A contact investigation after exposure to a child with disseminated tuberculosis mimicking inflammatory bowel disease

Kim, Dongsub; Lee, Sodam; Kang, Seongwon; Park, Mi-Sun; Yoo, So-Young; Jeon, Tae Yeon; Choi, Joon-Sik; Kim, Bora; Choi, Jong Rim; Cho, Sun Young; Chung, Doo Ryeon; Choe, Yon Ho; Kim, Yae-Jean

doi:10.3345/kjp.2018.07206

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…Studies show the importance of even one single case in detecting the disease and the contact in TB (15,16). In the present study, 7 patients (11%) were diagnosed with TB in active tuberculosis contact screening, and 13 patients (20%) were detected to have LTBI.…”

Section: Resultssupporting

confidence: 43%

Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold Test in Children

Özen¹,

Üçkardeş²,

Uygun³

et al. 2022

Turkish Journal of Pediatric Disease

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Objective: Interferon-γ release tests (IGRAs) and tuberculin skin testing (TST) are important helpful tests for diagnosing tuberculosis (TB) disease in children. It was aimed to compare the sensitivity and compatibility of QuantiFERON-TB Gold In-tube test (QFT) and TST used in children with TB and Latent tuberculosis infection (LTBI).Material and Methods: A total of 118 patients between September 2018 and January 2020 were included in the study prospectively to determine the case characteristics related to the performance of the tests, and to measure the sensitivity of these tests.Results: A total of 118 patients were included in the study; and 13 (11%) patients presented with pneumonia symptoms and 7 (6%) patients were diagnosed with TB in active TB Contact Screening. TB diagnosis was made 20% microbiologically. Mycobacterium tuberculosis culture positivity was found to be 10%. None of the patients had acidresistant bacilli positivity. The male / female rate was 74/44 in our study (p = 0.006). The median age was found to be 14 (1.17-19.2 years) in males, and 12 (0.33 -17.9 years) in females. The mean age of the LTBI Group was higher than the TB Group at significant levels (p <0.05), and was similar to the non-infected group (p>0.05). A total of 53.5% of the patients had a history of meeting someone with tuberculosis, and 97 children were vaccinated with BCG (82.2%). TST and QFT positivities were 19.5% and 22%, respectively. The most common radiological finding that was detected was consolidation areas. While there was moderate compliance between TST and IGRA test in patients with TB diagnosis (kappa =0.50, p=0.025), no compliance was found between tests in LTBI patients. In patients who were diagnosed with TB and LTBI, the sensitivity of TST was found to be 51.1%, and the sensitivity of QFT was found to be 60.4%. Conclusion:TST seems to continue as the most preferred method of diagnosis in rural areas with limited resources and poor laboratory infrastructure due to the costs and technical considerations.

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Section: Resultssupporting

confidence: 43%

Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold Test in Children

Özen¹,

Üçkardeş²,

Uygun³

et al. 2022

Turkish Journal of Pediatric Disease

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“…In one study (n=206), it was reported that latent TB was detected in 37 children (17.96%) (19). In another study (n=327), TB prevalence was shown to be high in kindergarten-age children (20). In a contact study (Index Case=7), it was reported that households had higher TB parameters than schools (21).…”

Section: Discussionmentioning

confidence: 92%

“…In a study (n=8) conducted in a region where TB prevalence is high, AFBS (positive) was found in 87.5% of patients (age=10-14) diagnosed with cavitary lung tuberculosis (20). In order for AFBS parameter to be analyzed well, the sputum must be taken in sufficient quantities, at the right time and correctly (22).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of School-Based Tuberculosis Screening Results After Index Case (Both Intellectual Disability and Cavitary Pulmonary Tuberculosis)

Özen¹,

Uygun²,

Çetin³

et al. 2021

jarhs

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Objective: Tuberculosis is an important public health problem. Tuberculosis prevalence is high in low-income countries. It is contagious, and therefore a risk for people in public living areas. It is contagious, and therefore a risk for people in public areas. Also, people with intellectual disability stay in the same public areas. Therefore, they are also at risk. The aim of our study was to investigate the contact of persons in the same center with an index case. Materials and methods: Contact investigation was conducted in a training and rehabilitation center. Tuberculosis-specific parameters were measured from the patients. Results: All contacts (n=39) were male. Fifteen contacts were offered follow-up without medication. Fifteen contacts were given medication for prophylaxis. Latent tuberculosis was detected in 8 patients. Possible tuberculosis was detected in one patient. Contagion of tuberculosis from the index case to his roommates measured 16.6%. Tuberculosis contagion from the patient with possible tuberculosis to his roommates measured 37.5%. Patients with latent tuberculosis and possible tuberculosis were medicated according to international criteria. Conclusion: People with intellectual disability do not fully define the symptoms of the disease. Therefore, the prognosis may be made when the disease is diagnosed by a health professional. Also, some tests may not be performed because communication is not possible. For this reason, clinicians should be more careful in screening people with intellectual disability for TB. Also, the fight against tuberculosis should be continued without interruption.

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“…No presente estudo, em relação ao parentesco, a maioria dos contatos eram filhos do caso índice, corroborando outros estudos já realizados no Brasil e na África do Sul (Kigozi et al, 2018;Gazetta et al, 2006). Estudos que investigaram contatos que adoeceram por TB revelam que a maioria concentrava-se nos cônjuges e irmãos dos casos índice (Kim et al, 2018;Jia et al, 2014 (Andrade et al, 2017).…”

Section: Elementos De Vulnerabilidade à Tuberculose Nos Contatos De Punclassified

Contatos de indivíduos com tuberculose: análise na perspectiva da vulnerabilidade

Pinto¹

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A Deus por me amparar nos momentos difíceis, me dar força interior para superar as dificuldades, mostrar o caminho nas horas incertas e me suprir em todas as necessidades. Ao meu amado pai, Josenildo Pinto da Silva, pelo apoio incondicional, confiança, pelas orações e por ser a minha companhia durante todo o processo de coleta de dados. À minha amada mãe, Sônia Mércia Lima pela paciência, por aguentar minhas lamentações, pelo apoio, por ser minha companhia e cuidar com tanto amor de Miguel para que eu pudesse me dedicar em alguns momentos aos estudos. Aos meus irmãos, Maryana Lima Pinto e Gabriel Lima Pinto que estiveram sempre torcendo e acreditando em mim, pelo apoio, pela força e pela ajuda nos cuidados ao Miguel. À minha madrasta, Maria do Socorro M. Montenegro, pelo incentivo, confiança, orações constantes, apoio e carinho em todos os momentos. À Talina Carla da Silva, por seu ombro amigo, sua presença sempre constante, companheirismo, incentivo, apoio, parceria e carinho. À Izolda Freire pela estadia em São Paulo, pela acolhida, pela torcida, pelo carinho e por cuidar de Miguel para que eu pudesse assistir às aulas e estudar. À Cibely Freire, por abrir as portas de sua casa e ter nos acolhido tão bem, pelo carinho e torcida. À Giovanna Mariah Orlandi, pela parceria e amizade, pela disponibilidade de sempre e pela torcida. Ao meu amigo Zé Filho por seu carinho, por torcer pela minha vitória, pela força e apoio constantes. Ao meu amigo Márcio André Ferreira de Sousa, pelo incentivo, pelas orações, pela força, torcida e por acreditar em mim e na minha vitória! A Kerginaldo Barros e Zoraide Barros, pelas orações, pelo apoio e torcida. A todos os integrantes do Grupo de Pesquisa Avaliação de Serviços de Saúde, pela torcida e apoio, em especial os alunos que contribuíram com a coleta de dados: Valdízia, Pedro e Aline e aos queridos Aguinaldo e Rose, pelo apoio nas horas difíceis. Às professoras Dra. Lúcia Izumi e Dra. Paula Hino pelas contribuições no Exame de Qualificação. Aos membros da Comissão Julgadora pela disponibilidade e pelas contribuições que foram sugeridas. A Coordenação da Vigilância Epidemiológica e do Programa de Controle da Tuberculose do município de Campina Grande-PB, pelo fornecimento do banco de dados utilizados neste trabalho. A todos os professores do Programa de Pós-Graduação em Enfermagem da USP que repartiram seus conhecimentos e experiências, contribuindo assim, para minha formação acadêmica. Aos colegas de trabalho do Hospital das Clínicas da UFPE pelo carinho, torcida e apoio, em especial: Rândson Soares, Francimar Nipo, Catarina Vasconcelos, Lilíada Gomes e Míriam Marinho. Aos colegas de trabalho do Hospital Universitário Lauro Wanderley da UFPB pelo carinho, torcida, incentivo e por acreditarem em mim, em especial Carla Mattos, Ana Paula Dantas, Nadja Karla e Rafaela Félix. Enfim, a todos os citados, agradeço por acreditarem no meu potencial, na minha profissão, nas minhas ideias, nos meus devaneios, principalmente quando nem eu mais acreditava. Sem vocês nada disso seria possível. ...

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A contact investigation after exposure to a child with disseminated tuberculosis mimicking inflammatory bowel disease

Cited by 3 publications

References 12 publications

Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold Test in Children

Comparison of Tuberculin Skin Test and QuantiFERON-TB Gold Test in Children

Evaluation of School-Based Tuberculosis Screening Results After Index Case (Both Intellectual Disability and Cavitary Pulmonary Tuberculosis)

Contatos de indivíduos com tuberculose: análise na perspectiva da vulnerabilidade

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