A conjugated gold nanoparticle-azacyanine off-on-off fluorescence probe for sensitive and selective detection of G-quadruplexes

Bilgen, Ecenaz; Forough, Mehrdad; Çetinkol, Özgül Persil

doi:10.1016/j.talanta.2020.121076

Cited by 11 publications

(3 citation statements)

References 53 publications

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“…Among the synthesized CACs, 2e and 2b are anticipated to be the best potential candidates for the optical detection and imaging platforms based on their high QYs. An analogous platform was recently developed utilizing 2b by our group …”

Section: Resultsmentioning

confidence: 99%

Novel Fluorescent Azacyanine Compounds: Improved Synthesis and Optical Properties

et al. 2020

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Benzothiazoles are known to possess a number of biological activities and therefore are considered to be an important scaffold in the design and synthesis of pharmacophores. In this study, an improved synthesis method for novel fluorescent benzothiazole-based cyclic azacyanine (CAC) dyes bearing different electron-donating/withdrawing groups on their scaffold is presented. The improved method enabled us to increase the synthesis yield for the previously reported CACs. More importantly, it allowed us to synthesize new CAC dyes that were not synthesizable with the previously reported method. The synthesized dyes were characterized by 1 H and 13 C NMR spectroscopy, elemental analysis, and mass spectrometry and their optical (absorption and fluorescence) properties were investigated. All of the synthesized CACs were found to be displaying strong absorption within the range of 387–407 nm. The spectral shifts observed in the absorption and fluorescence measurements suggested that the spectroscopic and optical properties of CACs can be directly modulated by the nature of the electron-donating/withdrawing substituents. The fluorescence quantum yields (QYs) of the unsubstituted (parent CAC) and substituted CACs were also measured and compared. The fluorescence QY of CACs with electron-donating substituents (methoxy or ethoxy) was found to be at least four times higher than that of the parent CAC with no substitutions.

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Section: Resultsmentioning

confidence: 99%

Novel Fluorescent Azacyanine Compounds: Improved Synthesis and Optical Properties

et al. 2020

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“…We believe the present approach of an ''off-on'' fluorescent recognition probe is superior to most of the reported DNA detection platforms. 17,18 The as-developed recognition probe takes advantage of its intrinsic luminescence for selective detection of DNAs and does not require additional fluorescent dyes.…”

Section: Introductionmentioning

confidence: 99%

Cobalt(ii)–curcumin cysteine conjugate as c-MYC promoter G-quadruplex selective switch-on fluorescence probe

Dwivedi¹,

Jha²

2023

New J. Chem.

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“…FRET, a non-radiative energy transfer process, depends on the distance between energy donors and acceptors [18]. Actually, the FRET mechanism has been extensively-used in the screening and detection of various analytes [19][20][21][22][23][24][25]. For example, Deka et al [19] developed a FRET-based method to determine the helicase activity using the optical properties of DNA-conjugated AuNPs.…”

Section: Introductionmentioning

confidence: 99%

Development of gold nanoparticles-aptamer nanocomposite for multiplexed analysis of antibiotics and design of molecular logic gates

Yang¹,

Zhang²,

Zhao³

et al. 2021

Nanotechnology

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The widespread use of antibiotics caused severe problems of antibiotic residues in foodstuffs and water, posing a serious threat to public health and thus urging the development of sensitive, selective, and rapid detection methods for antibiotics. In this study, a fluorescence resonance energy transfer (FRET)-based system is developed for the multiplexed analysis of chloramphenicol (CAP) and streptomycin (Strep) with detection limits of 2.51 and 8.69 μg l−1, respectively. The FRET-based system consists of Cy3-tagged anti-CAP aptamer-conjugated gold nanoparticles (AuNPs) (referred to as AuNPs-AptCAP) and Cy5-tagged anti-Strep aptamer-conjugated AuNPs (referred to as AuNPs-AptStrep). In addition, AuNPs-AptCAP and AuNPs-AptStrep have been demonstrated to serve as signal transducers for implementing a series of logic operations such as YES, NOT, INH, OR, (2-4)-Decoder and even more complicated multi-level logic gates (OR-INH). Based on the outputs of logic operations, it could be figured out whether targeted analytes were present or not, thus enabling multiplex sensing and evaluation of pollution status. This proof of concept study might provide a new route for the enhanced sensing performance to distinguish different pollution status as well as the design of molecular mimics of logic elements to demonstrate better applicability.

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A conjugated gold nanoparticle-azacyanine off-on-off fluorescence probe for sensitive and selective detection of G-quadruplexes

Cited by 11 publications

References 53 publications

Novel Fluorescent Azacyanine Compounds: Improved Synthesis and Optical Properties

Novel Fluorescent Azacyanine Compounds: Improved Synthesis and Optical Properties

Cobalt(ii)–curcumin cysteine conjugate as c-MYC promoter G-quadruplex selective switch-on fluorescence probe

Development of gold nanoparticles-aptamer nanocomposite for multiplexed analysis of antibiotics and design of molecular logic gates

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