“…Protein denaturation is reversible de Wit and Swinkles (1980), Anema and McKenna (1996), Changani and others (1997), Chen and others (1998a) Protein denaturation is irreversible Ruegg and others (1977), Lalande and others (1985), Arnebrat and others (1987), Gotham and others (1992), Roef and de Kruif (1994), Karlsson and others (1996) Protein aggregation is irreversible Mulvihill and Donovan (1987), Anema and McKenna (1996), Changani and others (1997), Chen and others (1998a) Protein denaturation is the governing reaction Lalande and others (1985), Hege and Kessler (1986), Arnebrant and others (1987), Kessler and Beyer (1991), de Jong and others (1992) Protein aggregation is the governing reaction Lalande and René (1988), Gotham and others (1992), Delplace and others (1997) Formation of protein aggregates enable to de Jong and others (1992), Delplace and others (1997), van Asselt and others (2005) reduce fouling Only protein aggregates cause fouling Toyoda and others (1994) Fouling is considered to depend on protein de Jong and van del Linden (1992), de Jong and others (1992), Belmar-Beiny and others (1993), reactions only others (1994, 1997), Schreier and Fryer (1995), Grijspeerdt and others (2004), Sahoo and others (2005), Nema and Datta (2005) Fouling is considered to depend on protein Toyoda and others (1994), Georgiadis and others (1998), Georgiadis and Macchietto (2000), reactions as well as mass transfer Chen and others (1998aChen and others ( , 2000Chen and others ( , 2001, , Bansal an...…”