A concise synthesis of (+)-goniofufurone, (+)-7-epi-goniofufurone, (+)-crassalactones B and C

Recent Advances in Total Synthesis of Bioactive Furo[3,2‐b]furanone Natural Products

“…Using bis‐ Weinreb amide 59 as starting material, a synthesis of ent ‐(−)‐crassalactone C was later reported by the same group . Recently, using a modified version of Prasad's approach, a concise synthesis of (+)‐ 1 and 25 – 27 was reported by Chen et al …”

Synthesis of anti-proliferative [3.3.0]furofuranone derivatives by lactonization and functionalization of C-glycosyl compounds

“…Just to mention some of them, the total synthesis of natural (+)-Goniofufurone was early reported by a non-classical Wittig reaction on furanolactone obtained from D-glucose. [22,23] A great number of total syntheses of (+)-Goniofufurone have been reported [18,[24][25][26][27][28] and a photochemical approach has been recently reported. [29] Crassalactone C is also the subject of many investigations and its first total synthesis was reported from D-xylose in a multistep sequence by Popsavin et al [30] An expeditious enantiospecific synthesis involving a ring-closing metathesis reaction was also reported by Prasad et al [31] Together with the development of synthetic approaches, Popsavin's group is fully implicated in the synthesis of many series of lactone derivatives with significant cytotoxic activity against human tumor cell lines.…”