A Consideration of the Hypercalciuria in Sarcoidosis, Idiopathic Hypercalciuria, and That Produced by Vitamin D. A New Suggestion Regarding Calcium Metabolism*

Jackson, W. P. U.; Dancaster, C. P.

doi:10.1210/jcem-19-6-658

Cited by 100 publications

(29 citation statements)

References 24 publications

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“…In only a few patients with idiopathic hypercalciuria zero calcium balances were found (10,14), but in most patients a slightly negative calcium balance was observed (10,12,14,15). Four of our patients were in a slightly negative calcium balance while receiving a diet adjusted to their usual calcium intake.…”

Section: Resultsmentioning

confidence: 53%

“…On (8) were the first to draw attention to the low fecal calcium excretion in patients with idiopathic hypercalciuria. Other investigators confirmed this finding (9,10,12,14,15), which was interpreted as being due to intestinal hyperabsorption. Edwards and Hodgkinson (14) found a mean net intestinal absorption of calcium, i.e., calcium intake minus fecal calcium expressed as a fraction of calcium intake, of 32% in 11 renal stone patients with idiopathic hypercalciuria as compared to 25% in those with a normal daily excretion of calcium, the difference being significant.…”

Section: Resultsmentioning

confidence: 63%

“…Our observations are in accord with these findings. In contrast, in a patient with hypercalciuria due to sarcoidosis, a condition in which intestinal calcium hyperabsorption is well established (15,36,37), the response to a low calcium diet was similar to that of normals (14). It was also observed that patients with idiopathic hypercalciuria excreted during fasting 2-3 times more calcium in their urine than fasting normal controls.…”

Section: Resultsmentioning

confidence: 99%

“…Jackson and Dancaster (15) were the first to suggest that patients with idiopathic hypercalciuria have a primary renal calcium loss, intestinal hyperabsorption being secondary. Patients with idiopathic hypercalciuria have an increased renal calcium clearance, but no evidence of an increased filtered load of calcium has been found (38), indicating that the tubular reabsorption of calcium is reduced.…”

Section: Resultsmentioning

confidence: 99%

“…The name idiopathic hypercalciuria was retained, however, for a syndrome of unknown etiology characterized by an abnormally high renal excretion of calcium, normocalcemia, usually normophosphatemia, with or without renal stones and generally without radiological evidence of bone disease (8,9,12). Metabolic studies revealed that patients with idiopathic hypercalciuria generally have a low fecal calcium excretion indicating hyperabsorption of calcium from the intestine (8)(9)(10)(12)(13)(14)(15) and are in slightly negative or normal calcium balance (10,12,14,15).…”

Section: Introductionmentioning

confidence: 99%

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Metabolic and calcium kinetic studies in idiopathic hypercalciuria

Liberman¹,

Sperling²,

Atsmon³

et al. 1968

J. Clin. Invest.

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A B S T R A C T Calcium balances and calcium kinetic studies using 47Ca were performed in nine male patients with idiopathic hypercalciuria and in three normal male subjects. A sharp reduction in calcium intake in eight patients with idiopathic hypercalciuria caused a decrease in urinary calcium excretion, the latter remaining elevated above that reported for normal subjects on a low calcium diet. The hypercalciuric patients had an enlarged miscible calcium pool size, an increased calcium turnover rate, increased bone formation and bone resorption rates, and an elevated true intestinal calcium absorption rate, the increase of the latter three parameters being proportional to the increase of the turnover rate. The fraction of the calcium turnover rate excreted in the urine was elevated whereas that constituted by the endogenous fecal calcium excretion was decreased. Arguments are presented for the concept that the primary abnormality in idiopathic hypercalciuria is neither renal calcium hyperexcretion nor intestinal calcium hyperreabsorption, but a more fundamental disturbance in calcium metabolism of as yet unknown cause, leading to a high calcium turnover.

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Section: Resultsmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 63%