Large scale, complex, networked enterprises, as may be considered (trans)national energy systems, multi-national manufacturing enterprises, smart cities a.s.o. are structures that can be characterized as systems of systems (SoS) and, as such, require specific modelling paradigms and control architectures to ensure their successful running. Their main characteristic is the necessity of solving practically one-of-a-kind problems with respect to the external context and internal configuration, thus dealing with dynamically evolving flows of data and information. The paper introduces the concept of intelligent cyber-enterprise, as an integrating paradigm that uses information and knowledge dynamics, in order to model and control SoS, especially focusing on the importance of appropriately adapt external and internal perception of an enterprise through a new generation of sensorial systems—the perceptive interfaces. The authors analyze sensing and perception in relation to intelligent cyber enterprise model and propose an implementation for a perceptive system interface.