A cone-shaped 3D carbon nanotube probe for neural recording

Su, Hsin-Hao; Lin, Chia‐Jung; Yen, Shiang-Jie; Chen, Yung-Chan; Chen, Chang-Hsiao; Yeh, Shih-Rung; Fang, Weileun; Chen, Hsin; Yao, Da‐Jeng; Chang, Y. C.; Yew, Tri‐Rung

doi:10.1016/j.bios.2010.06.015

Cited by 42 publications

(24 citation statements)

References 41 publications

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“…Electrochemical characterization of the oxygen plasma-treated three dimensional CNT probes revealed lower impedance and higher capacitance compared with the bare silicon tip. Furthermore, the oxygen treated CNT probes were employed to record signals of a crayfish nerve cord (Su et al, 2010). …”

Section: Carbon Nanotubes For Electrical Neuronal Interfacingmentioning

confidence: 99%

Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

Bareket¹,

Hanein²

2013

Front. Neural Circuits

130

120

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Carbon nanotube (CNT) coatings have been demonstrated over the past several years as a promising material for neuronal interfacing applications. In particular, in the realm of neuronal implants, CNTs have major advantages owing to their unique mechanical and electrical properties. Here we review recent investigations utilizing CNTs in neuro-interfacing applications. Cell adhesion, neuronal engineering and multi electrode recordings with CNTs are described. We also highlight prospective advances in this field, in particular, progress toward flexible, bio-compatible CNT-based technology.

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Section: Carbon Nanotubes For Electrical Neuronal Interfacingmentioning

confidence: 99%

Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

Bareket¹,

Hanein²

2013

Front. Neural Circuits

130

120

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“…Accordingly, CNTs have been suggested by several studies as a future material for neuronal stimulation applications and several fabrication schemes have been studied. Primarily, direct growth of CNT electrodes (Wang et al 2006; Gabay et al 2007; Su et al 2010) as well as CNT coatings of metal electrodes by electro-polymerization (Keefer et al 2008), drop coating from a solution (Gabriel et al 2009) and micro-contact printing (Fuchsberger et al 2011) on a rigid support were described. To accommodate flexibility, CNT transfer onto a polymeric support (Su, Lin et al 2009; Tsai et al 2009; Carnahan et al 2010; Chang-Jian et al 2010) was recently presented.…”

Section: Introductionmentioning

confidence: 99%

All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation

David‐Pur

Bareket

Beit-Yaakov

et al. 2013

Biomed Microdevices

120

122

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Neuro-prosthetic devices aim to restore impaired function through artificial stimulation of the nervous system. A lingering technological bottleneck in this field is the realization of soft, micron sized electrodes capable of injecting enough charge to evoke localized neuronal activity without causing neither electrode nor tissue damage. Direct stimulation with micro electrodes will offer the high efficacy needed in applications such as cochlear and retinal implants. Here we present a new flexible neuronal micro electrode device, based entirely on carbon nanotube technology, where both the conducting traces and the stimulating electrodes consist of conducting carbon nanotube films embedded in a polymeric support. The use of carbon nanotubes bestows the electrodes flexibility and excellent electrochemical properties. As opposed to contemporary flexible neuronal electrodes, the technology presented here is both robust and the resulting stimulating electrodes are nearly purely capacitive. Recording and stimulation tests with chick retinas were used to validate the advantageous properties of the electrodes and demonstrate their suitability for high-efficacy neuronal stimulation applications.Electronic supplementary materialThe online version of this article (doi:10.1007/s10544-013-9804-6) contains supplementary material, which is available to authorized users.

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“…If the latest reported values of the electrodes acceptable for cell-based sensors are ranging in general between a few tens of kΩ to 1 MΩ [34,35], the best achieved impedance value being ∼20 kΩ for the Pt black-coated electrode of similar base area, our HE type electrode has impedance on the order of 20–30 kΩ, which is an excellent value to provide accurate data for the envisaged applications. On the other hand, while the phase is above −70° for the first three types, demonstrating capacitive impedance, it becomes −60° for HE , which might indicate both capacitive coupling and resistive conduction for signal transmission [36]. …”

Section: Resultsmentioning

confidence: 99%

Design, Fabrication and Characterization of a Low-Impedance 3D Electrode Array System for Neuro-Electrophysiology

Kusko

Crǎciunoiu

Amuzescu

et al. 2012

Sensors

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Recent progress in patterned microelectrode manufacturing technology and microfluidics has opened the way to a large variety of cellular and molecular biosensor-based applications. In this extremely diverse and rapidly expanding landscape, silicon-based technologies occupy a special position, given their statute of mature, consolidated, and highly accessible areas of development. Within the present work we report microfabrication procedures and workflows for 3D patterned gold-plated microelectrode arrays (MEA) of different shapes (pyramidal, conical and high aspect ratio), and we provide a detailed characterization of their physical features during all the fabrication steps to have in the end a reliable technology. Moreover, the electrical performances of MEA silicon chips mounted on standardized connector boards via ultrasound wire-bonding have been tested using non-destructive electrochemical methods: linear sweep and cyclic voltammetry, impedance spectroscopy. Further, an experimental recording chamber package suitable for in vitro electrophysiology experiments has been realized using custom-design electronics for electrical stimulus delivery and local field potential recording, included in a complete electrophysiology setup, and the experimental structures have been tested on newborn rat hippocampal slices, yielding similar performance compared to commercially available MEA equipments.

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A cone-shaped 3D carbon nanotube probe for neural recording

Cited by 42 publications

References 41 publications

Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

All-carbon-nanotube flexible multi-electrode array for neuronal recording and stimulation

Design, Fabrication and Characterization of a Low-Impedance 3D Electrode Array System for Neuro-Electrophysiology

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