C, their underlying mechanism of action and principles greatly differs. Computational modelling is a powerful tool for studying the effect of electromagnetic interactions within the biological tissues and predicting the treatment outcomes during thermal ablative therapies. Such a priori estimation can assist the clinical practitioners during treatment planning with the goal of attaining successful tumor destruction and preservation of the surrounding healthy tissue and critical structures. This review provides current state-ofthe-art developments and associated challenges in the computational modelling of thermal ablative techniques, viz., RFA and MWA, as well as touch upon several promising avenues in the modelling of laser ablation, nanoparticles assisted magnetic hyperthermia and noninvasive RFA. The application of RFA in pain relief has been extensively reviewed from modelling point of view. Additionally, future directions have also been provided to improve these models for their successful translation and integration into the hospital work flow.

show abstract

Analysis of nonlinear bioheat transfer equation in magnetic fluid hyperthermia

et al. 2020

View full text Add to dashboard Cite

A computational model to investigate the influence of electrode lengths on the single probe bipolar radiofrequency ablation of the liver

Cited by 12 publications

References 45 publications

Thermal and thermal damage responses during switching bipolar radiofrequency ablation employing bipolar needles: A computational study on the effects of different electrode configuration, input voltage and ablation duration

Thermal and thermal damage responses during switching bipolar radiofrequency ablation employing bipolar needles: A computational study on the effects of different electrode configuration, input voltage and ablation duration

Thermal ablation of biological tissues in disease treatment: A review of computational models and future directions

Analysis of nonlinear bioheat transfer equation in magnetic fluid hyperthermia

Contact Info

Product

Resources

About