2019
DOI: 10.1038/s41467-018-08273-9
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A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing

Abstract: Gene regulatory mechanisms rely on a complex network of RNA processing factors to prevent untimely gene expression. In fission yeast, the highly conserved ortholog of human ERH, called Erh1, interacts with the YTH family RNA binding protein Mmi1 to form the Erh1-Mmi1 complex (EMC) implicated in gametogenic gene silencing. However, the structural basis of EMC assembly and its functions are poorly understood. Here, we present the co-crystal structure of the EMC that consists of Erh1 homodimers interacting with M… Show more

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Cited by 38 publications
(87 citation statements)
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References 64 publications
(106 reference statements)
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“…S2), indicating that Erh1 does not contribute to Mei2 down-regulation in mitotic cells. This is also consistent with the notion that Mmi1 can exert functions independently of Erh1, as in case of transcription termination 20,30 .…”
Section: Formation Of Erh1 Homodimer Is Required For Gametogenic Genesupporting
confidence: 91%
See 4 more Smart Citations
“…S2), indicating that Erh1 does not contribute to Mei2 down-regulation in mitotic cells. This is also consistent with the notion that Mmi1 can exert functions independently of Erh1, as in case of transcription termination 20,30 .…”
Section: Formation Of Erh1 Homodimer Is Required For Gametogenic Genesupporting
confidence: 91%
“…An evolutionary highly conserved region present on the side of the homodimerization surface has been shown to participate in the interaction with Mmi1 (a short region encompassing residues 95-122; 20 ) while this work was in progress ( Fig. 1E).…”
Section: An Evolutionary Conserved Homodimermentioning
confidence: 99%
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