A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Huang, Guan Jhong; Reddy, Mopur Vijaya Bhaskar; Kuo, Ping Chung; Huang, Chieh Hung; Shih, Hung Cheng; Lee, E. Jian; Yang, Mei; Leu, Yann Lii; Wu, Tian Shung

doi:10.1016/j.ejmech.2011.12.008

Cited by 35 publications

(23 citation statements)

References 21 publications

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“…Huang et al . () has reported that reduction of NO production and inhibition of iNOS have been established as therapeutic approaches for the treatment of inflammation.…”

Section: Resultsmentioning

confidence: 99%

Anti-Diabetic and Anti-Inflammatory Potential of the Edible Brown AlgaHizikia Fusiformis

Han

Ali

Woo

et al. 2015

Journal of Food Biochemistry

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Hizikia fusiformis, an edible brown alga, is found abundantly in Korea, Japan and China. We investigated the methanolic (MeOH) extract of H. fusiformis and its different fractions for anti-diabetic and anti-inflammatory activity. Of these, the CH2Cl2 and EtOAc fractions exhibited remarkable inhibitory activities against ONOO − free radicals, PTP1B and α-glucosidase. Repeated column chromatography based on bioactivity-guided fractionation yielded fucosterol and fucoxanthin from the CH2Cl2 fraction and these two compounds inhibited tyrosine nitration in a dose-dependent manner. Furthermore, the CH2Cl2 fraction inhibited nitric oxide production and significantly suppressed expression of inducible nitric oxide synthase (iNOS) protein, whereas the EtOAc fraction effectively inhibited t-butyl hydroperoxide (t-BHP)-induced generation of reactive oxygen species in RAW 264.7 cells. The results demonstrate the potential anti-diabetic and antiinflammatory activities of H. fusiformis. PRACTICAL APPLICATIONSHizikia fusiformis has been used as a health food for hundreds of years in northwest Pacific areas. It is well known for its distinctive flavor and high content of calcium, vitamin A, inorganic salt, iodine and dietary fiber, all of which enable prevention of various diseases including diabetes, high blood pressure, colorectal cancer, constipation, thyroid cancer and beriberi. Modern research has suggested its potential for treatment of arteriosclerosis and osteoporosis. The findings of this study demonstrate the anti-diabetic and anti-inflammatory activities of the methanolic (MeOH) extracts of H. fusiformis and supports use of this seaweed as a functional food and a potential anti-diabetic.

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“…Huang et al . () has reported that reduction of NO production and inhibition of iNOS have been established as therapeutic approaches for the treatment of inflammation.…”

Section: Resultsmentioning

confidence: 99%

Anti-Diabetic and Anti-Inflammatory Potential of the Edible Brown AlgaHizikia Fusiformis

Han

Ali

Woo

et al. 2015

Journal of Food Biochemistry

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“…; Huang et al . ). Considering that prostaglandin E 2 , a product of COX‐2, is one of the strongest inflammatory mediators, it is plausible to propose the protection elicited by exercise training may be associated to prostaglandin E 2 blockade through COX‐2 downregulation.…”

Section: Discussionmentioning

confidence: 97%

Previous physical exercise alters the hepatic profile of oxidative‐inflammatory status and limits the secondary brain damage induced by severe traumatic brain injury in rats

Castro¹,

Ferreira²,

Busanello³

et al. 2017

The Journal of Physiology

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Although systemic responses have been described after traumatic brain injury (TBI), little is known regarding potential interactions between brain and peripheral organs after neuronal injury. Accordingly, we aimed to investigate whether a peripheral oxidative/inflammatory response contributes to neuronal dysfunction after TBI, as well as the prophylactic role of exercise training. Animals were submitted to fluid percussion injury after 6 weeks of swimming training. Previous exercise training increased mRNA expression of X receptor alpha and ATP-binding cassette transporter, and decreased inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF)-α and interleukin (IL)-6 expression per se in liver. Interestingly, exercise training protected against hepatic inflammation (COX-2, iNOS, TNF-α and IL-6), oxidative stress (decreases in non-protein sulfhydryl and glutathione, as well as increases in 2',7'-dichlorofluorescein diacetate oxidation and protein carbonyl), which altered hepatic redox status (increases in myeloperoxidase and superoxide dismutase activity, as well as inhibition of catalase activity) mitochondrial function (decreases in methyl-tetrazolium and Δψ, as well as inhibition of citrate synthase activity) and ion gradient homeostasis (inhibition of Na ,K -ATPase activity inhibition) when analysed 24 h after TBI. Previous exercise training also protected against dysglycaemia, impaired hepatic signalling (increase in phosphorylated c-Jun NH2-terminal kinase, phosphorylated decreases in insulin receptor substrate and phosphorylated AKT expression), high levels of circulating and neuronal cytokines, the opening of the blood-brain barrier, neutrophil infiltration and Na ,K -ATPase activity inhibition in the ipsilateral cortex after TBI. Moreover, the impairment of protein function, neurobehavioural (neuromotor dysfunction and spatial learning) disability and hippocampal cell damage in sedentary rats suggests that exercise training also modulates peripheral oxidative/inflammatory pathways in TBI, which corroborates the ever increasing evidence regarding health-related outcomes with respect to a physically active lifestyle.

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“…In addition, previous studies have illustrated that high S100A12 expression and increased serum levels associate with patients suffering inflammatory diseases . Moreover, some studies verified that both pro‐inflammatory and anti‐inflammatory cytokines in cells could be inhibited via depressing the extracellular signal‐regulated kinase (ERK) signaling pathway . Meanwhile, S100A12 is proved to suppress pro‐inflammatory and anti‐inflammatory cytokines, indicating that S100A12 could regulate pro‐ and anti‐inflammatory cytokines by activating the ERK signaling pathway .…”

Section: Introductionmentioning

confidence: 97%

Retracted: Effects of S100A12 gene silencing on serum levels of anti‐inflammatory/pro‐inflammatory cytokines in septic rats through the ERK signaling pathway

Wen

Han

Wang

et al. 2018

J of Cellular Biochemistry

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We explored the effect of S100A12 gene on serum levels of anti-inflammatory/pro-inflammatory cytokines in septic rats by activating the extracellular signal-regulated kinase (ERK) signaling pathway. A total of 180 specific pathogen-free (SPF) rats were purchased to establish cecal ligation and puncture (CLP) model. Rats were assigned into the sham, model, empty vector, S100A12 siRNA, epidermal growth factor (EGF), and S100A12 siRNA + EGF groups. The expressions of S100A12, ERK-1, ERK-2, cPLA2, and NF-κB in liver tissues of rats among six groups were detected by RT-qPCR and western blotting. ELISA was used to determine serum levels of IL-1β, IL-10, TNF-α, procalcitonin (PCT), and C-reactive protein (CRP). Pearson correlation analysis was conducted to measure correlations. Cell apoptosis of rats among six groups was detected by Tunel staining. The expressions of S100A12, ERK-1, ERK-2, cPLA2, and NF-κB decreased in the S100A12 siRNA group while increased in the EGF group compared with the model group. S100A12 mRNA expression was positively correlated with mRNA expressions of related genes in the ERK signaling pathway (ERK-1, ERK-2, cPLA2, and NF-κB) in the model and empty vector groups. Expressions of IL-1β, IL-6, TNF-α, PCT, and CRP in the EGF group were higher than those in the model group, but were lower than those in the S100A12 siRNA group. Compared with the model group, cell apoptosis decreased in the S100A12 siRNA group but that increased in the EGF group. We demonstrates that S100A12 gene silencing decreases serum levels of anti-inflammatory/pro-inflammatory cytokines in septic rats by inhibiting the ERK signaling pathway.

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A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

Cited by 35 publications

References 21 publications

Anti-Diabetic and Anti-Inflammatory Potential of the Edible Brown AlgaHizikia Fusiformis

Anti-Diabetic and Anti-Inflammatory Potential of the Edible Brown AlgaHizikia Fusiformis

Previous physical exercise alters the hepatic profile of oxidative‐inflammatory status and limits the secondary brain damage induced by severe traumatic brain injury in rats

Retracted: Effects of S100A12 gene silencing on serum levels of anti‐inflammatory/pro‐inflammatory cytokines in septic rats through the ERK signaling pathway

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