A Computer Program for Calculating Distribution Parameters for Drugs Behaving Nonlinearly That Is Based on Disposition Decomposition Analysis

Kinetic Evaluation of Nonlinear Drug Elimination by a Disposition Decomposition Analysis. Application to the Analysis of the Nonlinear Elimination Kinetics of Erythropoietin in Adult Humans

“…Completely Central Elimination-In this case, the qe function describes the total elimination process. From eq 4 it follows that (7) so that kd = AUDC (8) Thus, when the drug is only eliminated centrally, the kinetics is described by the following equation…”

A comparison of nonlinear pharmacokinetics of erythropoietin in sheep and humans

“…An alternative PK methodology referred to as the Disposition Decomposition Analysis (DDA) has been proposed as a more generally applicable means for analyzing nonlinear drug disposition [14][15][16][17][18]. By permitting the separation of the disposition elimination function from the distribution functions, the DDA methodology enables the determination of the Michaelis-Menten (MM) parameters, V m and k m [18].…”

Mean residence time of drugs administered non‐instantaneously and undergoing linear tissue distribution and reversible metabolism and linear or non‐linear elimination from the central compartment

“…The following MRT values have also been calculated previously20 from the IV data according to (1) and (2) in reference 20: M R q J V = 4.44 h and M R q J V = 3-59 h. The oral data were generated with the above disposition parameters and the following parameters: sf: = 1, fp, = 0, kap = 1 h-l, and k , = 0, where kap and k , are the first-order absorption rate constants of the drug and the interconversion metabolite, respectively. The values of AUC were generated using the LAGRAN program.24 Values of MRqyPO and MRTgPO were calculated according to (18) and (19) respectively.…”