A Computational Study of the Magnitude and Direction of Migration Forces in Patient-specific Abdominal Aortic Aneurysm Stent-Grafts

Molony, David; Kavanagh, Eamon G.; Madhavan, Prakash; Walsh, Michael T.; McGloughlin, Timothy M.

doi:10.1016/j.ejvs.2010.06.001

Cited by 102 publications

(89 citation statements)

References 27 publications

(33 reference statements)

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“…It is becoming increasingly clear that evaluating the simple downward (y-direction) force acting on the device is not sufficient, and that the out-of-plane forces play an important role [18,40]. Our group is presently evaluating the out-of-plane configuration of crossed-limb stent-grafts.…”

Section: Future Workmentioning

confidence: 99%

“…Our group is presently evaluating the out-of-plane configuration of crossed-limb stent-grafts. Given that the recent studies indicate that forces in the anterior direction are significant [18,40], our group plans to carry out experimental studies to determine pullout forces at various anterior and lateral angulations. These would be important contributions to the understanding of stent-grafts, and the experimental studies could serve as references against which predicted forces from simulations could be compared.…”

Section: Future Workmentioning

confidence: 99%

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Computational Fluid Dynamics Modeling of Redundant Stent-Graft Configurations in Endovascular Aneurysm Repair

Tse

Shek

Nabovati

et al. 2010

Volume 2: Biomedical and Biotechnology Engineering

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During endovascular aneurysm repair (EVAR), if the stent-graft device is too long for a given patient the redundant (extra) length adopts a convex configuration in the aneurysm.Based on clinical experience, we hypothesize that redundant stent-graft configurations increase the downward force acting on the device, thereby increasing the risk of device dislodgement and failure. This work numerically studies both steady-state and physiologic pulsatile blood flow in redundant stent-graft configurations. Computational fluid dynamics simulations predicted a peak downward displacement force for the zero-, moderate-and severe-redundancy configurations of 7.36, 7.44 and 7.81 N, respectively for steady-state flow; and 7.35, 7.41 and 7.85 N, respectively for physiologic pulsatile flow. These results suggest that redundant stent-graft configurations in EVAR do increase the downward force acting on the device, but the clinical consequence depends significantly on device-specific resistance to dislodgement.ii

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Section: Future Workmentioning

confidence: 99%

Section: Future Workmentioning

confidence: 99%

Computational Fluid Dynamics Modeling of Redundant Stent-Graft Configurations in Endovascular Aneurysm Repair

Tse

Shek

Nabovati

et al. 2010

Volume 2: Biomedical and Biotechnology Engineering

View full text Add to dashboard Cite

show abstract

“…It was shown that aortic geometry presents curvature, angulations, and tortuosity that influence the magnitude and, most importantly, the direction of displacement forces, which are directed not only caudally, but rather anterolateraly or even cephalad. [12][13][14] This has clear implications for modifying the design of endovascular grafts, such as the enhancement of central fixation with suprarenal hooks and barbs or the accommodation of endografts onto the aortic bifurcation, which sustains the greatest percentage of displacement forces. 15 Computational studies can provide significant information on the importance of different geometrical features of endografts (angulation, curvature, tortuosity, length or diameter ratios of the different segments) on the risk of migration, overcoming several difficulties and limitations that clinical comparative studies would encounter in drawing similar conclusions.…”

Section: Biomechanical Approach Of Aortic Stent-grafts: What Is To Bementioning

confidence: 99%

Applying Findings of Computational Studies in Vascular Clinical Practice: Fact, Fiction, or Misunderstanding?

Georgakarakos

Gasser

Xenos

et al. 2014

Journal of Endovascular Therapy

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Computational mechanics and simulations comprise a promising tool used in current medical research to explore complex problems, and it is critically important to improving and individualizing services and products. 1 Computational simulations are particularly useful for investigating scientific queries that are difficult (or impossible) to approach with studies performed in human subjects or animal models. Today, this experimental approach has either partly or completely replaced laboratory testing. The computational sequence requires fundamentally three distinct work steps: (1) geometry reconstruction of the study model from medical images, (2) biomechanical simulation (finite element or fluidstructure interaction computation), and (3) interpretation of biomechanical parameters. Computational simulations have gained wider recognition in vascular practice as relates to rupture-risk prediction of abdominal aortic aneurysms (AAA) and the hemodynamic performance of stents and endografts used in the treatment of aortic aneurysms, as explained below.

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“…Interventional cardiovascular catheterization, such as stent and coiling are both of the advances to treat aneurysms [6][7][8], should stay in the body and have some complications, such as the displacement of the stent and the coil fall off from the aneurysm [9,10]. Considering the blood coagulation induced by the heating of radiofrequency ablation (RFA), the mechanism of aneurysm embolization and the advantages of simple operation, small trauma, low cost, faster recovery, high success rate, etc [11][12][13][14][15] , Qiao, et al proposed that RFA may be used to treat aneurysm by combining the mechanism of blood coagulation of RFA and aneurysm embolization [16].…”

Section: Introductionmentioning

confidence: 99%

Numerical simulation of RF catheter ablation for the treatment of arterial aneurysm

Guo

Nan

Qiao

2015

BME

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Abstract.Considering the blood coagulation induced by the heating of radio frequency ablation (RFA) and the mechanism of aneurysm embolization, we proposed that RFA may be used to treat arterial aneurysm. But the safety of this method should be investigated. A finite element method (FEM) was used to simulate temperature and pressure distribution in aneurysm with different electrode position, electric field intensity and ablation time. When the electrode is in the middle of the artery aneurysm sac, temperature rose clearly in half side of artery aneurysm, which is not suitable for RFA. Temperature rose in the whole aneurysm when the electrode is under the artery aneurysm orifice, which is suitable for the ablation therapy. And in this way, the highest temperature was 69.585 when power was 5.0 V/mm with 60 s. It can promote the coagulation and thrombosis generation in the aneurysm sac while the outside tissue temperature rises a little. Meanwhile, the pressure (10 Pa) at the top of aneurysm sac with electrode insertion is less than that (60 Pa) without electrode, so electrode implant may protect the aneurysm from rupture. The results can provide a theoretical basis for interventional treatment of aneurysm with RFA.

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A Computational Study of the Magnitude and Direction of Migration Forces in Patient-specific Abdominal Aortic Aneurysm Stent-Grafts

Cited by 102 publications

References 27 publications

Computational Fluid Dynamics Modeling of Redundant Stent-Graft Configurations in Endovascular Aneurysm Repair

Computational Fluid Dynamics Modeling of Redundant Stent-Graft Configurations in Endovascular Aneurysm Repair

Applying Findings of Computational Studies in Vascular Clinical Practice: Fact, Fiction, or Misunderstanding?

Numerical simulation of RF catheter ablation for the treatment of arterial aneurysm

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