The reduction in CO2 emissions has become an important issue as global environmental problems have become more serious. The replacement of conventional petroleum- and mineral-derived raw materials for building materials with local plant-based resources is expected to reduce CO2 emissions. This study examined the possibility of using compression-molded boards made from plant-based resources as sound-absorbing materials in rooms. Among plant resources, few studies have conducted detailed measurements of the sound absorption properties of boards compressed from reeds. When measuring the normal incidence sound absorption coefficient, a material layered with a reed compressed board, wood fiber insulation, and an air layer showed a peak in the sound absorption rate at approximately 850 Hz. This indicates the potential to effectively absorb noise in the frequency band of human voices (500–1000 Hz). By changing the layering of multiple sound-absorbing materials, the presence or absence of an air layer behind them, and the installation conditions of the sound-absorbing materials, and then measuring the sound absorption rate, variations were observed in the sound absorption rate and the frequency at which the peaks were observed. This provides guidelines for material configurations that exhibit sound absorption at specific frequencies.