A conscious dog model for study of regional lung function

Abstract

Using a specially designed mask and steady-state administration of the short-lived radioactive gas 81mKr, we measured the distribution of the ventilation-perfusion ratio (VA/Q) in the lungs of normal conscious standing greyhound dogs during tidal breathing. This model allows measurement of regional lung function unaffected by anesthesia and mechanical ventilation. An assessment of the distribution of VA/Q in the lungs of normal greyhound dogs revealed that topographically, ventilation and blood flow are well matched in the conscious dog.

Retrospective evaluation of negative‐pressure pulmonary edema in dogs (2006‐2018): 35 cases

“… 8,9,14 A recent radiographic study found that NPPE produces caudodorsal lung patterns more frequently than the other causes of non‐cardiogenic PE 14 . It is unknown why NPPE has this predilection for the caudodorsal area, but it could be that because dogs have increased pulmonary blood volume and flow in the caudal lung lobes 15 they are more likely to have transvascular fluid filtration associated with NPPE in this region. This increase of pulmonary blood flow (PBF) in the dorsocaudal area against gravity is also seen in other standing quadrupeds like horses 16 .…”

Retrospective evaluation of noncardiogenic pulmonary edema in dogs and cats (2000–2021): 31 cases

“…In the current study, the distribution of lesions was described as primarily caudodorsal in 47% of dogs, with a diffuse pattern only slightly more common. The predilection of NCPE for a caudodorsal distribution is not completely understood but is likely associated with increased pulmonary blood volume and flow in the caudal lung lobes of dogs 13 . Dogs also have relatively more negative pleural pressures in the dorsal lung fields as compared to ventral regions, which may be relevant in cases of upper airway obstruction 14 .…”

“…The predilection of NCPE for a caudodorsal distribution is not completely understood but is likely associated with increased pulmonary blood volume and flow in the caudal lung lobes of dogs. 13 Dogs also have relatively more negative pleural pressures in the dorsal lung fields as compared to ventral regions, which may be relevant in cases of upper airway obstruction. 14 Despite the frequency of caudodorsal distribution, diffuse lesions were most common and should not deter a clinician from a diagnosis of NCPE.…”

Quantitative analysis of scintigraphic findings in tibial stress fractures in Thoroughbred racehorses

“…8,9,14 A recent radiographic study found that NPPE produces caudodorsal lung patterns more frequently than the other causes of noncardiogenic PE. 14 It is unknown why NPPE has this predilection for the caudodorsal area, but it could be that because dogs have increased pulmonary blood volume and flow in the caudal lung lobes 15 they are more likely to have transvascular fluid filtration associated with NPPE in this region. This increase of pulmonary blood flow (PBF) in the dorsocaudal area against gravity is also seen in other standing quadrupeds like horses.…”