A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model

Jie, Zhuye; Zhu, Qian; Zou, Yuanqiang; Wu, Qili; Qin, Min; He, Dalin; Lin, Xiaoqian; Tong, Xin; Zhang, Jiahao; Zhu, Jun; Luo, Wenjing; Xiao, Xiao; Chen, Shiyu; Wu, Yihe; Guo, Gongjie; Zheng, Shufen; Li, Y M; Lai, Wen‐Ter; Yang, Huanming; Wang, Jian; Xiao, Liang; Chen, Jiyan; Zhang, Tao; Kristiansen, Karsten; Jia, Huijue; Zhong, Shilong

doi:10.1016/j.isci.2023.106960

Cited by 8 publications

(2 citation statements)

References 80 publications

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“…The gut microbiota impacts the overall metabolic balance and regulates serum lipid and glucose levels [ 102 ]. In this meta-analysis examining various biochemical parameters related to CVD, patients showed increased levels of FG and TG compared to HCs.…”

Section: Discussionmentioning

confidence: 99%

Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis

Martins,

Silva,

Ferreira

et al. 2024

Biomolecules

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A notable shift in understanding the human microbiome’s influence on cardiovascular disease (CVD) is underway, although the causal association remains elusive. A systematic review and meta-analysis were conducted to synthesise current knowledge on microbial taxonomy and metabolite variations between healthy controls (HCs) and those with CVD. An extensive search encompassing three databases identified 67 relevant studies (2012–2023) covering CVD pathologies from 4707 reports. Metagenomic and metabolomic data, both qualitative and quantitative, were obtained. Analysis revealed substantial variability in microbial alpha and beta diversities. Moreover, specific changes in bacterial populations were shown, including increased Streptococcus and Proteobacteria and decreased Faecalibacterium in patients with CVD compared with HC. Additionally, elevated trimethylamine N-oxide levels were reported in CVD cases. Biochemical parameter analysis indicated increased fasting glucose and triglycerides and decreased total cholesterol and low- and high-density lipoprotein cholesterol levels in diseased individuals. This study revealed a significant relationship between certain bacterial species and CVD. Additionally, it has become clear that there are substantial inconsistencies in the methodologies employed and the reporting standards adhered to in various studies. Undoubtedly, standardising research methodologies and developing extensive guidelines for microbiome studies are crucial for advancing the field.

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Section: Discussionmentioning

confidence: 99%

Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis

Martins,

Silva,

Ferreira

et al. 2024

Biomolecules

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“…Кроме того, нами была выявлена прямая корреляционная связь между представленностью родов Bacteroides, Odoribacter и вида Faecalibacterium prausnitzii у пациентов с КБС. Прямая корреляция между данными представителями КМ при КБС может быть обусловлена сниженной представленностью продуцентов КЦЖК у пациентов с ишемической болезнью сердца, что было подтверждено в нескольких исследованиях [9,10].…”

Section: обсуждение особенности состава км и взаимосвязей между некот...unclassified

Gut microbiota at different stages of cardiovascular disease continuum

Yafarova,

Dementyeva,

Zlobovskaya

et al. 2024

Cardiovasc Ther Prev

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Aim. To study the relationship of gut microbiota (GM) composition with clinical and paraclinical characteristics of patients with coronary artery disease (CAD) and heart failure with reduced ejection fraction (HFrEF).Material and methods. The study included 64 patients (men, 71,9%) with CAD, 33 (men, 87,9%) with HFrEF and 38 (men, 63,2%) with various cardiovascular risk factors (control group). GM composition was assessed using real-time polymerase chain reaction and next- generation sequencing. To identify correlations of GM composition with clinical and paraclinical characteristics, the Spearman rank correlation coefficient (ρ) was calculated. Generalized linear models (QuasiPoisson, overdispersion) with covariates (age, body mass index) were used to compare groups by phylotype.Results. The relative abundance of Bacillota phylotypes is significantly higher in patients with CAD and HFrEF compared to controls (p<0,001). The Bacillota/Bacteroidota dysbiosis ratio was also significantly higher in patients with CAD and HFrEF than in the control group (p<0,001). According to correlation analysis, the relative representation of methanogenic archaea Methanomassiliicoccaceae, Methanomethylophilaceae (ρ=0,49, p<0,0003) directly correlated with ventricular arrhythmias in patients with HFrEF.Conclusion. Patients with CAD and HFrEF differ significantly from the control group in GM composition at the phylotype level. In the study groups, Bacillota/Bacteroidota dysbiosis ratio was also significantly higher than in the control group. The relative abundance of the archaea Methanomassiliicoccaceae and Methanomethylophilaceae is associated with episodes of ventricular tachycardia/ventricular fibrillation.

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Low-dose valine attenuates diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) in mice by enhancing leptin sensitivity and modulating the gut microbiome

Felicianna,

Lo,

Chen

et al. 2024

Molecular Metabolism

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A consortium of three-bacteria isolated from human feces inhibits formation of atherosclerotic deposits and lowers lipid levels in a mouse model

Cited by 8 publications

References 80 publications

Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis

Unravelling the Gut Microbiome Role in Cardiovascular Disease: A Systematic Review and a Meta-Analysis

Gut microbiota at different stages of cardiovascular disease continuum

Low-dose valine attenuates diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) in mice by enhancing leptin sensitivity and modulating the gut microbiome

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