A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

Jessen, Frank; Amariglio, Rebecca E.; Boxtel, M.P.J. van; Breteler, Monique M.B.; Ceccaldi, Mathieu; Chételat, Gaël; Dubois, Bruno; Dufouil, Carole; Ellis, Kathryn A.; Flier, Wiesje M. van der; Glodzik, Lidia; Harten, Argonde C. van; Leon, Mony J. de; McHugh, Pauline; Mielke, Michelle M.; Molinuevo, José Luís; Mosconi, Lisa; Osorio, Ricardo S.; Perrotin, Audrey; Petersen, Ronald C.; Rabin, Laura A.; Rami, Lorena; Reisberg, Barry; Rentz, Dorene M.; Sachdev, Perminder S.; Sayette, Vincent de La; Saykin, Andrew J.; Scheltens, Philip; Shulman, Melanie; Slavin, Melissa J.; Sperling, Reisa A.; Stewart, Robert; Uspenskaya, Olga; Vellas, Bruno; Visser, Pieter Jelle; Wagner, Michael

doi:10.1016/j.jalz.2014.01.001

Cited by 2,238 publications

(2,752 citation statements)

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“…As well as improving participant numbers, future studies need to examine even earlier stages of AD and MCI, namely subjective cognitive decline (Jessen et al, 2014), together with other forms of dementia. Despite these limitations, such studies show proof of concept in that such patients can be tested successfully using typical vMMN paradigms and that there is some evidence of potential abnormality in the vMMN in neurodegenerative disorders which warrants further investigation.…”

Section: Summary In Neurodegenerative Disordersmentioning

confidence: 99%

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Kremláček

Kreegipuu

Tales

et al. 2016

Cortex

119

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The visual mismatch negativity (vMMN) response is an event-related potential (ERP) component, which is automatically elicited by events that violate predictions based on prior events. VMMN experiments use visual stimulus repetition to induce predictions, and vMMN is obtained by subtracting the response to rare unpredicted stimuli from those to frequent stimuli. One increasingly popular interpretation of the mismatch response postulates that vMMN, similar to its auditory counterpart (aMMN), represents a prediction error response generated by cortical mechanisms forming probabilistic representations of sensory signals. Here we discuss the physiological and theoretical basis of vMMN and review thirty-three studies from the emerging field of its clinical applications, presenting a meta-analysis of findings in schizophrenia, mood disorders, substance abuse, neurodegenerative disorders, developmental disorders, deafness, panic disorder and hypertension. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensory modality and thus of vital importance in environmental information processing and response, and a modality which arguably may be more sensitive to some pathological changes. However, due to the relative infancy of research in vMMN compared to aMMN in clinical populations its potential for clinical application is not yet fully appreciated. The aim of this review and meta-analysis therefore is to present, in a detailed systematic manner, the findings from clinically-based vMMN studies, to discuss their potential impact and application, to raise awareness of this measure and to improve our understanding of disease upon fundamental aspects of visual information processing. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensor...

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Section: Summary In Neurodegenerative Disordersmentioning

confidence: 99%

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Kremláček

Kreegipuu

Tales

et al. 2016

Cortex

119

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“…Memory clinic patients with Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI) are very heterogeneous groups. SCI patients report subjective changes in cognitive performance without objective measurable impairment (Sperling et al, 2011) (Jessen et al, 2014a). MCI has been defined as both subjective and objective cognitive impairment in patients without dementia (Petersen et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia

Enache

Solomon

Cavallin

et al. 2016

Neurobiology of Aging

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PostprintThis is the accepted version of a paper published in Neurobiology of Aging. This paper has been peerreviewed but does not include the final publisher proof-corrections or journal pagination. Citation for the original published paper (version of record):Enache, D., Solomon, A., Cavallin, L., Kåreholt, I., Kramberger, M G. et al. (2016) CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia. Neurobiology of Aging AbstractThe aim of this study was to explore cross-sectional associations between CAIDE Dementia Risk Score and dementia-related CSF and neuroimaging biomarkers in 724 memory clinic patients without dementia from the Memory Clinic at Karolinska University Hospital Huddinge, Sweden. We additionally evaluated the score's capacity to predict dementia. Two risk score versions were calculated: one including age, gender, obesity, hyperlipidaemia, and hypertension; and one additionally including APOE ε4 carrier status. CSF was analysed for amyloid β (Aβ), total tau (t-tau), and phosphorylated tau (p-tau). Visual assessments of medial temporal lobe atrophy (MTA), global cortical atrophy-frontal subscale (GCA-F) and Fazekas scale for white matter changes (WMC) were performed. Higher CAIDE Dementia Risk Score (version without APOE) was significantly associated with higher t-tau, more severe MTA, WMC and GCA-F. Higher CAIDE Dementia Risk Score (version with APOE) was associated with reduced Aβ, more severe MTA and WMC. CAIDE Dementia Risk Score version with APOE seemed to predict dementia better in this memory clinic population with short follow-up than the version without APOE.3

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“…An important consideration in the current evidence regarding SCI and affective symptoms is the lack of consistency in SCI assessment, making it difficult to compare findings across studies (Abdulrab & Heun, 2008;Jessen et al, 2014). SCI measures in this review ranged from single-item yes/no responses, to investigator-developed instruments, to established batteries of self-reported cognitive complaints.…”

Section: Sci Measurementmentioning

confidence: 99%

“…Several related constructs have been used to operationalize SCI, including subjective memory complaints, perceived forgetfulness, or cognitive concerns (Abdulrab & Heun, 2008;Jessen et al, 2014). SCI is common among older adults, with prevalence rates ranging from 15% to 50% across studies (Minett, Da Silva, Ortiz, & Bertolucci, 2008;Reid & Maclullich, 2006); however, it is also decidedly heterogeneous in its clinical presentation as well as long-term cognitive outcomes (Donovan et al, 2014).…”

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confidence: 99%

Subjective Cognitive Impairment and Affective Symptoms: A systematic review

2016

The Gerontologist

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Purpose of Study: Subjective cognitive impairment (SCI) has been argued to reflect affective symptoms (i.e., depression and anxiety) rather than actual cognitive issues. Although a number of studies exist that look at the associations between SCI and affective symptoms, no review is available to aggregate this disparate literature. We addressed this gap by conducting a systematic review to better understand the relationships among SCI and affective symptoms among older adults in both community and clinical settings. Design and Methods: We reviewed available literature per the criteria of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Weight of evidence (WoE) ratings and narrative synthesis were completed for 58 articles. Results: A majority of studies focused on community-based samples (n = 40). Approximately half (53%) of the articles reviewed met high WoE criteria for the current review. Cross-sectional findings consistently identified a positive relationship among SCI and affective symptoms. Findings from available longitudinal studies (n = 9) were mixed but suggested a possible reciprocal relationship among SCI and depression. The relationship between SCI and anxiety appeared to be driven by fears over loss of function. Following consultation with health professionals, the association between SCI and anxiety was diminished or eliminated. Implications: Although SCI is consistently related to affective symptoms in older adults cross-sectionally, more longitudinal work is needed to understand their temporal relationship. Improved measurement of SCI would support a deeper understanding of the impact of SCI on psychological well-being.

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A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

Cited by 2,238 publications

References 60 publications

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia

Subjective Cognitive Impairment and Affective Symptoms: A systematic review

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