A consecutive synthesis of spirocyclopentanes from 2,4-dioxo-arylbutanoates, malononitrile and vicinal dicarbonyl compounds

Parhami, Azadeh; Yavari, Issa

doi:10.1080/00397911.2021.1955269

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Cited by 3 publications

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“…Therefore, discovering new ways to control these pathogens is important. In continuation of our attempts to nd new synthetic procedures for spirans [10][11][12], we report on the synthesis of some bis-spiroheterocycles 4 from the reaction of isatin (1), secondary amines 2, and alkylidene Melderum's acids 3 in MeCN at room temperature.…”

Section: Introductionmentioning

confidence: 99%

Formation of bis-spiropyrrolidines from isatin, secondary amins, and alkylidene Meldrum’s acids

Khandan

Yavari

2022

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A synthesis of stable bis-spiropyrrolidines from isatin, secondary amines, and alkylidene Meldrum’s acids in MeCN in 75–95% yield is described. The antioxidant properties and antimicrobial abilities of the synthesized compounds are investigated. For this purpose, the radical scavenging activities of four derivatives were studied by radical trapping of diphenylpicrylhydrazine and ferric reduction power experiments. Disk diffusion test on Gram-positive and Gram-negative bacteria employed to investigate antibacterial activities of five derivatives.

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Section: Introductionmentioning

confidence: 99%