A conserved axon type hierarchy governing peripheral nerve assembly

Wang, Liang; Mongera, Alessandro; Bonanomi, Dario; Cyganek, Lukas; Pfaff, Samuel L.; Nüsslein‐Volhard, Christiane; Marquardt, Till

doi:10.1242/dev.106211

Cited by 24 publications

(22 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fish, birds, and mammals, peripheral nerves are not only composed of afferent sensory axons but also include efferent pathways controlling diverse aspects of peripheral organ function. In this work, we did not focus on the relationship between afferent and efferent axons during peripheral nerve regeneration, as it has been shown that sensory efferent projections rely for growth on their association with pre-formed sensory afferent trajectories [ 79 ]. These authors also showed that this relationship between both types of axons is preserved from fish to mammals.…”

Section: Discussionmentioning

confidence: 99%

Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae

et al. 2014

View full text Add to dashboard Cite

BackgroundPeripheral nerve injuries can severely affect the way that animals perceive signals from the surrounding environment. While damage to peripheral axons generally has a better outcome than injuries to central nervous system axons, it is currently unknown how neurons re-establish their target innervations to recover function after injury, and how accessory cells contribute to this task. Here we use a simple technique to create reproducible and localized injury in the posterior lateral line (pLL) nerve of zebrafish and follow the fate of both neurons and Schwann cells.ResultsUsing pLL single axon labeling by transient transgene expression, as well as transplantation of glial precursor cells in zebrafish larvae, we individualize different components in this system and characterize their cellular behaviors during the regenerative process. Neurectomy is followed by loss of Schwann cell differentiation markers that is reverted after nerve regrowth. We show that reinnervation of lateral line hair cells in neuromasts during pLL nerve regeneration is a highly dynamic process with promiscuous yet non-random target recognition. Furthermore, Schwann cells are required for directional extension and fasciculation of the regenerating nerve. We provide evidence that these cells and regrowing axons are mutually dependant during early stages of nerve regeneration in the pLL. The role of ErbB signaling in this context is also explored.ConclusionThe accessibility of the pLL nerve and the availability of transgenic lines that label this structure and their synaptic targets provides an outstanding in vivo model to study the different events associated with axonal extension, target reinnervation, and the complex cellular interactions between glial cells and injured axons during nerve regeneration.

show abstract

Section: Discussionmentioning

confidence: 99%

Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The motor neural networks were the first to evolve, followed by the sensory and autonomic [84]. All vertebrates have a well-developed motor network.…”

Section: Innervation Of the Skeleton—overviewmentioning

confidence: 99%

Evolution of the Marrow Adipose Tissue Microenvironment

Craft

Scheller

2016

Calcif Tissue Int

View full text Add to dashboard Cite

Adipocytes of the marrow adipose tissue (MAT) are distributed throughout the skeleton, are embedded in extracellular matrix, and are surrounded by cells of the hematopoietic and osteogenic lineages. MAT is a persistent component of the skeletal microenvironment and has the potential to impact local processes including bone accrual and hematopoietic function. In this review, we discuss the initial evolution of MAT in vertebrate lineages while emphasizing comparisons to the development of peripheral adipose, hematopoietic, and skeletal tissues. We then apply these evolutionary clues to define putative functions of MAT. Lastly, we explore the regulation of MAT by two major components of its microenvironment, the extracellular matrix and the nerves embedded within. The extracellular matrix and nerves contribute to both rapid and continuous modification of the MAT niche and may help to explain evolutionary conserved mechanisms underlying the coordinated regulation of blood, bone, and MAT within the skeleton.

show abstract

“…From Wang et al (2014), where further details may be found. Axons forming the dorsal primary ramus (dr) branch off toward the epimere (epaxial muscle) at E10.5.…”

Section: The Formation Of Motor Columnsmentioning

confidence: 99%

Spinal Cord and Peripheral Nervous System

Morriss‐Kay

2016

Kaufman's Atlas of Mouse Development Supplement

View full text Add to dashboard Cite

A conserved axon type hierarchy governing peripheral nerve assembly

Cited by 24 publications

References 49 publications

Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae

Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae

Evolution of the Marrow Adipose Tissue Microenvironment

Spinal Cord and Peripheral Nervous System

Contact Info

Product

Resources

About