In the last years, hospitals in Brazil have made significant investments in adopting and implementing new hospital information system (HIS). Whether these investments will prove beneficial for these organizations depends on the support that will be provided to ensure the effective use of the information systems (IS) implemented and also on the satisfaction of its users.The purpose of this study is to propose a conceptual model, appropriate for the intention to use HIS, by adopting the system, service, and information qualities covered in the Information System Success Model proposed by DeLone and Mclean.In the present study, structural analysis applied to data from a sample of 393 HIS users showed the variables service quality, information quality, system quality and satisfaction to act as antecedents of HIS success. A novel finding of the study was the importance of the user's aptitude with respect to computer moderating the relationships of the model.Managerial implications are provided accordingly. Suggestions for introducing healthcare information system are then provided as well.