A conductive sodium alginate and carboxymethyl chitosan hydrogel doped with polypyrrole for peripheral nerve regeneration

Bu, Ying; Xu, Haixing; Li, Xin; Xu, Wenjin; Yin, Yi; Dai, Hongyue; Wang, Xiaobin; Huang, Zhijun; Xu, Ping

doi:10.1039/c8ra01059e

Cited by 134 publications

(74 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, CNTs can be applied to electron-emitting fibrous polymers to improve mechanical strength [165]. Shin et al synthesized functional cardiac patches by seeding neonatal rat cardiomyocytes on CNT-incorporated photo crosslinkable gelatin methacrylate (GelMA) hydrogels (Figure 15) [166]. In this study, the electrically conductive networks within a porous gelatin framework utilized by CNTs showed an improvement in cell-cell coupling and adhesion of cardiac cells.…”

Section: Cardiac Tissue Engineeringmentioning

confidence: 78%

See 1 more Smart Citation

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Min¹,

Koh²

2018

Preprint

View full text Add to dashboard Cite

In the field of tissue engineering, conductive hydrogels have been the most effective biomaterials to mimic the biological and electrical properties of tissues in the human body. The main advantages of conductive hydrogel include not only its physical properties, but also its adequate electrical properties, thus providing electrical signals to cells efficiently. However, when introducing a conductive material into a non-conductive hydrogel, a conflicting relationship between the electrical and mechanical properties may develop. This review examines the strengths and weaknesses of the generation of conductive hydrogels using various conductive materials and introduces the use of these conductive hydrogels in tissue engineering applications.

show abstract

Section: Cardiac Tissue Engineeringmentioning

confidence: 78%

“…(a) Successfully synthesized CNT-GelMA conductive hydrogel and (b) improved cardiac cell adhesion and alignment on CNT-GelMA. In this study, CNTs improved cell-cell coupling and cardiac cell adhesion (reproduced with permission from [166]). …”

Section: Cardiac Tissue Engineeringmentioning

confidence: 99%

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Min¹,

Koh²

2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, it is necessary to develop a biomaterial by which CPs could be applied to the soft tissue of a living body. To overcome such weaknesses, CPs-based hydrogels have been actively developed [17][18][19]. The multifaceted challenge in tissue engineering is to find an ideal hydrogel prepolymer that can mimic the biology of human tissues in terms of structure, function, and performance [20].…”

mentioning

confidence: 99%

“…In addition, a method for preparing CP-based hydrogels has been studied. It was shown that conductivity could be affected by physically inserting CPs between the hydrogel chains, and then attaching the CPs to the hydrogel using ionic or covalent bonds [17,33].When cross-linking polyvinyl polymers, the use of gamma-ray irradiation induces free radical formation of both carbon atoms (in the polyvinyl polymer) and hydrogen atoms (in water) that promotes the formation of C-C bonds for cross-linking [34]. The gamma-ray cross-linking method offers many advantages in that reactions are simple and easy to induce in diverse environments (e.g., at low temperature in solid, gas, and liquid states) and without chemical additives (e.g., cross-linking agent, initiators, and catalysts).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Gamma Ray-Induced Polymerization and Cross-Linking for Optimization of PPy/PVP Hydrogel as Biomaterial

et al. 2020

View full text Add to dashboard Cite

Conducting polymer (CP)-based hydrogels exhibit the behaviors of bending or contraction/relaxation due to electrical stimulation. They are similar in some ways to biological organs and have advantages regarding manipulation and miniaturization. Thus, these hydrogels have attracted considerable interest for biomedical applications. In this study, we prepared PPy/PVP hydrogel with different concentrations and content through polymerization and cross-linking induced by gamma-ray irradiation at 25 kGy to optimize the mechanical properties of the resulting PPy/PVP hydrogel. Optimization of the PPy/PVP hydrogel was confirmed by characterization using scanning electron microscopy, gel fraction, swelling ratio, and Fourier transform infrared spectroscopy. In addition, we assessed live-cell viability using live/dead assay and CCK-8 assay, and found good cell viability regardless of the concentration and content of Py/pTS. The conductivity of PPy/PVP hydrogel was at least 13 mS/cm. The mechanical properties of PPy/PVP hydrogel are important factors in their application for biomaterials. It was found that 0.15PPy/PVP20 (51.96 ± 6.12 kPa) exhibited better compressive strength than the other samples for use in CP-based hydrogels. Therefore, it was concluded that gamma rays can be used to optimize PPy/PVP hydrogel and that biomedical applications of CP-based hydrogels will be possible.Polymers 2020, 12, 111 2 of 11 due to its excellent biocompatibility and environmental stability [3,4,14]. In addition, PPy has the advantage of the range of its electrical conductivity spanning from 10 to 100 S/cm [15]. However, PPy has the disadvantage of being brittle and mechanically unstable due to its conjugated chain structure [16]. Thus, existing CP-based biomaterials have limited use in living bodies because they are too hard and brittle [4,8]. Therefore, it is necessary to develop a biomaterial by which CPs could be applied to the soft tissue of a living body. To overcome such weaknesses, CPs-based hydrogels have been actively developed [17][18][19]. The multifaceted challenge in tissue engineering is to find an ideal hydrogel prepolymer that can mimic the biology of human tissues in terms of structure, function, and performance [20]. One of the major issues in electroactive and conductive tissue engineering is the fabrication of multifunctional hydrogels with native-like biological, electrical, and mechanical properties. Therefore, the incorporation of conductive nanomaterials into hydrogels has gained substantial interest as it not only increases the electrical conductivity, but also improves the elasticity and biological activity relative to the pure hydrogel [21,22].Hydrogel is a three-dimensional network structure with a polymer chain bonded through covalent and/or secondary bonds, which enables strong hydrogen bonding with water molecules. Hydrogel can contain a large amount of water, and when in contact with water shows substantial swelling. Even so, it does not easily decompose or dissolve in water. In addition, its mechanical s...

show abstract

Chitosan for Sensors and Electrochemical Applications

Silva

Batista²,

Santin

2019

Chitin and Chitosan

View full text Add to dashboard Cite

A conductive sodium alginate and carboxymethyl chitosan hydrogel doped with polypyrrole for peripheral nerve regeneration

Abstract: Polymer materials with electrically conductive properties have good applications in their respective fields because of their special properties.

Cited by 134 publications

References 49 publications

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Gamma Ray-Induced Polymerization and Cross-Linking for Optimization of PPy/PVP Hydrogel as Biomaterial

Chitosan for Sensors and Electrochemical Applications

Contact Info

Product

Resources

About