2023
DOI: 10.1038/s41598-023-43003-2
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A computationally optimized broadly reactive hemagglutinin vaccine elicits neutralizing antibodies against influenza B viruses from both lineages

Michael A. Carlock,
Ted M. Ross

Abstract: Influenza B viruses (IBV) can cause severe disease and death much like influenza A viruses (IAV), with a disproportionate number of infections in children. Despite moving to a quadrivalent vaccine to include strains from both the B/Victoria and B/Yamagata lineages, vaccine effectiveness rates continue to be variable and low in many past seasons. To develop more effective influenza B virus vaccines, three novel IBV hemagglutinin (HA) vaccines were designed using a computationally optimized broadly reactive anti… Show more

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Cited by 6 publications
(1 citation statement)
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“…This method was utilized for synthesizing rHA and rNA proteins, capable of stimulating antibodies that induce broad responses, for providing long lasting protection against influenza virus strains that have undergone antigenic drift [18]. COBRA HA and NA virus-like particle vaccines stimulate antibodies with protective HAI and NAI responses against influenza A and B viruses in several animal models, including rodents, ferrets, and monkeys following vaccination [8,[19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%
“…This method was utilized for synthesizing rHA and rNA proteins, capable of stimulating antibodies that induce broad responses, for providing long lasting protection against influenza virus strains that have undergone antigenic drift [18]. COBRA HA and NA virus-like particle vaccines stimulate antibodies with protective HAI and NAI responses against influenza A and B viruses in several animal models, including rodents, ferrets, and monkeys following vaccination [8,[19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%