A Consistent Abnormality in the Average Local Smoothness of Fetal Heart Rate in Growth-Restricted Fetuses Affected by Severe Pre-Eclampsia

Yum, Myung‐Kul; Kim, Kyungsik; Kim, Jong-Hwa; Park, Eun‐Young

doi:10.1291/hypres.27.911

Cited by 8 publications

(6 citation statements)

References 31 publications

(23 reference statements)

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“…Entropy indices were also tested in the antepartum period [37], as well as fractal indices [18], namely regarding the study of intrauterine growth-retarded fetuses [30,42] and the detection of typical FHR patterns [15]. Fractals may be particularly suitable for the analysis of long-term variations of non-stationary signals with poor quality [14], an interesting aspect that deserves further investigation.…”

Section: Discussionmentioning

confidence: 99%

Linear and nonlinear fetal heart rate analysis of normal and acidemic fetuses in the minutes preceding delivery

et al. 2006

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Linear and nonlinear fetal heart rate (FHR) indices, namely mean FHR, interval index (II), very low, low and high frequencies, approximate (ApEn) and sample entropy (SampEn), were computed, immediately before delivery, in the initial and final FHR tracing segments, from 48 normal, 10 mildly acidemic and 10 moderate-to-severely acidemic fetuses. Progression of labor was associated with a significant increase in linear frequency domain indices whereas nonlinear indices were significantly decreased. Moderate-to-severe fetal acidemia was associated with a significant decrease in nonlinear indices. The best discrimination between moderate-to-severe acidemic fetuses and the remaining cases was obtained combining II and ApEn(2,0.15), with a specificity of 71% and a sensitivity of 80%. These findings support the hypothesis of increased autonomic nervous system activity in the final minutes of labor and of decreased central nervous system activity, both in the final minutes of labor and in moderate-to-severe acidemic fetuses.

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Section: Discussionmentioning

confidence: 99%

Linear and nonlinear fetal heart rate analysis of normal and acidemic fetuses in the minutes preceding delivery

et al. 2006

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“…Entropy indices have been tested, with interesting results, in the assessment of FHR tracings, both in laboratory animals (Chaffin et al 1998, Li et al 2004 and human foetuses, not only in the antepartum period (Signorini et al 2003) but also in the intrapartum period (Pincus and Viscarello 1992, Dawes et al 1992, Salamalekis et al 2002. Fractal indices were also used in preliminary studies in the last decade (Gough 1993), namely regarding the study of intra-uterine growth retarded foetuses (Di Renzo et al 1996, Yum et al 2004. Fractal indices were also used by our research group regarding the detection of typical FHR patterns (Felgueiras et al 1998) and may be particularly suitable for the analysis of long-term variations of non-stationary signals with poor quality (Echeverria et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Internal versus external intrapartum foetal heart rate monitoring: the effect on linear and nonlinear parameters

et al. 2006

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The effect of foetal heart rate (FHR) acquisition mode on linear and nonlinear parameters is still largely unknown. In 33 normal labouring women, FHR signals were acquired simultaneously by an external ultrasound sensor applied to the maternal abdomen and an internal scalp electrode, in the minutes preceding delivery. For each case, the initial and final 5, 10 and 20 min segments were analysed, considering FHR signals at a frequency of 4 Hz (the frequency at which they are transmitted by the majority of commercialized foetal monitors). Several time and frequency domain linear and nonlinear FHR indices were computed in these segments, namely mean FHR, very low frequency (VLF), low frequency (LF), high frequency (HF), approximate entropy (ApEn) and sample entropy (SampEn). Parametric confidence intervals, statistical tests and correlation coefficients were calculated in order to evaluate the effect of internal versus external FHR monitoring modes on the considered indices. The whole evaluation was repeated using FHR signals at a frequency of 2 Hz. Most time domain linear indices were similar with external and internal monitoring in the initial and final segments of the tracings. However, linear frequency domain indices were poorly correlated in the final segments and had significantly different mean values in the initial segments. Nonlinear indices were significantly different in both initial and final segments. The correlation between 4 and 2 Hz sampled parameters was high for both linear and nonlinear indices (most correlation coefficient values ranging between 0.95 and 1) but nonlinear index values were significantly higher at 2 Hz. In conclusion, the mode used to acquire FHR signals and the sampling rate employed can significantly affect most FHR indices.

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“…Preeclampsia is associated with maternal and infantile morbidity and mortality (1,2). The early detection of high risk women may be clinically important.…”

Section: Introductionmentioning

confidence: 99%

Establishing Reference Values for Both Total Soluble Fms-Like Tyrosine Kinase 1 and Free Placental Growth Factor in Pregnant Women

et al. 2005

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It has been reported that the concentration of free placental growth factor (PIGF) is decreased and that of soluble fms-like tyrosine kinase 1 (sFlt-1) is increased before the onset of preeclampsia. However, no study has determined the reference values for sFlt-1 and free PIGF during pregnancy using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. This longitudinal cohort study was undertaken to address this issue. Serum samples were collected from 148 women at 10, 18, 28, and 37 weeks of gestation. Preeclampsia occurred in 6 women: 4 women who delivered at <37 weeks of gestation, and 2 women who delivered at > or =37 weeks. The average and 90% confidence interval (90% CI) of the serum concentration of both sFIt-1 and free PIGF were determined in a total of 433 specimens from 148 subjects with 1 to 4 collections at 7 to 39 weeks of gestation, and were represented as quadric curves. The mean values (90% CI) of sFlt-1 (pg/ml) at 10, 18, 28, and 37 weeks of gestation were 413 (174-981), 296 (125-704), 413 (174-982), and 1,130 (477-2,690), respectively. The mean values (90% CI) of free PIGF (pg/ml) were 36 (14-89), 206 (83-515), 518 (207-1,290), and 354 (142-884), respectively. We also established the reference values for the ratio of sFlt-1/PIGF. These values may be useful for predicting the subsequent occurrence of preeclampsia.

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A Consistent Abnormality in the Average Local Smoothness of Fetal Heart Rate in Growth-Restricted Fetuses Affected by Severe Pre-Eclampsia

Cited by 8 publications

References 31 publications

Linear and nonlinear fetal heart rate analysis of normal and acidemic fetuses in the minutes preceding delivery

Linear and nonlinear fetal heart rate analysis of normal and acidemic fetuses in the minutes preceding delivery

Internal versus external intrapartum foetal heart rate monitoring: the effect on linear and nonlinear parameters

Establishing Reference Values for Both Total Soluble Fms-Like Tyrosine Kinase 1 and Free Placental Growth Factor in Pregnant Women

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