A concanavalin A-coated piezoelectric crystal biosensor

Practical considerations of the QCM as a viscometer within the food industry: Performance deterioration with repeated use and surface roughness

“…There are limitations with using the crystal for high accuracy experiments. Barnes et al (1991) illustrated that the Sauerbrey equation predicts a lower Df from the experimental. Possibly due to the surface roughness of the crystal creating more surface area or the fact that the Sauerbrey equation does not take proper account of the viscoelastic properties of the coating.…”

“…The QCM has been shown to be an extremely sensitive mass detector (limits of detection (LOD) of 10 À12 g; Guilbault, 1983) and has often been used as a biosensor (Barnes, DÕSilva, Jones, & Lewis, 1991;Guilbault, 1983;Muramatsu, Dicks, Tamiya, & Karube, 1987) by coating the crystal surface with an enzyme or protein which will selectively bind the appropriate molecule, when doing so, causing a decrease in frequency. There are limitations with using the crystal for high accuracy experiments.…”

Biosensors Based on Biological Nanostructures

“…However, piezoelectric biosensors are relatively cheap, small and produce fast responses. (Barnes, Dsilva et al, 1991) The piezoelectric materials most today are inorganic, such as PB(Zr,Ti)O 3 . (Kobayashi, Okada et al, 2010).…”

Preclinical In Vivo Study of a Fluorescence Affinity Sensor for Short-Term Continuous Glucose Monitoring in a Small and Large Animal Model

“…Over the last several years, research into fluorescence affinity sensors (FASs) for glucose detection has steadily gained acceptance among scientists and clinicians through the introduction of a number of improved glucose-sensitive assays based on either the glucose-specific protein con-canavalin A (ConA), [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] artificial glucose-specific receptors based on boronate derivatives, 23,24 or an inactive form of the enzyme glucose oxidase. 25 There are several intrinsic advantages of an FAS over electrode-enzymatic sensors in terms of practicality for in vivo sensing.…”