A conducting polymer with enhanced electronic stability applied in cardiac models

Mawad, Damia; Mansfield, Catherine; Lauto, Antonio; Perbellini, Filippo; Nelson, Geoffrey W.; Tonkin, Joanne; Bello, Sean O.Z.; Carrad, Damon J.; Micolich, A. P.; Mahat, Mohd Muzamir; Furman, Jennifer L.; Payne, David J.; Lyon, Alexander R.; Gooding, J. Justin; Harding, Siân E.; Terracciano, Cesare M.; Stevens, Molly M.

doi:10.1126/sciadv.1601007

Cited by 190 publications

(204 citation statements)

References 63 publications

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“…To show the promise of conductive scaffolds at the tissue‐level, Mawad et al performed interesting ex vivo and in vivo experiments. The group adhered PANI to a chitosan film using phytic acid as binding agent.…”

Section: Conductive Scaffolds For Cardiac Tissue Engineeringmentioning

confidence: 99%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

118

102

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Tissue engineering is a promising therapeutic approach in medicine, targeting the replacement of a diseased tissue with a healthy one grown within an artificial scaffold. Due to the high prevalence of cardiac and brain‐related ailments that involve some necrosis of tissue, cardiac and neuronal tissue engineering are intensely studied fields in regenerative medicine. A growing trend in the use of conductive scaffolds for the growth of these tissues has been witnessed recently. While the results are irrefutable, the mechanism of how an electrically conducting scaffold interacts with an electroactive tissue remains has remained elusive. An up‐to‐date summary of all work done in the field is reported, with a special focus on the specific contribution of the conductive scaffold on the performance of the formed tissue. The cell–scaffold electronic interface is then explored from an electrical engineering perspective. The electronic configuration of the system and the mechanisms and governing factors controlling the ability of a conductive scaffold to support cardiac and neuronal tissues are discussed. Using several simulations, the required conductivity of the scaffold in order for it to be suitable for tissue engineering—which also depends on the nature of the charge carriers—is also discussed.

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Section: Conductive Scaffolds For Cardiac Tissue Engineeringmentioning

confidence: 99%

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Burnstine‐Townley

Eshel

Amdursky

2019

Adv Funct Materials

118

102

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“…The formation of conductive blended polymers composed of a biomolecular polymer together with an organic conductor one is discussed in detail above (Section ). Several works used conductive biomolecular polymers, and mainly collagen‐, gelatin‐, or chitosan‐based ones, for cardiac and neuronal tissue engineering applications . Indeed, in most of these studies, the biomolecular polymer was mixed or coated with a traditional organic conductive polymer, and in a few studies, carbon nanotubes were blended into the biomolecular polymer for enabling the electrical conductivity.…”

Section: Perspective and Future Directionsmentioning

confidence: 99%

Macroscale Biomolecular Electronics and Ionics

2018

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www.advmat.de www.advancedsciencenews.com modern semiconductor-based electronic processing. The melanin story is also an archetype of the more recent "DNA-debate" and questions as to whether proteins, lipids, polysaccharides, etc., can intrinsically sustain electronic conduction and hence ET in the solid state. [13,31,32,41] That said, it is now appropriate and timely to introduce the basic concepts of ionic conduction.

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“…It is well known that the electrical pulse signal in the infarct region is interdicted following the occurrence of MI, and introduction of electrical conductivity into the biomaterials has been shown to be an effective approach to promote the cardiac function after MI . However, fixing conductive patches to the myocardium through conventional surgical suture or light irradiation could elicit an inflammatory reaction or multilevel oxidative stress that affects the regeneration process. Therefore, development of conductive adhesive that can be conveniently administered by simply painting on the heart surface will undoubtedly be a more feasible approach to the clinical treatment of MI.…”

mentioning

confidence: 99%

Paintable and Rapidly Bondable Conductive Hydrogels as Therapeutic Cardiac Patches

et al. 2018

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In recent years, cardiac patches have been developed for the treatment of myocardial infarction. However, the fixation approaches onto the tissue through suture or phototriggered reaction inevitably cause new tissue damage. Herein, a paintable hydrogel is constructed based on Fe -triggered simultaneous polymerization of covalently linked pyrrole and dopamine in the hyperbranched chains where the in situ formed conductive polypyrrole also uniquely serves to crosslink network. This conductive and adhesive hydrogel can be conveniently painted as a patch onto the heart surface without adverse liquid leakage. The functional patch whose conductivity is equivalent to that of normal myocardium is strongly bonded to the beating heart within 4 weeks, accordingly efficiently boosting the transmission of electrophysiological signals. Eventually, the reconstruction of cardiac function and revascularization of the infarct myocardium are remarkably improved. The translatable suture-free strategy reported in this work is promising to address the human clinical challenges in cardiac tissue engineering.

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A conducting polymer with enhanced electronic stability applied in cardiac models

Abstract: Researchers develop sutureless conductive patch with enhanced biostability and effect on heart conduction velocity.

Cited by 190 publications

References 63 publications

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Conductive Scaffolds for Cardiac and Neuronal Tissue Engineering: Governing Factors and Mechanisms

Macroscale Biomolecular Electronics and Ionics

Paintable and Rapidly Bondable Conductive Hydrogels as Therapeutic Cardiac Patches

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